Resolving the nebulae: the science and art of representing M51

Astronomy has a long tradition of translating data into different visual representations and scholars have noted a division between ‘pretty pictures’ and scientific images. A series of drawings and engravings of M51 derived from Lord Rosse’s observations at Birr Castle and Hubble Space Telescope images of the same object offer an opportunity to examine shifts in the object’s representation within a given period, as well as over the long history of observing it. This demonstrates both the consistent interest of astronomy in structure and improved resolution, as well as the subjective treatment of light and color. Furthermore, while the distinction between ‘pretty pictures’ and scientific images offers a starting point for analyzing the translations within a given period, the line between the two blurs, suggesting the complexity of aesthetic choices within astronomical images.     

Failure of (+)-naloxone to accelerate feline colonic transit

To determine whether the colonic transit accelerating effect of (-)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.), was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors.     

Failure of (+)-naloxone to accelerate feline colonic transit

Summary To determine whether the colonic transit accelerating effect of (–)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.) was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors.     

Evidence from trade cards for the scientific instrument industry

Trade cards were a means of advertising products or services and thereby attracting customers to the owner's shop. They often included a variety of details about the proprietor and his business, and illustrated his wares. Cards for the scientific instrument industry depicted all classes of instrument and the products from which they were made. A careful study of the cards can reveal much supplementary information about the way the industry worked, so their use, and limitations, as a source of historical evidence is discussed in detail. Over sixty English trade cards from London and the provinces, covering the period 1670 to 1900, are illustrated (most of them previously unpublished). By careful analysis, it is shown that aesthetic style and type-face design, combined with written and pictorial content, may be used to deduce dates and business practices. Many small pieces of information gradually build a complex picture of an important and fascinating industry.     

Trust in expert testimony: Eddington's 1919 eclipse expedition and the British response to general relativity

The 1919 British astronomical expedition led by Arthur Stanley Eddington to observe the deflection of starlight by the sun, as predicted by Einstein's relativistic theory of gravitation, is a fascinating example of the importance of expert testimony in the social transmission of scientific knowledge. While Popper lauded the expedition as science at its best, accounts by Earman and Glymour, Collins and Pinch, and Waller are more critical of Eddington's work. Here I revisit the eclipse expedition to dispute the characterization of the British response to general relativity as the blind acceptance of a partisan's pro-relativity claims by colleagues incapable of criticism. Many factors served to make Eddington the trusted British expert on relativity in 1919, and his experimental results rested on debatable choices of data analysis, choices criticized widely since but apparently not widely by his British contemporaries. By attending to how and to whom Eddington presented his testimony and how and by whom this testimony was received, I suggest, we may recognize as evidentially significant corroborating testimony from those who were expert not in relativity but in observational astronomy. We are reminded that even extraordinary expert testimony is neither offered nor accepted entirely in an epistemic vacuum.     

Primary source knowledge and technical decision-making: Mbeki and the AZT debate

Demands for public participation in technical decision-making are currently high on the agenda of Science & Technology Studies. It is assumed that the democratisation of technical decision-making processes generally leads to more socially desirable and acceptable outcomes. While this may be true in certain cases, this assumption cannot be generalised. I will discuss the case of the so-called ‘South African AZT debate’. The controversy started when President Thabo Mbeki, after reading some scientific papers on the toxicity of AZT, decided to bar the use of the drug in the public health sector as a means to reduce the transmission of HIV from mothers to children. While the scientific mainstream accepts the effectiveness of AZT in reducing the risk of vertical HIV transmission, a few maverick scientists reject the clinical evidence and argue that the risks of using AZT by far outweigh its benefits. Based on various textual sources and using the ‘Periodic Table of Expertises’ developed by Collins and Evans, Mbeki’s expertise at the time of his intervention into the technical question whether AZT is a medicine or a poison can be classified as primary source knowledge. It is shown that this type of expertise is insufficient for technical decision-making. Mbeki’s primary source knowledge legitimated his presentation of the claims of maverick scientists as a serious contribution to the debate—with tragic consequences for tens of thousands of babies.     

Phenomenotechnique: Bachelard's critical inheritance of conventionalism

The concept of phenomenotechnique has been regarded as Bachelard's most original contribution to the philosophy of science. Innovative as this neologism may seem, it benefited from a generation of debates on the nature and status of scientific facts, among conventionalist thinkers and their opponents. Granting that Bachelard stood among the opponents to conventionalism, this article nonetheless reveals deep similarities between his work and that of two conventionalist thinkers who insisted on what we call today the theory-ladenness of scientific experiment: Pierre Duhem and Édouard Le Roy. This article, therefore, compares Bachelard's notion of phenomenotechnique with Duhem's developments on the double character of scientific instruments, and with Le Roy's claim that scientific facts are fabricated to meet the requirements of theory. It shows how Bachelard retained Duhem and Le Roy's views on the interplay between theory and experiment but rejected their sceptical conclusions on the limitations of experimental control. It claims that this critical inheritance of conventionalism was made possible by a reflection on technology, which led Bachelard to re-evaluate the artificiality of scientific facts: instead of regarding this artificiality as a limitation of science, as Le Roy did, he presented it as a condition for objective knowledge.     

