Brokering Instruments in Napoleon's Europe: The Italian Journeys of Franz Xaver von Zach (1807–1814)

This paper explores the interactions between scientific travel, politics, instrument making and the epistemology of scientific instruments in Napoleon's Europe. In the early 1800s, the German astronomer Franz Xaver von Zach toured Italy and Southern France with instruments made by G. Reichenbach in his newly-established Bavarian workshop. I argue that von Zach acted as a broker for German technology and science and that travel, personal contacts and direct demonstrations were crucial in establishing Reichenbach's reputation and in conquering new markets. The rise of German instrument making highlights the complexity of the scientific relationship between the centre and the peripheries in Napoleon's empire, and reveals the existence of diverging views on the role of instruments and of their makers. In von Zach's view, Reichenbach's instruments could not penetrate the French market because Parisian astronomers focused on mathematical astronomy and, for both political and epistemological reasons, dismissed instruments and material innovations from the peripheries. The German astronomer and his Italian colleagues, on the contrary, regarded Reichenbach's technical achievements as outstanding contributions to astronomy, and considered the political and cultural hegemony of the capital as a hindrance to the advancement of science.     

The platypus in Edinburgh: Robert Jameson,Robert Knox and the place of the Ornithorhynchus in nature, 1821–24

The duck-billed platypus, or Ornithorhynchus, was the subject of an intense debate among natural historians in the late eighteenth and early nineteenth centuries. Its paradoxical mixture of mammalian, avian and reptilian characteristics made it something of a taxonomic conundrum. In the early 1820s Robert Jameson (1774–1854), the professor of natural history at the University of Edinburgh and the curator of the University's natural history museum, was able to acquire three valuable specimens of this species. He passed one of these on to the anatomist Robert Knox (1791–1862), who dissected the animal and presented his results in a series of papers to the Wernerian Natural History Society, which later published them in its Memoirs. This paper takes Jameson's platypus as a case study on how natural history specimens were used to create and contest knowledge of the natural world in the early nineteenth century, at a time when interpretations of the relationships between animal taxa were in a state of flux. It shows how Jameson used his possession of this interesting specimen to provide a valuable opportunity for his protégé Knox while also helping to consolidate his own position as a key figure in early nineteenth-century natural history.     

Crossing the Olentangy River: The Figure of the Earth and the Military-Industrial-Academic-Complex, 1947–1972

This paper explores the history of a unique assemblage of researchers in the geodetic and allied sciences organised at Ohio State University (OSU) in 1947 at the beginning of the Cold War. From about 1950 to 1970, the OSU geodetic sciences group was the most significant group of geodetic researchers in the world. Funded almost entirely by military and intelligence agencies, they pioneered the technologies, organised the research initiatives, ordered the data sets, and trained the generation of geodesists who eventually created the Cold War Figure of the Earth to both prosecute and prevent global nuclear war. They devised elaborate mechanisms to pursue in secrecy and isolation research that had hitherto been performed collaboratively and globally. They invented methods to maintain professional associations and protocols, both to distribute—and disguise—the fruits of their geodetic research. In accomplishing this, their work also undermined the basic hypothesis of isostasy that had been foundational to geodesy for the previous century.Fundamental progress in the geosciences and military and intelligence directives were inextricably linked during the Cold War, although the extent of their convergence has been masked by the security protocols organised to disguise it. With the declassification of key programmes underway, it is now both possible and necessary to substantially revise the history of Cold War-era geosciences and their associated technologies.     

Science and the Mechanics' Institutes, 1820–1850: The case of Sheffield

This paper points out that the provincial mechanics' institutes of England in their early years were as much the product of a general and pervasive scientific culture as they were of a particular educational movement. To this extent the institutes can be interpreted within the context of wider social and economic changes. The bulk of the paper relates to the Mechanics' Institute at Sheffield in the period 1832–50, but through this and other material it is argued that this case study deserves general consideration.     

