Smooth muscle in the hepatic artery, portal vein and hepatic vein within the liver of the raccoon and guinea pig

The amount and arrangement of smooth muscle in the intrahepatic vessels suggests that the guinea pig would be a good animal model for studying mechanisms controlling intrahepatic portal vein blood flow, while the raccoon would be good for studying hepatic vein mechanisms of control.     

Smooth muscle in the hepatic artery,portal vein and hepatic vein within the liver of the raccoon and guinea pig

Summary The amount and arrangement of smooth muscle in the intrahepatic vessels suggests that the guinea pig would be a good animal model for studying mechanisms controlling intrahepatic portal vein blood flow, while the raccoon would be good for studying hepatic vein mechanisms of control.     

The effect of urethane and pentobarbital anaesthesia and hepatic portal vein catheterization on liver blood flow in the rat

Summary The effect of urethane and pentobarbital anaesthesia and hepatic portal vein catheterization on liver blood flow was investigated in the rat. Liver blood flow with pentobarbital anaesthesia was 40% greater than with urethane. Hepatic portal vein catheterization had no effect under pentobarbital anaesthesia whereas it produced an 18% fall in liver blood flow with urethane.Acknowledgments. This work was supported by grants from ICI Pharmaceuticals and Mersey Regional Health Authority (Research Scheme No. 338). We wish to thank Mr P.J. Roberts for much skilled assistance and Evans Medical Ltd for the kind gift of drugs.     

Metabolic restoration in rat liver after partial hepatectomy

Zusammenfassung Es zeigt sich während des frühen Regenerationsstadiums bei der teilweise hepatektomierten Rattenleber, dass ein Anstieg im Galaktose-Metabolismus mit gleichzeitiger Abnahme seiner Hemmung durch Ethanol einhergeht. Nach vollständiger Geweberegeneration kehrt der normale Metabolismus zurück.

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I wish to thank ProfessorJ. H. Quastel for providing me with the facilities and for his encouragement during my work at McGill University, Montreal (Canada).     

A simple method of obtaining multiple blood samples from the portal vein and the hepatic vein in the rat in vivo

A very simple and rapid technique for inserting a catheter in the portal vein and the hepatic vein in the anesthesized rat in vivo is described. The pointed, saline-containing PE tubing is frozen in liquid nitrogen, whereupon it is used as a 'needle' to insert the catheter into the blood vessel. Multiple blood samples can be obtained from the portal and the hepatic vein at the same time, so that in situ extraction of drugs by the liver can be measured in vivo, since hepatic blood flow is uninterrupted.     

Ethyl-α-p-chlorophenoxyisobutyrate induced hepatic microbody proliferation in rat liver and ubiquinone concentration

Zusammenfassung Verabreichung von körperfremdem Ubiquinon an Ratten verursacht keine vermehrte Aktivität der Leberkatalase, die mit derjenigen nach CPIB-Medikation vergleichbar wäre. Es wird angenommen, dass die hypocholemische Aktion von CPIB nicht von einer Steigerung der hepatischen Ubiquinon-Konzentration begleitet ist.     

Soluble hepatic lectin in regenerating liver

Summary Similar activity of a soluble hepatic lectin was measured in regenerating rat liver 12 h following partial, hepatectomy or gentle manipulation. Lectin response seems to be related to trauma rather than cell proliferation.     

Hepatic proline after bile duct ligation in rats

Since biliary hyperplasia of fascioliasis correlated with hepatic proline level, we examined the occurrence of a similar chemical stimulus during bile obstruction. Uptake of tritiated proline and glycine rose in both hepatocytes and a bile duct enriched cell fraction, following duct ligation in rats. The increased hepatic content of proline but not glycine suggests that proline has a role in post-obstructive biliary proliferation.     

Changes in microsomal lipids of rat liver after chronic carbon tetrachloride intoxication

Riassunto Un prolungato trattamento con tetracloruro di carbonio, tale da indurre una grave cirrosi epatica, determina una diminuzione degli acidi grassi più insaturi (acido arachidonico ed acido docosaexenoico) dei fosfolipidi dei microsomi di fegato di ratto. L'ipotesi che tale diminuzione sia dovuta ad una parziale distruzione di questi acidi grassi attraverso un processo di perossidazione lipidica indotto dal CCl₄, è avvalorata dalla presenza, nei lipidi microsomiali, di una banda di assorbimento caratteristica dei «dieni coniugati».     

Cholinergic nerves in the rat portal vein

Summary The innervation of the rat portal vein was studied using the cholinesterase histochemical method 2 plexuses of cholinergic nerve fibers were found; an external plexus localized at the level of the outer adventitial layers and an inner plexus at the level of the adventitial-medial transitional zone and in the outer layers of the media.Acknowledgments. We thank Dr C. Cavallotti for his kind help and criticism. The kind help of Dr W. Collier and of the staff of the laboratory of Neurobiology as well as the bibliographic assistance of Istituto Superiore di Sanità (Serv. Documentazione, Dr Magliola) are gratefully acknowledged.     

Ultrastructural changes in rat liver cells after intramuscular implantation of a Walker tumor

Résumé L'implantation i.m. de la tumeur de Walker chez les rats provoque une dilatation, une désorganisation et une dégranulation progressives du réticulum endoplasmique granuleux des hépatocytes. Ces changements, qui s'accompagnent en même temps d'une prolifération du réticulum endoplasmique lisse, représenteraient les manifestations ultrastructurales d'une insuffisance microsomale démontrée biochimiquement dans le foie des rats affectés par la tumeur de Walker.

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This work was supported in part by the Ministère des Affaires Sociales, Québec, the Medical Research Council of Canada (Block Term Grant No. MT-1829), the Cancer Research Society Inc., and was undertaken as a special project of the Council for Tobacco Research, USA, and the Canadian Tobacco Industry.     

Acquisition of an embryonal biochemical feature in the rat liver after portacaval shunt

Zusammenfassung In Leberhomogenaten von Ratten mit einem portocavalen «Shunt» wurde gegenüber unbehandelten Kontrolltieren eine zehnfache Vermehrung der Aktivität der -Glutamyltranspeptidase festgestellt. Dieser Befund könnte als Derepression dieses Enzyms gedeutet werden, da ähnlich gesteigerte Enzymaktivitäten bisher nur bei embryonalen Lebern und bei chemisch induzierten Hepatomen gemessen worden sind.