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1.
The effect ofγ-irradiation on soil enzyme stability 总被引:1,自引:0,他引:1
R. G. Burns Lindsay J. Gregory G. Lethbridge N. M. Pettit 《Cellular and molecular life sciences : CMLS》1978,34(3):301-302
Summary Arylsulphatase, -1,3 glucanase, phosphatase and urease responded differently to -irradiation (5–50 Mrad) in air-dried and moist soils. In all instances phosphatase was the most stable. The variability between enzymes may be due to inherent biochemical and stuctural characteristics or to their location within the soil microenvironment.Supported by a grant from the NERC. 相似文献
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Zusammenfassung Das hämopoietische Gewebe des Femurs junger Albinoratten wurde in einer Lösung, die 5% Na-Zitrat (1 Teil) und 0,7% Na-Chlorid (4 Teile) enthielt, suspendiert. Die Megakaryozyten, deren Durchmesser 24 µ überschritt, wurden in einer Bürker-Kammer gezählt. Der Effekt der Ganzkörperbestrahlung auf das Megakaryozytensystem wurde untersucht durch Festlegung des femoralen Megakaryozytengehaltes während den ersten 7 Tagen nach der Bestrahlung. 相似文献
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Résumé L'acide-amino-butyrique et la-alanine reproduisent l'action du transmetteur inhibiteur du système neuromusculaire de l'écrevisse. Ces deux acids aminés diminuent la contraction musculaire. L'acide-amino-butyrique réduit la différence de potentiel et augmente sa décomposition. L'action de ces acides aminés est bloquée par la picrotoxine comme l'est celle du transmetteur inhibiteur.
The study was supported by Grants B-1089 and B-31 from the National Institute of Neurological Diseases and Blindness, United States Public Health Service. Some of this work was done at the Department of Zoology, Cornell University. We are grateful to Prof.S. C. Wang, Columbia University, for generous assistance. 相似文献
The study was supported by Grants B-1089 and B-31 from the National Institute of Neurological Diseases and Blindness, United States Public Health Service. Some of this work was done at the Department of Zoology, Cornell University. We are grateful to Prof.S. C. Wang, Columbia University, for generous assistance. 相似文献
5.
Doerwald L van Genesen ST Onnekink C Marín-Vinader L de Lange F de Jong WW Lubsen NH 《Cellular and molecular life sciences : CMLS》2006,63(6):735-743
The mechanism of the translational thermotolerance provided by the small heat shock proteins (sHsps) αB-crystallin or Hsp27
is unknown. We show here that Hsp27, but not αB-crystallin, increased the pool of mobile stress granule-associated enhanced
green fluorescent protein (EGFP)-eukaryotic translation initiation factor (eIF)4E in heat-shocked cells, as determined by
fluorescence recovery after photobleaching. Hsp27 also partially prevented the sharp decrease in the pool of mobile cytoplasmic
EGFP-eIF4G. sHsps did not prevent the phosphorylation of eIF2α by a heat shock, but promoted dephosphorylation during recovery.
Expression of the C-terminal fragment of GADD34, which causes constitutive dephosphorylation of eIF2α, fully compensated for
the stimulatory effect of αB-crystallin on protein synthesis in heat-shocked cells, but only partially for that of Hsp27.
Our data show that sHsps do not prevent the inhibition of protein synthesis upon heat shock, but restore translation more
rapidly by promoting the dephosphorylation of eIF2α and, in the case of Hsp27, the availability of eIF4E and eIF4G.
Received 9 December 2005; received after revision 16 January 2006; accepted 23 January 2006 相似文献
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P. J. Chan 《Cellular and molecular life sciences : CMLS》1987,43(8):929-930
Summary The in vitro development and attachment of hatched mouse blastocysts on the untreated substratum was enhanced by 10 M dibutyryl cCMP (dbcCMP). The result suggests that cCMP has an effect on embryonic development and on the blastocyst attachment process.25 November1986 相似文献
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Summary Unconjugated and conjugated bile salts inhibited the conversion of thyroxine to 3,3,5 triiodothyronine in rat liver homogenate.This work was supported in part by a grant from the Imanaga Foundation, Nagoya, Japan. 相似文献
9.
R. Thun P. Wild F. Mettler M. Djafarian 《Cellular and molecular life sciences : CMLS》1982,38(12):1494-1496
Summary The effect of o,p-DDD (200 mg/kg/day given p.o. for 100 consecutive days) on the sheep adrenal gland was studied. The results suggest that this ruminant species is highly resistant to the adrenocorticolytic activity of o,p-DDD when compared with dogs.This work was supported by a grant of Bristol Laboratories, Syracuse, New York 13201, USA. 相似文献
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Summary Chronic marginal vitamin C deficiency lasting 270 days induced hypertriglyceridaemia, an abrupt fall of ascorbic acid in all organs and a significant decrease of -tocopherol in the liver and the lungs in guinea-pigs. 相似文献
11.
