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1.
L. Å. Hanson 《Cellular and molecular life sciences : CMLS》1959,15(12):473-474
Zusammenfassung Mit Hilfe von Immunoelektrophorese und Doppeldiffusiontechnik wurden in Humanmilch an Blutplasmaproteinen serologisch identifiziert: Praealbumin, Albumin, Acid Seromucoid,
1-Glykoprotein (3·5 S), Coeruloplasmin, Haptoglobin,
2- oder-Lipoprotein, Transferrin, Fibrinogen,
2A-Globulin,
2M-Globulin und-Globulin. 相似文献
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Conclusions The decrease of circulating blood volume, resulting in oligemic hypotension, may evoke in anaesthetized cat the active constrictory coronary vessel responses of 2 types, one occuring immediately after start of the hypotension and the other having a significantly prolonged latency.
, , , , ( 4 ), ( 45 ).相似文献
4.
Summary The conversion of cholesterol into 19-nor-5-cholestan-3-ol by the spongeAxinella polypoides involves a partial loss (40%) of the 3-hydrogen atom; moreover administration to the sponge of [4-14C]cholesterol tritiated at C-4 and C-7 showed that the 4- and 7-hydrogen atoms are retained in this conversion. A competitive uptake experiment, [4-14C]cholesterol vs. [7-3H2]5-cholestanol, showed that the sponge utilized exclusively cholesterol for the production of 19-nor-5-cholestan-3-ol.Part of this work has been presented at the Nato Conference on Marine Natural Products (Jersey, Great Britain, October, 1976).-This contribution is part of the Programma finalizzato Oceanografia e Fondi marini-sottoprogetto Risorse biologiche C.N.R. Italy. 相似文献
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A. Furlenmeier A. Fürst A. Langemann G. Waldvogel P. Hocks U. Kerb R. Wiechert 《Cellular and molecular life sciences : CMLS》1966,22(9):573-573
Zusammenfassung Ecdyson, ein Häutungshormon der Insekten, wurde ausgehend von Ergosterin in 14 Stufen synthetisiert. Wesentliche Zwischenprodukte waren (20S)-2, 3-Diacetoxy-20-formyl-5-pregn-7-en-6-on und (22R)-2, 3-Diacetoxy-14, 22-dihydroxy-25-(tetrahydropyran-2-yloxy)-5-cholest-7-en-6-on. 相似文献
6.
I. A. Oyvin L. I. Uklonskaya P. J. Gaponiuk 《Cellular and molecular life sciences : CMLS》1967,23(7):555-556
, - Sr90 + Y90, , . - () . , , - . 相似文献
7.
Antitumor effect of β-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death 总被引:3,自引:0,他引:3
Wang G Li X Huang F Zhao J Ding H Cunningham C Coad JE Flynn DC Reed E Li QQ 《Cellular and molecular life sciences : CMLS》2005,62(7-8):881-893
-Elemene is a novel anticancer drug, which was extracted from the ginger plant. However, the mechanism of action of -elemene in non-small-cell lung cancer (NSCLC) remains unknown. Here we show that -elemene had differential inhibitory effects on cell growth between NSCLC cell lines and lung fibroblast and bronchial epithelial cell lines. In addition, -elemene was found to arrest NSCLC cells at G2-M phase, the arrest being accompanied by decreases in the levels of cyclin B1 and phospho-Cdc2 (Thr-161) and increases in the levels of p27kip1 and phospho-Cdc2 (Tyr-15). Moreover, -elemene reduced the expression of Cdc25C, which dephosphorylates/activates Cdc2, but enhanced the expression of the checkpoint kinase, Chk2, which phosphorylates/ inactivates Cdc25C. These findings suggest that the effect of -elemene on G2-M arrest in NSCLC cells is mediated partly by a Chk2-dependent mechanism. We also demonstrate that -elemene triggered apoptosis in NSCLC cells. Our results clearly show that -elemene induced caspase-3, –7 and –9 activities, decreased Bcl-2 expression, caused cytochrome c release and increased the levels of cleaved caspase-9 and poly(ADP-ribose) polymerase in NSCLC cells. These data indicate that the effect of -elemene on lung cancer cell death may be through a mitochondrial release of the cytochrome c-mediated apoptotic pathway.Received 12 January 2005; accepted 5 February 2005 相似文献
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Summary 6-Methoxy-9,10 -pregna-4,6-diene-3,20-dione inhibites the
4-3-oxosteroid-5-reduction in microsomes and the
4-3-oxosteroid-5-reduction in the soluble fraction of male rat liver. The 3- and 3-hydroxysteroid dehydrogenase are not inhibited by this substance.
Diese Arbeit wurde von der Firma Hoffmann-La Roche, Basel, unterstützt. 相似文献
Diese Arbeit wurde von der Firma Hoffmann-La Roche, Basel, unterstützt. 相似文献
10.
G. N. Telesnina M. A. Novikova G. L. Zhdanov M. N. Kolosov M. M. Shemyakin 《Cellular and molecular life sciences : CMLS》1967,23(6):427-428
a aaa a aa aa a a E. coli aa, a aa aa a , a a aa - a .
Laboratory of Biological Investigations.
Laboratory for Chemistry of Antibiotics. 相似文献
Laboratory of Biological Investigations.
Laboratory for Chemistry of Antibiotics. 相似文献
11.
