Granuloma formation in rat liver after hepatic vein ligation

Summary After occlusion of the hepatic vein draining 1 lobe of the rat liver, macrophage granulomas develop which are reproducible and apparently related to a heat-labile macrophage mobilising factor.     

Effect of hypothalamic lesions on MSH content of the intermediate lobe of the pituitary gland in the rat

Zusammenfassung Es wird gezeigt, dass Elektrokoagulation in verschiedenen Teilen des basalen Hypothalamus einen Einfluss auf den Melanophorenhormongehalt im Hypophysenzwischenlappen der Ratte hat.     

Effect of amygdaloid lesions on plasma corticosterone response of the albino rat to emotional stress

Zusammenfassung Im Vergleich zu Kontrolltieren mit zweiseitigen Rindenläsionen führt beidseitige Zerstörung des Nucleus centralis im Mandelkernkomplex der Ratte zu erhöhter Plasma-Corticosteron-Produktion nach kurzfristigem Stress durch entsprechende Immobilisierung.

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This study was made possible by a special research fellowship to one of us,E. W. Bovard, from the United States Public Health Service, sponsored by the National Institute of Mental Health. The writers would like to acknowledge with thanks the interest and friendly cooperation of Dr.H. Jasper, Dr.Hanna Pappius, Dr.Marion K. Birmingham, and the medical and technical staff of Montreal Neurological Institute in this work. This paper was originally presented at a meeting of the Montreal Physiological Society, March 8, 1961.     

Effect of angiotensin II on neonatal lamb carotid arteries.

Isometric tension was measured in arterial strips from neonatal lambs and adult sheep, after stimulation by angiotensin II. During the early maturation period immediately following birth (3 weeks) there was a progressive increase in sensitivity to the agent.     

Effect of clofibrate on the phospholipid biosynthesis in rat liver.

The effect of clofibrate on rat liver phospholipid biosynthesis was studied using 32P as a precursor. Phospholipid classes, levels and specific radioactivity were evaluated. Significant increases in levels of phosphatidylethanolamine and phosphatidylcholine were found and could account for the observed increase in total phospholipids. Specific activity of phosphatidylserine increased and that of phosphatidylethanolamine decreased. This fact suggests that clofibrate seems to alter the systems engaged in the transformation occurring within the different classes of phospholipids but not the de novo biosynthesis.     

Effect of pancreatic duct ligation on exocrine pancreatic function and structure in the rabbit

Summary 4 weeks after pancreatic duct ligation in the rabbit, fecal and luminal chymotrypsin were detected in concentrations similar to the control group. Pancreatic changes in the ligated group were marked dilatation of the main pancreatic duct, proliferation and distention of ductules and fibrosis. Despite pancreatic duct ligation and fibrosis, proteolytic enzymes continued to secrete into the duodenal lumen. These results suggest that pancreatic duct ligation in the rabbit is not associated with total pancreatic insufficiency.This study was supported by the Kansas University Endowment Association (Grant No. 73-2550), General Research Support (Grant No. 2553 and 1522-14) and a grant from Kaw Valley Heart Association.     

Effect of pancreatic duct ligation on exocrine pancreatic function and structure in the rabbit

4 weeks after pancreatic duct ligation in the rabbit, fecal and luminal chymotrypsin were detected in concentrations similar to the control group. Pancreatic changes in the ligated group were marked dilatation of the main pancreatic duct, proliferation and distention of ductules and fibrosis. Despite pancreatic duct ligation and fibrosis, proteolytic enzymes continued to secrete into the duodenal lumen. These results suggest that pancreatic duct ligation in the rabbit is not associated with total pancreatic insufficiency.     

Effect of pylorus ligation on gastric mucosal mast cell population in normal and adrenalectomised albino rats.

Pylorus ligation in normal albino rats acts like a stressor leading to degranulation of mast cells in gastric mucosa, thereby decreasing their number. This decrease is less pronounced when pylorus ligation is done in adrenalectomized rats. This implies that action of a stressor on gastric function involves the adrenal steroids which liberate the powerful gastric stimulant histamine from gastric mucosal mast cells.     

The acetylcholinesterase reaction and catecholamine fluorescence in the glomus cells of rat carotid body

Summary The presence of both acetylcholinesterase reaction and glyoxylic acid-induced fluorescence of catecholamines in the same glomus cells of rat carotid body was demonstrated using combined histochemical methods. A suggestion is made that the glomus cells have both excitatory and inhibitory effects on the chemosensory nerve via acetylcholine and catecholamines, respectively.Acknowledgments. The present study was supported by grants from the Emil Aaltonen Foundation and the Finnish Cancer Foundation to Timo Waris.     

Smooth muscle cells in ‘venous patches’ grafted into the rat common carotid artery. A structural study

Summary In the 2nd week after surgery, well differentiated smooth muscle cells (SMC) were evident in the walls of venous patches in rat common carotid artery. Gap junctions were the only type of intercellular junction observed between SMC in the present study.In memoriam to Prof. J. Cabré Piera.Acknowledgment. The LKB IV ultramicrotome was purchased with a grant from the Banco Urquijo, Madrid (Spain). Authors are also grate to M. Guerricabeitia for technical assistance.     

Effect of lesions of the locus coeruleus complex on the circadian rhythm of plasma corticosterone in the mouse.

An apparently transient elevation of basal morning (08.00 h) plasma corticosterone levels in male mice was found 48 h after bilateral electrolytic lesions of the brainstem locus coeruleus complex but was not observed 6 weeks after lesioning.     

Effects of 6-hydroxydopamine on rat carotid body chief cells

Summary Administration of 6-hydroxydopamine (6-OHDA) in concentrations high enough to cause degeneration of perivascular adrenergic nerve terminals has no morphological effect on the catecholamine-storing cells of the rat carotid body. Uptake of 6-OHDA by carotid body chief cells may be more selective than that exhibited by small-intenselyfluorescent cells and other catecholamine-storing cells which are affected by 6-OHDA. Alternatively, the sustentacular cells which envelope the chief cells may provide an effective barrier against the uptake of 6-OHDA.Supported by a Grant-in-Aid from the American Heart Association (77 630) and with funds contributed in part by the Texas Affiliate.     

Basal plasma corticosterone level after bilateral selective lesions of the olfactory pathways in the rat

In comparison to control rats, basal plasma corticosterone level and lactacidemia significantly increased in rats submitted to a bilateral lesion of the lateral olfactory tract and/or the anterior branch of the anterior commissure. Only the lesion of the anterior branch of the anterior commissure induced hyperglycemia; that of the lateral olfactory tract exerted an opposite effect.     

Pubertal changes in the medio-basal hypothalamic area after neonatal suprachiasmatic nucleus lesions in the rat

Summary In order to get more insight into the mechanism by which the onset of puberty is controlled, a developmental study on the displacement of catalase- and dopamine-containing cells in the hypothalamic region was done in rats which received a neonatal lesion of the suprachiasmatic nucleus. The displacement of cells is delayed after these lesions. However, the time lost at the beginning of the displacement is made up at the end of the migration.     

Pubertal changes in the medio-basal hypothalamic area after neonatal suprachiasmatic nucleus lesions in the rat

In order to get more insight into the mechanism by which the onset of puberty is controlled, a developmental study on the displacement of catalase- and dopamine-containing cells in the hypothalamic region was done in rats which received a neonatal lesion of the suprachiasmatic nucleus. The displacement of cells is delayed after these lesions. However, the time lost at the beginning of the displacement is made up at the end of the migration.