Costaclavine fromPenicillium chermesinum

Zusammenfassung Es wurden inPenicillium Mutterkornalkaloide nachgewiesen, die bisher nur unter den Pilzen ausAspergillus undClaviceps bekannt waren.

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For the identification of the species used in this investigation, I am indebted to Dr.J. R. Kinsley, Purdue University. The technical assistance of MissS. Roos and the financial support from the Swedish Natural Science Research Council was appreciated. The sample of authentic costaclavine was generously provided by Dr.M. Abe.     

Seasonal variations in testicular monoamine oxidase in the house sparrow (Passer domesticus) and uinta ground squirrels (Spermophilus armatus)

Résumé Des moinaux familiers (Passer domesticus) et des écureuils (Spermophilus armatus) des montagnes Uinta ont été capturés à différentes époques de l'année et l'activité de laMao a été mesurée dans leurs testicules. Chez les deux espèces l'activité de la MAO était la plus grande lorsque le poids des testicules était le plus élevé et la plus basse avant et après la saison du rut. Chez le moineau, l'augmentation de l'activité de MAO a précédé le développement des testicules.

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We thank the Atomic Energy Commission Grant No. At(11-1)-1602, Utah State University research project No. U-300 and Ecol. Grant No. 19 for their support of this research.R. L. Urry, present address: Division of Urology, University of Rochester, School of Medicine and Dentistry, Rochester, New York, 14642.J. L. Frehn was on sabbatical leave from his present position in the Department of Biology, Illinois State University, Normal, Illinois, 61761. We thankPhyllis Tayler for her technical help in this investigation.     

In vitro induction of vegetative buds by tobacco smoke condensate

Zusammenfassung Es wird gezeigt, dass wasserlösliche Extrakte aus Tabakrauchkondensaten vegetative Keimlinge auf Kallusstücken aus Stämmen von haploiden Tabakpflanzen (Nicotiana tabacum) induzieren und dass der gleiche Effekt mit Kinetin und 3-Indolessigsäure erzielt werden kann.

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This study was carried out under contract No. 12-14-100-341(73) with the Agricultural Research Service, U.S. Department of Agriculture, administered by the Eastern Utilization Research Development Division, Philadelphia.

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The authors are thankful to Dr.R. B. Griffith, Director, Tobacco and Health Research Institute, University of Kentucky, for critical review of this paper and valuable suggestions.     

Antiviral substances in starfish

Zusammenfassung Eine Gruppe von teilweise chemisch charakterisierten Verbindungen, welche die Vermehrung des Influenza-Virus in Huhnembryo-Test verhindern, wurde aus den SeesternenAsterias forbesi, Asterias pectinifera undAcanthaster planci isoliert.

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This research was supported by the N.S.F. Sea-Grant Program. The author thanks Dr.H. W. Younken Jr. and Dr.L. R. Worthen for their encouragement and suggestions throughout this work. Thanks are also due to Dr.Hashimoto, Tokyo University, and Dr.Yasumoto, Tohoku University, for the specimen ofAsterina pectinifera, and Dr.B. M. Branham, University of Hawaii, forAcanthaster planci sample. The antiviral test was carried out by Dr.O. Liu, Northeast Shellfish Sanitation Research Center, D. H. E. W., Narragansett, Rhode Island, to whome the author expresses his sincere gratitude.     

Effect of specific antibodies onNeisseria catarrhalis (lys−) transformation frequency

Zusammenfassung Antikörper mit einer gegen kompetenteN. catarrhalis gerichteten Spezifität vermindern deren Transformationshäufigkeit bedeutend. Diese Beobachtung könnte auf die Existenz von Membranrezeptoren für transformierende Wildtyp-DNS hinweisen.

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This investigation was supported by the Research Corporation of Chicago No. 40-84 and Eastern Kentucky University Research Grant No. 05-03-422-41.     

Cytochemical demonstration of ‘marker’ enzymes in nerve cells cultured in vitro

Zusammenfassung Die Enzymaktivität des Nervengewebes in Kulturen wird untersucht um funktionelle und morphologische Befunde zu vergleichen. Es werden sogenannte «Marker» Enzyme beschrieben sowie deren histochemische und färberische Darstellung.

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This work was done at the Department of Anatomy (Director, Dr. M.Okamoto), Faculty of Medicine, Kyoto University, Kyoto; and Laboratory for Cell Physiology (Director, Dr. M. R.Murray), Department of Surgery, College of Physicians and Surgeons, Columbia University, New York. The work at Columbia University was supported by a Post-doctoral fellowship from National Multiple Sclerosis Society.     