P. Drochmans 《Cellular and molecular life sciences : CMLS》1947,3(10):421-423
Résumé Chez la souris, 24 heures après la ligature du pédicule d'un lobe hépatique, la basophilie cytoplasmique disparaît alors que les noyaux conservent une colorabilité normale par la méthode deFeulgen. Les dosages chimiques établissent que le taux de l'acide ribonucléique s'abaisse considérablement, tandis que celui de l'acide désoxyribonucléique ne subit pas de modifications appréciables. Ces phénomènes sont liés à la destruction des granules et microsomes séparables par ultracentrifugation. Une partie de ces nucléoprotéines se retrouve, après ultracentrifugations répétées, dans le liquide surnageant. 相似文献
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Riassunto Il 5HTP, direttamente iniettato nel circolo cerebrale, produce un quadro elettroencefalografico di sonno, indipendente da modificazioni di flusso nel circolo cerebrale e da eventuali metaboliti che si formano al di fuori del cervello. La 5HT, iniettata nelle stesse condizioni, o è senza effetto o dà una reazione elettroencefalografica di risveglio. 相似文献
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N. K. McCallum A. Gugelmann C. A. M. Brenninkmeijer R. Mechoulam 《Cellular and molecular life sciences : CMLS》1977,33(8):1012-1014
Summary Isotope effect studies on the metabolic dehydrogenation of 1-tetrahydrocannabinol in rats are described and its is shown that this process is confined to a very short period following i.v. administration. The implications of this finding are discussed.The authors are grateful for generous fifts of3H-1-THC from Dr S. Burstein (Worcester Foundation for Experimental Biology, Massachusetts), and of14C-1-THC from the National Institute on Drug Abuse. The authors thank the staff of the Small Animal Unit, Wallaceville Research Centre for their cooperation, and the U.S. National Institute on Drug Abuse for their support. 相似文献
15.
The in vivo expression of the globin genes of theβ cistron in γ-,δ-, andδβ-thalassemia heterozygotes
A. J. Dimovski A. D. Adekile T. H. J. Huisman 《Cellular and molecular life sciences : CMLS》1994,50(2):167-170
There is considerable evidence suggesting that the switch from to and chain production after birth is due, in part, to silencing of the genes by stage-specific factors which bind to their promoters and to the competition from the adult ( and ) genes for a common enhancer element located in the locus control region. As a consequence one can expect that the increased Hb F production in adults with hereditary persistence of fetal hemoglobin or -thalassemia is directed mainly by -globin genes in cis to the deletion(s) responsible for these conditions. Here we review data on heterozygotes with -, -, or -thalassemia, who also had anAT mutation, in cis or in trans, which was used as a marker of gene expression. The results show that a deletion affecting adult genes favors the expression of genes in cis, while the deletion of a single gene does not affect the expression of the gene in cis but leads to a faster switch postnatally. 相似文献
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Summary When injected into 12-day-old suckling rats, dexamethasone caused a precocious disappearance of Fc receptors from enterocytes of the proximal small intestine. However, dexamethasone appeared to be necessary for the maintenance or production of such receptors in foetal rat gut cultured in vitro.Supported by an award from the Science and Engineering Research Council. 相似文献
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J. T. A. Leuschner D. R. Wing Dr. D. J. Harvey G. A. Brent C. E. Dempsey A. Watts W. D. M. Paton 《Cellular and molecular life sciences : CMLS》1984,40(8):866-868
Summary
1-Tetrahydrocannabinol (
1-THC) has been quantified directly in erythrocyte membranes from drug-treated mice using gas chromatography/mass spectrometry. Concentrations of approximately 6 ng
1-THC/mg membrane protein (10–5 M) were found when effects of the drug on behavior were prevalent. At these concentrations the drug produced a decrease in membrane order as measured by ESR.This work was supported by grants from the Medical Research Council, the Wellcome Trust and the E. P. Abraham Cephalosporin Trust 相似文献
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D. V. Amin R. B. Doctor A. O. Girdhar U. H. Shah 《Cellular and molecular life sciences : CMLS》1980,36(12):1410-1411
Summary Prostaglandin (PG) release was measured from the isolated perfused rabbit heart. The effects of -adrenergic stimulation and blockade suggest that PG synthesis is regulated in part by adrenergic mechanisms. 相似文献
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Noel A. Warren Georgios Voloudakis Yonejung Yoon Nikolaos K. Robakis Anastasios Georgakopoulos 《Cellular and molecular life sciences : CMLS》2018,75(15):2813-2826
Presenilin-1 (PS1) gene encodes the catalytic component of γ-secretase, which proteolytically processes several type I transmembrane proteins. We here present evidence that the cytosolic peptide efnB2/CTF2 produced by the PS1/γ-secretase cleavage of efnB2 ligand promotes EphB4 receptor-dependent angiogenesis in vitro. EfnB2/CTF2 increases endothelial cell sprouting and tube formation, stimulates the formation of angiogenic complexes that include VE-cadherin, Raf-1 and Rok-α, and increases MLC2 phosphorylation. These functions are mediated by the PDZ-binding domain of efnB2. Acute downregulation of PS1 or inhibition of γ-secretase inhibits the angiogenic functions of EphB4 while absence of PS1 decreases the VE-cadherin angiogenic complexes of mouse brain. Our data reveal a mechanism by which PS1/γ-secretase regulates efnB2/EphB4 mediated angiogenesis. 相似文献
20.
Therian mammals (marsupials and placentals) have an XX female: XY male sex chromosome system, which is homologous to autosomes
in other vertebrates. The testis-determining gene, SRY, is conserved on the Y throughout therians, but is absent in other vertebrates, suggesting that the mammal system evolved
about 310 million years ago (MYA). However, recent work on the basal monotreme mammals has completely changed our conception
of how and when this change occurred. Platypus and echidna lack SRY, and the therian X and Y are represented by autosomes, implying that SRY evolved in therians after their divergence from monotremes only 166 MYA. Clues to the ancestral mechanism usurped by SRY in therians are provided by the monotremes, whose sex chromosomes are homologous to the ZW of birds. This suggests that the
therian X and Y, and the SRY gene, evolved from an ancient bird-like sex chromosome system which predates the divergence of mammals and reptiles 310 MYA.
Received 4 March 2008; received after revision 22 April 2008; accepted 3 June 2008 相似文献