Poinsinet's Edition of the Naturalis historia (1771–1782) and the Revival of Pliny in the Sciences of the Enlightenment

This paper analyses the revival of Pliny's Naturalis historia within the scientific culture of the late eighteenth and early nineteenth centuries, focusing on a French effort to produce an edition with annotations by scientists and scholars. Between the Renaissance and the early eighteenth century, the Naturalis historia had declined in scientific importance. Increasingly, it was relegated to the humanities, as we demonstrate with a review of editions. For a variety of reasons, however, scientific interest in the Naturalis historia grew in the second half of the eighteenth century. Epitomizing this interest was a plan for a scientifically annotated, Latin-French edition of the Naturalis historia. Initially coordinated by the French governmental minister Malesherbes in the 1750s, the edition was imperfectly realized by Poinsinet a few decades later. It was intended to rival two of the period's other distinguished multi-volume books of knowledge, Diderot and D'Alembert's Encyclopédie and Buffon's Histoire naturelle, to which we compare it. Besides narrating the scientific revival of the Historia naturalis during this period, we examine its causes and the factors contributing to its end in the first half of the nineteenth century.     

C-terminal fragment (residues 61–91) ofβ-lipotropin: Is it the natural opiate-like neurohormon of the brain?

Summary The C-terminal fragment of porcine -lipotropin (residues 61–91) has a very strong analgesic activity in vivo in rats. It is 20 times more potent than morphine if administered intracerebroventricularly (ICV) to rats. Its effect could be antagonized by naloxone. Presumably it is a natural opiate-like neurohormon of the brain.     

The quest for the size of the universe in early relativistic cosmology (1917–1930)

Before the discovery of the expanding universe, one of the challenges faced in early relativistic cosmology was the determination of the finite and constant curvature radius of space-time by using astronomical observations. Great interest in this specific question was shown by de Sitter, Silberstein, and Lundmark. Their ideas and methods for measuring the cosmic curvature radius, at that time interpreted as equivalent to the size of the universe, contributed to the development of the empirical approach to relativistic cosmology. Their works are a noteworthy example of the efforts made by modern cosmologists toward the understanding of the universe as a whole, its properties, and its content.     

Horticulture in Portugal 1850–1900: The role of science and public utility in shaping knowledge

In this paper, we address the emergence of horticultural practice, agents, spaces and institutions in the two urban settings of Lisbon and Porto, in Portugal, during the second half of the nineteenth century. We do so by following the networking activities of two players: the self-made horticulturist and entrepreneur José Marques Loureiro, who created, in Porto, a commercial horticultural establishment and founded the Journal of Practical Horticulture; and the agronomist Francisco Simões Margiochi, head of the gardens and green grounds department of the municipality, who created the first course on gardening and horticulture, and founded the Royal Horticultural Society, both in Lisbon. Their joint activities were aimed at establishing horticulture as an applied science and to cater simultaneously to an extended audience of citizens. They enable us to enrich the narratives on the emergence and development of horticulture in Europe by calling attention to the participation in circulatory extended networks of actors who are often absent from these accounts. Additionally, they allow a comparative assessment of the outcome of their actions at the national level, and to understand their results in terms consonant with recent historiographical trends on the co-construction of centres and peripheries.

Abbreviations: AML – Arquivo Municipal de Lisboa (Municipal Archive of Lisbon).; ANTT – Arquivo Nacional da Torre do Tombo (National Archives at Torre do Tombo).; AHCPL – Arquivo Histórico da Casa Pia de Lisboa (Historical Archive of the Casa Pia of Lisbon).; JHP – Jornal de Horticultura Practica (Journal of Practical Horticulture). Online at: http://www.fc.up.pt/fa/?p=nav&;f=html.fbib-Periodico-oa&;item=378; BSNHP - Boletim da Sociedade Nacional de Horticultura de Portugal (Bulletin of the National Society of Horticulture of Portugal).     

The Rise and Fall of the Glassmaker Paul Bosc d'Antic (1753–1784)

Abstract

Thanks to the efforts made in the first decade of the 18th century by Réaumur and, to a lesser extent, by Buffon, glassmaking attracted the attention of Academic French scientists. In the early 1750s, in order to bridge the gap between the protected system of French glass manufactories and the academic thirst for innovation and technological improvement, technical experts with solid scientific backgrounds were charged by the Académie des sciences to supervise the organisation of several royal manufactories. Paul Bosc d'Antic was chosen in 1755 to solve the problems at the mirror manufactory in Saint-Gobain. Bosc d'Antic's career, in its tension between his ambition as an academic author and drive as a technical inventor, and the economic interest of a free entrepreneur, provides an interesting example of the complex and contradictory evolution of the French chemical arts and manufactories during the second half of the 18th century.