On the stability of bilirubin

Riassunto Gli autori hanno studiato l'azione della luce sulla stabilità della bilirubina in soluzione alcalina e in soluzione cloroformica. Viene proposto, in via generate, un meccanismo del primo ordine per la trasformazione della bilirubina in pigmenti verdinoidi, sia per le soluzioni irradiate, sia per quelle conservate al buio.

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Research carried out with CNR financial support. A report on this investigation, with more detailed experimental data, has been published in Acta medica romana (Annali della Facoltà di Medicina e Chirurgia dell'Università Cattolica del Sacro Cuore in Roma)2, 192 (1964).

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We are indebted to Prof. P.Fasella, University of Rome, and to Prof. A.Vaciago, Sacred Heart Catholic University Medical School, for their helpful suggestions and constructive criticisms. One of us (I. W. de E.) is also grateful to Prof. Ing. W. S.Hill, University of Montevideo, for his suggestion to her to investigate bilirubin spectroscopically.     

Evidence for selective adsorption and polymerization of thel-optical isomers of amino acids relative to thed-optical isomers on the edge faces of kaolinite

Zusammenfassung Auf Kaolinitkristallen werden diel-optischen Isomeren der Aminosäuren vollständiger adsorbiert und schneller polymerisiert als died-optischen Isomeren.

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The research as supported by a post-doctoral fellowship awarded by the School of Forestry, Yale University, New Haven (Conn., USA). I thank Dr. G. E.Hutchinson (Yale University) for helpful coments, and Dr. G. W.Brindley (Pennsylvania State University) for technical suggestions.     

Position of the methionine residue in bovine neurophysin II

Zusammenfassung Durch Spaltung mit CNBr wurde gezeigt, dass Neurophysin II aus Rinderhypophyse nur eine Methionin-Einheit enthält und dass die N-terminale Sequenz Ala-Met ist.

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This work was supported by NIH Grants No. AM-13567, No. AM-10080, by NSF Grant No. GB-17046 and by the City University of New York. The authors are indebted to Dr.L. Abrash for helpful discussion and MissM. Wahrenburg and Mr.V. S. Sapirstein for the assays.

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Predoctoral fellow of the Department of Physiology.     

Inhibition of thyroid function following the administration of metopiron (SU-4885)

Zusammenfassung Die Goitrogen-Wirkung des Metopirons (SU-4885, CIBA) wurde in Feld- und Wüstenmaus mittels radioaktiven I¹³¹ untersucht. Das radioiodingebundene Protein (Pb I¹³¹) war nach SU-4885 vermindert. Die Zunahme der gesamten Radioaktivität in der Schilddrüse lag bei 49%. Metopiron wirkt als Schilddrüsen-Hemmer.

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We are grateful to Prof.P. N. Srivastava for providing facilities. The investigation was supported by University Grants Commission, New Delhi, India.     

Isocardenolides

Zusammenfassung Ein einfacher Weg zur Synthese eines von zwei möglichen isomeren Cardenoliden wurde entwickelt und die Reaktionsfolge an Hand der Überführung von Pregnenolon in Isocardenolide V gezeigt.

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Steroids and Related Natural Products XXI. For the previous contribution refer to:G. R. Pettit andP. Hofer, Helv. chim. Acta46, 2142 (1963).

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A preliminary account of this study was presented (December 1963) at the VI. Pan-American Congress of Pharmacy and Biochemistry, Mexico City (Mexico).

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This investigation was supported by PHS Research Grants CY-4074 (C3) to CA-04074-06 from the National Cancer Institute, Public Health Service.     

Analysis of vasodilatation in the submaxillary gland using potentiators of acetylcholine and kinins

Zusammenfassung Nachweis, dass bei Reizung des N. chorda lingualis der Katze ein Blutdruckeffekt ausbleibt, wenn ein Bradykinin potenzierender Faktor (Präparat BPF) zuvor gegeben wurde.

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Acknowledgments. We are greatly indepted to Dr.J. Stewart of the University of Colorado and to Dr.L. Greene of Brookhaven National Laboratories, New York, for kind gifts of synthetic bradykinin potentiators.

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This work was supported by grants from the Medical Research Council of Canada and the Alberta Heart Foundation.     

Varying degrees of ventromedial hypothalamic destruction in the weanling rat and its effect on plasma triglyceride and cholesterol levels

Zusammenfassung Es wurden ein- und dreipaarige elektrolytische Läsionen in den ventromedialen Kernen von Ratten gesetzt, wobei es zu einer Erhöhung von Triglyceriden und Cholesterin kam. Dieses Hypothalamus-Gebiet enthält Regulationszentren des Serumlipidspiegels.

