Chemist,entomologist, Darwinian,and man of affairs: Raphael Meldola and the making of a scientific career

In 1925 a debate erupted in the correspondence columns of the British Medical Journal concerning the effectiveness of eating raw pancreas as a treatment for diabetes. Enthusiasts were predominantly general practitioners (GPs), who claimed success for the therapy on the basis of their clinical impressions. Their detractors were laboratory‐oriented ‘biochemist‐physicians,’ who considered that their own experiments demonstrated that raw pancreas therapy was ineffective. The biochemist‐physicians consistently dismissed the GPs' observations as inadequately ‘controlled’. They did not define the meaning of ‘control’ in this context, although it clearly did not have the term's present‐day meaning of a trial employing an untreated comparison group of patients. Rather, the physician‐biochemists' ‘properly controlled’ experiments involved careful regulation of their patients' diet and other environmental factors, and evaluation of the therapy's success through biochemical, rather than just clinical, criteria. However, my analysis suggests that these factors alone are inadequate to account for the biochemist‐physicians' dismissal of the GPs' work as ‘uncontrolled’. I suggest that the biochemist‐physicians were deliberately exploiting the powerful rhetorical connotations of the term ‘control’. Ultimately, they implied that only a trial which they themselves had conducted could be deemed ‘adequately controlled’.     

Properties and causes: An approach to the problem of hypothesis in the scientific methodology of Sir Isaac Newton

This article considers the differential absorption and integration of refugee physicists into various countries during the 1930s, and the social and intellectual factors responsible for this, focusing particularly on the social functions of the British and American university at that period, as well as continuing ideological struggles in the Soviet Union. More generally, the issue of the relative absorption of refugee physicists is used to examine the nature of the physics communities and other institutions of the host societies.     

The career of continental drift theory: An application of Imre Lakatos' analysis of scientific growth to the rise of drift theory

The continental drift research programme reigns supreme within the geological community. The programme achieved its regal status only within the last decade. Its ascension to the summit took over fifty years, and required numerous switchbacks. Although its climb may seem haphazard, I argue that there is an overall rationale to its development which is partially elucidated by the account of scientific growth and change as put forth by Imre Lakatos. However, at least two alterations must be made in Lakatos' analysis. One concerns his analysis of ‘novel fact’, and the other is concerned with his thesis that the hard core of a research programme remains the same throughout the programme's lifetime. I consider and reject Elie Zahar's notion of ‘novel fact’, introduce an alternative notion of ‘novel fact’, and argue that Lakatos and his followers must abandon the thesis that a research programme's hard core is immune from change, but that they can do so without endangering Lakatos' overall account of scientific growth and change.     

Towards a science of the individual: the Aristotelian search for scientific knowledge of individual entities

This article seeks to take a step towards recognizing that science can deal with the concrete and individual as well as the universal. I shall concentrate on some of Aristotle’s texts, as there is a long tradition going back to Aristotle, according to which science deals only with the universal, although his work also contains texts of a very different tenor. He tries to improve the process of definition as an attempt to bring science closer to the concrete, but ends up realizing that there are some unreachable limits. There is, however, a second Aristotelian approach to the problem in Metaphysica M 10, a passage which takes scientific rapprochement to the individual further by introducing a distinction between science in potential and science in act. The former is universal, but the latter deals with individual substances and processes. Aristotle himself acknowledges here that in one sense science is universal and in another it is not, a position that raises important ontological and epistemological problems. Some suggestions are also offered concerning the kind of truth applicable to science in act, that is, practical truth.     

High poly A content of the native genome of murine oncornaviruses : presence of 65-70 S RNA lacking polyadenylic sequences]

High molecular weight Poly (A) minus RNA was isolated from native genome of murine oncornaviruses. The Poly (A) content of viral genomes seems to depend more on cellular multiplication than viral maturation.     

From successful measurement to the birth of a law: Disentangling coordination in Ohm's scientific practice

In this paper, I argue for a distinction between two scales of coordination in scientific inquiry, through which I reassess Georg Simon Ohm's work on conductivity and resistance. Firstly, I propose to distinguish between measurement coordination, which refers to the specific problem of how to justify the attribution of values to a quantity by using a certain measurement procedure, and general coordination, which refers to the broader issue of justifying the representation of an empirical regularity by means of abstract mathematical tools. Secondly, I argue that the development of Ohm's measurement practice between the first and the second experimental phase of his work involved the change of the measurement coordination on which he relied to express his empirical results. By showing how Ohm relied on different calibration assumptions and practices across the two phases, I demonstrate that the concurrent change of both Ohm's experimental apparatus and the variable that Ohm measured should be viewed based on the different form of measurement coordination. Finally, I argue that Ohm's assumption that tension is equally distributed in the circuit is best understood as part of the general coordination between Ohm's law and the empirical regularity that it expresses, rather than measurement coordination.     

Neurath’s protocol statements revisited: sketch of a theory of scientific testimony

This paper puts forward a significant revision of the interpretation of Neurath’s proposal for the form and content of so-called protocol sentences that was given by the author some years ago. Importantly, it eschews the ambition to give necessary and sufficient conditions for Neurath’s explicandum and instead aims merely to provide a characterisation of central cases. Even more importantly, it refocusses the explicandum from observation statements generally to observation reports and casts Neurath’s proposal in the form of an incipient theory of scientific testimony, in particular, testimony about observational evidence. In light of this analysis the paper then links Neurath’s proposal to current debates about the viability of Sellars’s anti-foundationalism and explores the nature of testimony and the justification of perceptual knowledge in science and everyday life.     

The sugar industry, political authorities, and scientific institutions in the regulation of saccharin: Valencia (1888-1939)

In the late-nineteenth century food production and trade were greatly transformed. Changes in the food chain gave rise to new problems connected with food safety and food quality, which caused new controls to be introduced throughout Europe. In this paper I will contribute to ongoing debates by focusing on the regulation of saccharin in an agrarian city in the south of Europe, Valencia. The laboratory-made sweetener was introduced into the food market at the turn of the century, becoming highly controversial shortly afterwards. Several local groups of players got involved in this dispute. The sugar industry was not only an important stakeholder in the passing of some specific laws that were to constrain the use of saccharin, but also the main driver of regulation, primarily in periods when saccharin could become a serious competitor and reduce the sector's profit. Furthermore, the combined work of the sugar industry and the municipal laboratories was essential for the implementation of regulations. It was in such municipal laboratories that scientists played a main role in regulation. My paper will address the commercial disputes linked to the use of saccharin and the limited role of science and scientists in its control.     

The statesman and the ophthalmologist: Gladstone and Magnus on the evolution of human colour vision, one small episode of the nineteenth-century Darwinian debate

Among the numerous nineteenth-century sorties into particular aspects of the Darwinian debate are two 1877 publications. The first, Die Geschichtliche Entwickelung des Farbensinnes, was a treatise on the evolutionary development of human colour vision by Hugo Magnus, an obscure German ophthalmologist. The other, The Colour-Sense, was an article by William Ewart Gladstone, the great British statesman. Magnus, working from linguistic science and optical physiology, developed the theory that humankind had passed through successive stages of colour recognition, from none to full perception, brightest colours first. Gladstone supported the theory with data from his studies of Homeric colour words, placing Homer at a very early stage. Their theory was not accepted. It assumed colour vocabulary to be an index of colour recognition, and too little was known about the nature or age of early man. The present study intends to follow this particular episode as an excellent example of the scholarship, argumentation, and limited scientific knowledge of the time, as applied to human evolution.