The Archaean controversy in Britain: Part II—The Malverns and Shropshire

An account is given of early geological researches in the Malverns, the Church Stretton area, and the Wrekin. The reconnaissance work of Murchison suggested that each of these areas had Silurian sediments, intruded by igneous rocks (called trap or syenite). The early Survey maps were compiled on this theoretical basis, with the result that the Silurian sediments were regarded as the oldest rocks in Shropshire and the Malverns. Local geologists, working in the three areas, and with sufficient time to study the exposures in detail, began to develop the idea of ‘islands’ of Precambrian (Archaean) rock (perhaps showing some stratification), having younger sediments deposited thereon. This Archaean model was taken up and actively developed, and the stratigraphical details worked out, with the island model being gradually modified. Debates were stronger between members of the ‘Archaean’ fraternity than with the Survey. Traces of trilobite remains were found by Callaway at Comley, near Caer Caradoc, and were identified by Lapworth as Olenellus, enabling the underlying Wrekin Quartzite to be established as the base of the Cambrian, in agreement with ideas developed in North America and Scandinavia. Arguments are detailed concerning the relative ages of the ‘Uriconian’ and ‘Longmyndian’ rocks, and their constituent units. Both were agreed to be Precambrian, but the evidence in terms of field mapping, in relation to the Wrekin Quartzite, is not complete. The problems of stratigraphical work in unfossiliferous rocks are displayed, and also the efforts to achieve correlations with areas such as Pembrokeshire and Anglesey are described. Though consensus has been reached on the Precambrian status of the Malvernian, Uriconian and Longmyndian rocks, radiometric age determinations and other evidence throw doubt on some aspects of the consensus, and research continues.     

The structure and interpretation of cosmology: Part I—general relativistic cosmology

The purpose of this work is to review, clarify, and critically analyse modern mathematical cosmology. The emphasis is upon mathematical objects and structures, rather than numerical computations. This paper concentrates on general relativistic cosmology. The opening section reviews and clarifies the Friedmann–Robertson–Walker models of general relativistic cosmology, while Section 2 deals with the spatially homogeneous models. Particular attention is paid in these opening sections to the topological and geometrical aspects of cosmological models. Section 3 explains how the mathematical formalism can be linked with astronomical observation. In particular, the informal, observational notion of the celestial sphere is given a rigorous mathematical implementation. Part II of this work will concentrate on inflationary cosmology and quantum cosmology.     

The archaean controversy in britain: Part IV—Some general theoretical and social issues

The main theoretical issues in the study of the history of the Archaean Controversy in Britain, which arose in the first three papers of the present series, are summarized and discussed—in particular the problem of stratigraphical work in rocks where no fossils can be discerned. The ‘Archaean’ geologists showed some leanings towards Neo-Neptunism and this, together with the fact that their work challenged the Murchison/Survey view of British geology, was one of the reasons for the controversy. At a deeper level, however, the question concerned the doctrine of uniformitarianism: Were metamorphic rocks to be found at any part of the stratigraphical column, or were they confined to the earliest period of the Earth's history? The establishment of the concept of Precambrian rocks and a suitable stratotype boundary is essentially a social question that has to be determined within the geological community. Some of the social processes whereby these matters are decided internationally are considered, and it is noted that the best location of the ‘Golden Spike’ for the Precambrian/Cambrian boundary has only just been settled (by vote). The paper also explores some nineteenth-century ideas about the nature of metamorphism, and the early conditions of the world.     

Horticulture in Portugal 1850–1900: The role of science and public utility in shaping knowledge

In this paper, we address the emergence of horticultural practice, agents, spaces and institutions in the two urban settings of Lisbon and Porto, in Portugal, during the second half of the nineteenth century. We do so by following the networking activities of two players: the self-made horticulturist and entrepreneur José Marques Loureiro, who created, in Porto, a commercial horticultural establishment and founded the Journal of Practical Horticulture; and the agronomist Francisco Simões Margiochi, head of the gardens and green grounds department of the municipality, who created the first course on gardening and horticulture, and founded the Royal Horticultural Society, both in Lisbon. Their joint activities were aimed at establishing horticulture as an applied science and to cater simultaneously to an extended audience of citizens. They enable us to enrich the narratives on the emergence and development of horticulture in Europe by calling attention to the participation in circulatory extended networks of actors who are often absent from these accounts. Additionally, they allow a comparative assessment of the outcome of their actions at the national level, and to understand their results in terms consonant with recent historiographical trends on the co-construction of centres and peripheries.