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This investigation was supported in part by Grants from the United States Public Health Service No. HD 03331, from the American Heart Association and the Mid-Hudson Heart Association.

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Acknowledgments. The authors express their gratitude to Mrs.B. Stone, MissD. Hojnicki and Mr.P. Stanley for their excellent technical assistance.     

Aging of collagen in complex tissues. A micromethodological study of the thermal reaction

Zusammenfassung Die Messung des Denaturationsdunktes als Parameter für die thermale Reaktion des Kollagens in geometrisch komplexen Geweben oder von Kollagenen verschiedener Reifegrade wird beschrieben und Beispiele im Bereich von Altersunterschieden und Wundheilung werden gegeben.

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This work was supported by Swedish Medical Research Council (Project No. B70-12X-2883-01) and by Carin Trygger Memorial Fund through the Swedish Society of Medical Sciences and performed at the Department of Anatomy, University of Gothenburg, Sweden.

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The technical assistance of MissUlla-Britt Lindgren in the development of this method is gratefully acknowledged.     

Steroidal peptides

Zusammenfassung Es wird die Möglichkeit erwogen, dass Steroide mit geeignet gebauten Peptidseitenketten am Aufbau oder Transport von Hormonen beteiligt sein könnten. Über die erstmalige Darstellung von Steroidpeptiden wird berichtet. Als Beispiele werden die Synthesen der beiden geschützten Steroidpeptide III und IV beschrieben.

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Part XXIV of a series entitledSteroids and Related Natural Products. For the preceding contribution see:J. P. Kutney, W. Cretney, G. R. Pettit, andJ. C. Knight, Tetrahedron, in press.

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A preliminary report of this study was presented (April 9, 1964) at the Third International Symposium on the Chemistry of Natural Products, Kyoto (Japan).

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This investigation was supported by National Science Foundation Research Grant GB-249.     

Central glucoprivation: Some physiological effects induced by the intraventricular administration of 2-deoxy-d-glucose

Riassunto Il 2-desossi-d-glucosio somministrato nel ventricolo laterale del cervello del ratto provoca iperglicemia, inibizione della secrezione di insulina, iperfagia ed ipotermia a dosi che sono inefficaci per via sistemica.

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MissesF. Ferrari, S. Bianchi andL. Scapellato provided skilful technical assistance. This investigation was supported by Grant No. 70.01788.04115.2380 of the Consiglio Nazionale delle Richerche, Italy.     

Release of deoxyuridine by shope virus induced papilloma and Vx-2 carcinoma cells into the incubation medium

Zusammenfassung Virusinduzierte Tumorzellen geben im Gegensatz zu normalen Hautzellen Deoxyuridin ins Medium ab.

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This work forms part of the dissertation submitted by the author to the University of Tennessee, USA, in partial fulfilment of the requirements for the degree of doctor of philosophy.

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The author is grateful to Dr.St. Rogers for his guidence and help in this work.     

Daily variations in pigeon cropsac responses to prolactin

Zusammenfassung Es wird festgestellt, dass die Ansprechbarkeit des Taubenkropfsackes auf Prolactin in Abhängigkeit vom hormonalen Zustand des Versuchstieres von Tag zu Tag verschieden ist.

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Our study was supported by a Public Health Service Research Grant No. 5 R01 AM13400 and a Public Health Service Research Career Development Award No. GM-17, 898, toAlbert H. Meier. The ovine prolactin was a gift of the Endocrinology Study Section of the National Institutes of Health. We thank Dr.P. E. Schilling of the Computer Center at Louisiana State University for making the statistical evaluations.     

Interactions of anti-DNA antibodies with dinitrophenyl- and other hapten-protein-conjugates

Zusammenfassung Kreuzreaktionen mit Dinitrophenyl-, Pyrimidin-, Purin- sowie Nucleosid- und Nucleotid-Protein-Konjugaten konnten bei Antikörpern gegen DNS, wie sie im Serum von Patienten mit Lupus erythematodes auftreten, nachgewiesen werden. Diese Resultate sind möglicherweise von Bedeutung für die Interpretation der auffällig hohen Frequenz von Paraproteinen, welche mit Dinitrophenylverbindungen reagieren.

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Acknowledgments. The authors wish to thank MissE. Ischi for her excellent technical assistance, Dr.H. W. Baenkler (Erlangen) and Prof.P. H. Lambert (Geneva) for sera of patients with SLE.

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This investigation was supportec by the Swiss National Foundation for Scientific Research.