Lavoisier and his Last Printed Work: The Mémoires de physique et de chimie (1805)

On the basis of a significant number of unpublished documents, here published for the first time, the article reconstructs the historical and scientific origins of Lavoisier's Mémoires de physique et de chimie. Because of the paucity of primary sources available so far, this work has previously received little attention and its 'publication' is commonly attributed to Madame Lavoisier's effort to revive the memory of her husband. In contrast with this image, this article suggests that Madame Lavoisier had only a subsidiary role and that Armand Séguin's contribution to both the editing and the scientific organization of the Mémoires needs a historical reassessment. Lavoisier's collaboration with Séguin, dating from 1792, resulted in a work the aim of which was far more ambitious than that of collecting already published memoirs. Furthermore, it is argued that the contents of the first volume of the Mémoires indicate an important evolution in Lavoisier's chemical theory.     

Etude radiographique du transit intestinal chez un Termite supérieur

Summary Intestinal transit inMicrocerotermes edentatus (Amitermitinae) lasts about 24 h. It is uni-directional and rapid up to the first pouch of the hindgut. The second pouch, which takes up 8–12 h, is undoubtedly equivalent to the rectal pouch of the lower termites.     

Overlapping ontologies and Indigenous knowledge. From integration to ontological self-determination

Current controversies about knowledge integration reflect conflicting ideas of what it means to “take Indigenous knowledge seriously”. While there is increased interest in integrating Indigenous and Western scientific knowledge in various disciplines such as anthropology and ethnobiology, integration projects are often accused of recognizing Indigenous knowledge only insofar as it is useful for Western scientists. The aim of this article is to use tools from philosophy of science to develop a model of both successful integration and integration failures. On the one hand, I argue that cross-cultural recognition of property clusters leads to an ontological overlap that makes knowledge integration often epistemically productive and socially useful. On the other hand, I argue that knowledge integration is limited by ontological divergence. Adequate models of Indigenous knowledge will therefore have to take integration failures seriously and I argue that integration efforts need to be complemented by a political notion of ontological self-determination.     

Boyle and the origins of modern chemistry: Newman tried in the fire

William Newman construes the Scientific Revolution as a change in matter theory, from a hylomorphic, Aristotelian to a corpuscular, mechanical one. He sees Robert Boyle as making a major contribution to that change by way of his corpuscular chemistry. In this article it is argued that it is seriously misleading to identify what was scientific about the Scientific Revolution in terms of a change in theories of the ultimate structure of matter. Boyle showed, especially in his pneumatics, how empirically accessible, intermediate causes, as opposed to ultimate, mechanical ones can be explored and identified by experiment. Newman is right to observe that Boyle constantly sought intimate links between chemistry and the mechanical philosophy. However, by doing so he did not thereby significantly aid the cause of attaining experimental knowledge of chemical phenomena and the support that Boyle’s chemistry provided for the mechanical philosophy was weaker than both Boyle and Newman imply. Boyle was intent on articulating and defending a strict, mechanical account of the ultimate structure of matter to be sure, but his contributions to the new experimental science in general, and chemistry in particular, are best seen as distinct from that endeavour.     

Styles of reasoning: A pluralist view

Styles of reasoning are important devices to understand scientific practice. As I use the concept, a style of reasoning is a pattern of inferential relations that are used to select, interpret, and support evidence for scientific results. In this paper, I defend the view that there is a plurality of styles of reasoning: different domains of science often invoke different styles. I argue that this plurality is an important source of disunity in scientific practice, and it provides additional arguments in support of the disunity claim. I also contrast Ian Hacking’s broad characterization of styles of reasoning with a narrow understanding that I favor. Drawing on examples from molecular biology, chemistry and mathematics, I argue that differences in style of reasoning lead to differences in the way the relevant results are obtained and interpreted. The result is a pluralist view about styles of reasoning that is sensitive to nuances of inferential relations in scientific activity.     

An appraisal of Mendeleev’s contribution to the development of the periodic table

Historians and philosophers of science generally conceptualize scientific progress to be dichotomous, viz., experimental observations lead to scientific laws, which later facilitate the elaboration of explanatory theories. There is considerable controversy in the literature with respect to Mendeleev’s contribution to the origin, nature, and development of the periodic table. The objectives of this study are to explore and reconstruct: a) periodicity in the periodic table as a function of atomic theory; b) role of predictions in scientific theories and its implications for the periodic table; and c) Mendeleev’s contribution: theory or an empirical law? The reconstruction shows that despite Mendeleev’s own ambivalence, periodicity of properties of chemical elements in the periodic table can be attributed to the atomic theory. It is argued that based on the Lakatosian framework, predictions (novel facts) play an important role in the development of scientific theories. In this context, Mendeleev’s predictions played a crucial role in the development of the periodic table. Finally, it is concluded that Mendeleev’s contribution can be considered as an “interpretative” theory which became “explanatory” after the periodic table was based on atomic numbers.     

Gastrointestinal transit and digestibility of maltitol, sucrose and sorbitol in rats: a multicompartmental model and recovery study.