Abbreviations: AML – Arquivo Municipal de Lisboa (Municipal Archive of Lisbon).; ANTT – Arquivo Nacional da Torre do Tombo (National Archives at Torre do Tombo).; AHCPL – Arquivo Histórico da Casa Pia de Lisboa (Historical Archive of the Casa Pia of Lisbon).; JHP – Jornal de Horticultura Practica (Journal of Practical Horticulture). Online at: http://www.fc.up.pt/fa/?p=nav&;f=html.fbib-Periodico-oa&;item=378; BSNHP - Boletim da Sociedade Nacional de Horticultura de Portugal (Bulletin of the National Society of Horticulture of Portugal).     

EXORCIST XIV: The Wrath of Maxwell’s Demon. Part II. From Szilard to Landauer and Beyond

In this second part of our two-part paper we review and analyse attempts since 1950 to use information theoretic notions to exorcise Maxwell’s Demon. We argue through a simple dilemma that these attempted exorcisms are ineffective, whether they follow Szilard in seeking a compensating entropy cost in information acquisition or Landauer in seeking that cost in memory erasure. In so far as the Demon is a thermodynamic system already governed by the Second Law, no further supposition about information and entropy is needed to save the Second Law. In so far as the Demon fails to be such a system, no supposition about the entropy cost of information acquisition and processing can save the Second Law from the Demon.     

The C-terminal sequence of human and porcine antithrombin III and its homology with human α-1-proteinase inhibitor

Summary The C-terminal amino acid sequences of human and of porcine antithrombin III have been determined as Gly-Arg-Val-Ala-Asn-Pro-Cys-Val-Lys and Gly-Arg-Val-Ala-Asn-Pro-Cys, respectively. These sequences are highly homologous with the C-terminal sequence of human -1-proteinase inhibitor.     

Gauß and Beyond: The Making of Easter Algorithms

It is amazing to see how many webpages are devoted to the art of finding the date of Easter Sunday. Just for illustration, the reader may search for terms such as Gregorian calendar, date of Easter, or Easter algorithm. Sophisticated essays as well as less enlightening contributions are presented, and many a doubt is expressed about the reliability of some results obtained with some Easter algorithms. In short, there is still a great interest in those problems. Gregorian Easter algorithms exist for two centuries (or more?), but most of their history is rather obscure. Some reasons may be that some important sources are written in Latin or in the German of Goethe’s time, or they are difficult to discover. Without being complete, the following paper is intended to shed light on how those techniques emerged and evolved.¹ Like a microcosm, the history of Easter algorithms resembles the history of any science: it is a story of trials, errors, and successes, and, last but not least, a story of offended pride.     

The role of inflammation in sporadic and familial Parkinson’s disease

The etiology of Parkinson’s disease (PD) is complex and most likely involves numerous environmental and heritable risk factors. Interestingly, many genetic variants, which have been linked to familial forms of PD or identified as strong risk factors, also play a critical role in modulating inflammatory responses. There has been considerable debate in the field as to whether inflammation is a driving force in neurodegeneration or simply represents a response to neuronal death. One emerging hypothesis is that inflammation plays a critical role in the early phases of neurodegeneration. In this review, we will discuss emerging aspects of both innate and adaptive immunity in the context of the pathogenesis of PD. We will highlight recent data from genetic and functional studies that strongly support the theory that genetic susceptibility plays an important role in modulating immune pathways and inflammatory reactions, which may precede and initiate neuronal dysfunction and subsequent neurodegeneration. A detailed understanding of such cellular and molecular inflammatory pathways is crucial to uncover pathogenic mechanisms linking sporadic and hereditary PD and devise tailored neuroprotective interventions.