共查询到20条相似文献,搜索用时 31 毫秒
1.
Molecular coupling of Tsix regulation and pluripotency 总被引:1,自引:0,他引:1
Navarro P Oldfield A Legoupi J Festuccia N Dubois A Attia M Schoorlemmer J Rougeulle C Chambers I Avner P 《Nature》2010,468(7322):457-460
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Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome 总被引:32,自引:0,他引:32
N Brockdorff A Ashworth G F Kay P Cooper S Smith V M McCabe D P Norris G D Penny D Patel S Rastan 《Nature》1991,351(6324):329-331
X-chromosome inactivation in mammals is a regulatory phenomenon whereby one of the two X chromosomes in female cells is genetically inactivated, resulting in dosage compensation for X-linked genes between males and females. In both man and mouse, X-chromosome inactivation is thought to proceed from a single cis-acting switch region or inactivation centre (XIC/Xic). In the human, XIC has been mapped to band Xq13 (ref. 6) and in the mouse to band XD (ref. 7), and comparative mapping has shown that the XIC regions in the two species are syntenic. The recently described human XIST gene maps to the XIC region and seems to be expressed only from the inactive X chromosome. We report here that the mouse Xist gene maps to the Xic region of the mouse X chromosome and, using an interspecific Mus spretus/Mus musculus domesticus F1 hybrid mouse carrying the T(X;16)16H translocation, show that Xist is exclusively expressed from the inactive X chromosome. Conservation between man and mouse of chromosomal position and unique expression exclusively from the inactive X chromosome lends support to the hypothesis that XIST and its mouse homologue are involved in X-chromosome inactivation. 相似文献
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p53 is regulated by the lysine demethylase LSD1 总被引:1,自引:0,他引:1
Huang J Sengupta R Espejo AB Lee MG Dorsey JA Richter M Opravil S Shiekhattar R Bedford MT Jenuwein T Berger SL 《Nature》2007,449(7158):105-108
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Gontan C Achame EM Demmers J Barakat TS Rentmeester E van IJcken W Grootegoed JA Gribnau J 《Nature》2012,485(7398):386-390
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G Borsani R Tonlorenzi M C Simmler L Dandolo D Arnaud V Capra M Grompe A Pizzuti D Muzny C Lawrence 《Nature》1991,351(6324):325-329
In mammals, equal dosage of gene products encoded by the X chromosome in male and female cells is achieved by X inactivation. Although X-chromosome inactivation represents the most extensive example known of long range cis gene regulation, the mechanism by which thousands of genes on only one of a pair of identical chromosomes are turned off is poorly understood. We have recently identified a human gene (XIST) exclusively expressed from the inactive X chromosome. Here we report the isolation and characterization of its murine homologue (Xist) which localizes to the mouse X inactivation centre region and is the first murine gene found to be expressed from the inactive X chromosome. Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation. 相似文献
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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development 总被引:2,自引:0,他引:2
Agger K Cloos PA Christensen J Pasini D Rose S Rappsilber J Issaeva I Canaani E Salcini AE Helin K 《Nature》2007,449(7163):731-734
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Large clusters of co-expressed genes in the Drosophila genome 总被引:6,自引:0,他引:6
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Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive 总被引:1,自引:0,他引:1
Guccione E Bassi C Casadio F Martinato F Cesaroni M Schuchlautz H Lüscher B Amati B 《Nature》2007,449(7164):933-937
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Structure and regulatory function of plant transcription factors 总被引:4,自引:0,他引:4
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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling 总被引:1,自引:0,他引:1
Wysocka J Swigut T Xiao H Milne TA Kwon SY Landry J Kauer M Tackett AJ Chait BT Badenhorst P Wu C Allis CD 《Nature》2006,442(7098):86-90
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Peña PV Davrazou F Shi X Walter KL Verkhusha VV Gozani O Zhao R Kutateladze TG 《Nature》2006,442(7098):100-103
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Hornstein E Mansfield JH Yekta S Hu JK Harfe BD McManus MT Baskerville S Bartel DP Tabin CJ 《Nature》2005,438(7068):671-674