Using data obtained with a dye marker and the gavage technique, the kinetics of gastrointestinal transit of different loads of sugar substitutes (maltitol, sorbitol) and sugar (sucrose) in the rat were analysed using a linear multicompartmental model over a range from the realistic to the non-physiologic high, of carbohydrate intake levels and using only a few experimental time points. The model gave detailed insight into intestinal propulsion and gastrocecal transit time. Rate constants of transport between the compartments investigated were determined; they showed characteristics which could be related to the substance and the dosage administered. Analyses of the gastrointestinal content and calculations of the intestinal net water movement showed that the digestibility and absorption of the disaccharide sugar alcohol, maltitol, in the small gut depended inversely on the dose ingested. For all substances tested, caloric availability in the small intestine was calculated. At a physiological low level of maltitol intake, the results also indicated an insignificant calorie-saving effect in comparison to sucrose, an effect based mainly on the slow absorption rate of the maltitol cleavage product sorbitol.     

Normativity,the base-rate fallacy,and some problems for retail realism

Recent literature in the scientific realism debate has been concerned with a particular species of statistical fallacy concerning base-rates, and the worry that no matter how predictively successful our contemporary scientific theories may be, this will tell us absolutely nothing about the likelihood of their truth if our overall sample space contains enough empirically adequate theories that are nevertheless false. In response, both realists and anti-realists have switched their focus from general arguments concerning the reliability and historical track-records of our scientific methodology, to a series of specific arguments and case-studies concerning our reasons to believe individual scientific theories to be true. Such a development however sits in tension with the usual understanding of the scientific realism debate as offering a second-order assessment of our first-order scientific practices, and threatens to undermine the possibility of a distinctive philosophical debate over the approximate truth of our scientific theories. I illustrate this concern with three recent attempts to offer a more localised understanding of the scientific realism debate—due to Stathis Psillos, Juha Saatsi, and Kyle Stanford—and argue that none of these alternatives offer a satisfactory response to the problem.     

Packaging radium, selling science: boxes, bottles and other mundane things in the world of science

This article discusses the intersection of science and culture in the marketplace and explores the ways in which radium quack and medicinal products were packaged and labelled in the early twentieth century US. Although there is an interesting growing body of literature by art historians on package design, historians of science and medicine have paid little to no attention to the ways scientific and medical objects that were turned into commodities were packaged and commercialized. Thinking about packages not as mere containers but as multifunctional tools adds to historical accounts of science as a sociocultural enterprise and reminds us that science has always been part of consumer culture. This paper suggests that far from being receptacles that preserve their content and facilitate their transportation, bottles and boxes that contained radium products functioned as commercial and epistemic devices. It was the 1906 Pure Food and Drug Act that enforced such functions. Packages worked as commercial devices in the sense that they were used to boost sales. In addition, 'epistemic' points to the fact that the package is an artefact that ascribes meaning to and shapes its content while at the same time working as a device for distinguishing between patent and orthodox medicines.     

A. M. Mayer's experiments with floating magnets and their use in the atomic theories of matter

In the years 1878 and 1879 the American physicist Alfred Marshall Mayer (1836–1897) published his experiments with floating magnets as a didactic illustration of molecular actions and forms. A number of physicists made use of this analogy of molecular structure. For William Thomson they were a mechanical illustration of the kinetic equilibrium of groups of columnar vortices revolving in circles round their common centre of gravity (1878). A number of modifications of Mayer's experiments were described, which gave configurations which were more or less analogous to Mayer's arrangements. It was Joseph John Thomson who, in publications between 1897 and 1907, used Mayer's results to obtain a good deal of insight into the general laws which govern the configuration of the electrons in his atomic model. This article is mainly concerned with Mayer's experiments with floating magnets and their use by a number of physicists. Through his experiments Mayer made a significant, although small, contribution to the theory of atomic structure.     

‘Revolutions,philosophical as well as civil’: French chemistry and American science in Samuel Latham Mitchill’s Medical Repository

ABSTRACT

From 1797 to 1801 a controversy played out on the pages of the Medical Repository, the first scientific journal published in the United States. At its centre was the well-known feud between the followers of Antoine Lavoisier and Joseph Priestley, the lone supporter of the phlogiston model. The American debate, however, had more than two sides. The Americans chemists, Samuel Latham Mitchill and Benjamin Woodhouse, who rushed to support Priestley did not defend his scientific views. Rather, as citizens of a republic, they defended his right to have them. They also castigated the assertions of the “French chemists,” whose claims that the new chemistry obviated debate seemed unsettlingly similar to the dictatorial ambitions of the French state. Using the Medical Repository, Mitchill and Woodhouse sought a compromise that validated the new chemistry, but united it with a more egalitarian form of discourse. The desired balance eluded them. Priestley proved too stubborn, and as the French Revolution descended into dictatorship and war, Mitchill and Woodhouse came more to realize that truly prising French chemistry from the culture of the revolutionary era. The episode left Mitchill and Woodhouse disillusioned with chemistry and hoping to redirect scientific enthusiasm to more pious ends.