J. S. Baran H. D. Lennon S. E. Mares E. F. Nutting 《Cellular and molecular life sciences : CMLS》1970,26(7):762-763
Zusammenfassung Die Synthese von 3, 17-Diacetoxy-17-Äthinyl-11-Methylestr-4-en (XII) wird beschrieben. Die Substanz besitzt besonders starke Antifertilitätseigenschaften, wie sie sonst nur Mischungen von Hormonen eigen sind, welche für die Humanfertilität benutzt werden, jedoch ohne deren Nebenwirkungen. 相似文献
12.
, - : - No 199. , ( 3- ) , . 相似文献
13.
Pujol E Rodríguez-Cuenca S Frontera M Justo R Lladó I Kraemer FB Gianotti M Roca P 《Cellular and molecular life sciences : CMLS》2003,60(9):1982-1989
Gender- and site-related differences in the lipolytic capacity, at the different steps of the adrenergic pathway, in gonadal and inguinal white adipose tissue (WAT), were assessed by studying 2A-adrenergic receptor (AR), 3-AR and hormone-sensitive lipase (HSL) protein levels, and by determining the lipolytic response to different agents. Gonadal WAT showed a lower 2A/3-AR ratio, a greater lipolytic capacity in response to AR agonists, and higher HSL activity and protein levels than inguinal WAT. In female rats, we found greater 2A-AR protein levels and 2A/3-AR ratio compared to their male counterparts, but, on the other hand, a higher lipolytic response to -AR agonists and a greater lipolytic capacity at the postreceptor level, including a more activated HSL protein. Thus, the lipolytic capacity was clearly higher in gonadal than in inguinal WAT, at the different steps of the adrenergic pathway studied. Moreover, in both tissues, females showed a greater inhibition of lipolysis via 2-AR, which was counteracted by the higher lipolytic capacity at the postreceptor level.Received 1 April 2003; received after revision 11 June 2003; accepted 23 June 2003 相似文献
14.
. -2, , . 14- in vitro ( ) , in vivo, . . 相似文献
15.
Summary The increasing environmental and occupational exposure of populations to cadmium creates the need for biological indicators of cadmium exposure and toxicity. The advantages and disadvantages of monitoring blood cadmium, urinary, fecal, hair, and tissue cadmium, serum creatinine, 2-microglobulin, 1-antitrypsin and other proteins, and urinary amino acids, enzymes, total proteins, glucose 2-microglobulin, retinol-binding protein, lysozyme, and metallothionein are discussed. It is concluded that urinary cadmium, metallothionein and 2-microglobulin may be used together to assess cadmium, exposure and toxicity. 相似文献
16.
V. M. Zhdanov V. I. Gavrilov S. M. Klimenko N. N. Bogomolova O. G. Andzhaparidze 《Cellular and molecular life sciences : CMLS》1973,29(2):235-236
, . , (180S, 1.42 140S, 133 /) . 相似文献
17.
O. E. Tsitsiloni P. P. Yialouris H. Echner W. Voelter A. A. Haritos 《Cellular and molecular life sciences : CMLS》1992,48(4):398-402
A new radioimmunoassay has been developed for thymosin 4 by generating rabbit polyclonal antibodies against the synthetic N-terminal peptide fragment 1–15 coupled to KLH. The synthetic analogue [Tyr12]-thymosin 4 (1–15) was used as tracer. This radioimmunoassay, with a useful range of 10–1000 pmoles, showed cross-reactivity with the second homologous -thymosin of man and rat (thymosin 10) but not of calf (thymosin 9). This radioimmunoassay, together with an improved radioimmunoassay for the N-terminus of parathymosin , was employed for the measurement of the levels of thymosin 4 and parathymosin in nuclear and extranuclear extracts of calf thymus. The bulk of these polypeptides was found in the extranuclear material whereas only traces were observed in the nuclear environment, which indicates the extranuclear localisation of - and -thymosins. 相似文献
18.
S. Bernasconi M. Ferrari P. Gariboldi M. Sisti G. Bolchi Serini M. Colombo 《Cellular and molecular life sciences : CMLS》1980,36(12):1337-1339
Summary Some compounds containing piperidine rings have been synthesized, and submitted to biological tests on insects for their hormonal activity on pupae ofTenebrio molitor L. andBombyx mori L. Some of them display a hormoneanalogue or toxic activity.The editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. — Les auteurs sont seuls responsables des opinions exprimées dans ces brèves communications. — Für die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich. — Per le brevi comunicazioni è responsabile solo l'autore. — . — Solo los autores son responsables de las opiniones expresadas en estas comunicationes breves.This research has been supported by the Italian National Research Council (CNR) special ad hoc program Fitofarmaci e Fitoregolatori, Subproject. 7.Acknowledgments. We thank Prof. G. Jommi for helpful discussions related to this and previous articles on the same subject. 相似文献
19.
S. E. Akopov M. R. Grigorian E. S. Gabrielian 《Cellular and molecular life sciences : CMLS》1992,48(1):34-36
Neutrophils, activated by 4-phorbol-12-myristate-13-acetate, decreased acetylcholine-induced relaxation of strips of human middle cerebral artery precontracted with noradrenaline. This effect was prevented by catalase, but not by superoxide dismutase. Nifedipine, propranolol and, less markedly, captopril reduced the decrease in acetylcholine-induced relaxation. Aspirin and dipyridamole did not reduce it. 相似文献
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. . 相似文献