Historical survey of the japanning trade.—1. Eastern and western lacquer

Die Entwicklung des Schalenmodells, deren Skizzierung an dieser Stelle abgebrochen wird, unterteilt sich deutlich in mehrere zeitlich voneinander getrennte Phasen. Ausgangspunkt der Entstehung des Schalenmodells ist die Betrachtung der bekannten Isotope, die erst mit der Entdeckung des Neutrons die schon vorhandene Idee des Kernschalenaufbaus quantitativ erfaßbar macht, und zwar durch noch ungenau bekannte ausgezeichnete Zahlen (1932–1934). Wie oft in der Geschichte der Naturwissenschaften wird eine solche erste Phase durch verschiedene spekulative Annahmen begleitet, die sich auf wenige Anhaltspunkte stützen müssen. Bereits 1933 setzt eine andere Entwicklung ein, die neben der Darstellung empirischer Ergebnisse durch den Versuch gekennzeichnet ist, eine theoretische Begründung des Schalenmodells mit verschiedenen Kernpotentialen zu lieform. Es gelingt jedoch nicht, alle aufgetretenen Fragen befriedigend zu klären.

Deutlich getrennt von der Entwicklung der ersten Jahre beginnt erst 1948 eine weitere Entstehungsphase des Schalenmodells. Im Unterschied zur den Jahren 1932–35 liegt 1948 eine Fülle empirischen Materials vor, dessen Erklärung erneut zur Betrachtung eines Schalenmodells anregt. Damit gelingt es, die meisten der offenen Fragen im wesentlichen mit Hilfe der Kernpotentiale und einer starken Spin-Bahn-Wechselwirkung zu beantworten.     

Striated inclusions and defective mitochondria in the restricted form of the ‘amycelial’ mutant ofNeurospora crassa

Summary The cytoplasm of the restrictive form of the amycelial mutant ofNeurospora crassa, growing on sucrosemedium, contains paracrystalline, microfilamentous inclusions and mitochondria with internal membranous whorls lacking in acetate-grown cultures.The support of the Fonds national suisse de la recherche scientifique is gratefully acknowledged.     

Listening in Circles. Spoken Drama and the Architects of Sound, 1750–1830

The establishment of the discipline of architectural acoustics is generally attributed to the physicist Wallace Clement Sabine, who developed the formula for reverberation time around 1900, and with it the possibility of making calculated prognoses about the acoustic potential of a particular design. If, however, we shift the perspective from the history of this discipline to the history of architectural knowledge and praxis, it becomes apparent that the topos of ‘good sound’ had already entered the discourse much earlier. This paper traces the Europe-wide discussion on theatre architecture between 1750 and 1830. It will be shown that the period of investigation is marked by an increasing interest in auditorium acoustics, one linked to the emergence of a bourgeois theatre culture and the growing socio-political importance of the spoken word. In the wake of this development the search among architects for new methods of acoustic research started to differ fundamentally from an analogical reasoning on the nature of sound propagation and reflection, which in part dated back to antiquity. Through their attempts to find new ways of visualising the behaviour of sound in enclosed spaces and to rethink both the materiality and the mediality of theatre auditoria, architects helped pave the way for the establishment of architectural acoustics as an academic discipline around 1900.     

The Quantification and Differentiation of the Drug Receptor Theory,c. 1910–1960

While historians have dealt with the origins of the concept of drug receptors in the work of Paul Ehrlich (1854–1915) and John N. Langley (1852–1925) as well as with some of its applications in modern pharmaceutical research, the history of the receptor theory as such has been neglected. Discussing major developments and conceptual changes in receptor theory between about 1910 and 1960 (including relevant contributions by A. V. Hill, A. J. Clark, J. H. Gaddum, E. J. Ariëns and others), this paper attempts to fill this gap in historiography. It provides a case study of the unfolding of research under a new paradigm, but it considers also contemporary criticism and scepticism. By the early 1960s, quantitative investigations of drug action and interpretations of the experimental findings in terms of the receptor concept had become constitutive of the emerging field of ‘molecular pharmacology’. Even then, however, receptors were still hypothetical entities.