“Les arts ont entr'eux des rapports plus ou

moins marqués, […] mais celui de la verrerie

est le fondement de presque tous les autres”.

Bosc d'Antic     

The chemical versatility of the β–α–β fold: Catalytic promiscuity and divergent evolution in the tautomerase superfamily

Tautomerase superfamily members have an amino-terminal proline and a β–α–β fold, and include 4-oxalocrotonate tautomerase (4-OT), 5-(carboxymethyl)-2-hydroxymuconate isomerase (CHMI), trans- and cis-3-chloroacrylic acid dehalogenase (CaaD and cis-CaaD, respectively), malonate semialdehyde decarboxylase (MSAD), and macrophage migration inhibitory factor (MIF), which exhibits a phenylpyruvate tautomerase (PPT) activity. Pro-1 is a base (4-OT, CHMI, the PPT activity of MIF) or an acid (CaaD, cis-CaaD, MSAD). Components of the catalytic machinery have been identified and mechanistic hypotheses formulated. Characterization of new homologues shows that these mechanisms are incomplete. 4-OT, CaaD, cis-CaaD, and MSAD also have promiscuous activities with a hydratase activity in CaaD, cis-CaaD, and MSAD, PPT activity in CaaD and cis-CaaD, and CaaD and cis-CaaD activities in 4-OT. The shared promiscuous activities provide evidence for divergent evolution from a common ancestor, give hints about mechanistic relationships, and implicate catalytic promiscuity in the emergence of new enzymes. Received 22 May 2008; received after revision 20 June 2008; accepted 02 July 2008     

The chemists go to war: The mobilization of civilian chemists and the british war effort, 1914–1918

The outbreak of war in 1914 found Britain unprepared for a lengthy conflict. British science and industry were particularly ill-prepared to meet the demands of static warfare. Within two years, however, mobilization had made appreciable strides, and, as Britain's munitions industries moved from crisis to confidence, Britain's chemical industry was transformed by an arsenal of ‘garrison chemists’, with skills either born of necessity or borrowed from overseas. At the same time, Britain's chemical leadership traced a path that led them from voluntarist to corporate methods, from private to public initiatives, and from individual to collective behaviours. This paper suggests four key stages in this mobilization, and hints at the significance of the war for the emergence of new sub-disciplines, for the careers of chemists, for academic-government relations in research, and for the image, status, and international position of British chemistry on the threshold of the postwar world.     

Geometry of Light and Shadow: Francesco Maurolyco (1494–1575) and the Pinhole Camera

In his Theoremata de lumine, et umbre (1521), Francesco Maurolyco (1494–1575) discussed, inter alia, the problem of the pinhole camera. Maurolyco outlined a framework based on Euclidean geometry in which he applied the rectilinear propagation of light to the casting of shadow on a screen behind a pinhole. We limit our discussion to the problem of how the image behind an aperture is formed, and follow the way Maurolyco combined theory with instrument to solve the problem of the projection of light through small apertures. We show that Maurolyco not only reformed the classical sources which, he thought, were no longer the authoritative code of textual knowledge, but also established with the dioptra a novel linkage of method, theory, and instrument. He thereby demonstrated the importance of optics to the science of astronomy.     

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes

Type-2 diabetes mellitus (T2DM) is a disorder that is characterized by high blood glucose concentration in the context of insulin resistance and/or relative insulin deficiency. It causes metabolic changes that lead to the damage and functional impairment of organs and tissues resulting in increased morbidity and mortality. It is this form of diabetes whose prevalence is increasing at an alarming rate due to the 'obesity epidemic', as obesity is a key risk factor in the development of insulin resistance. However, the majority of individuals who have insulin resistance do not develop diabetes due to a compensatory increase in insulin secretion in response to an increase in insulin demand. This adaptive response is sustained by an increase in both β-cell function and mass. Importantly, there is increasing evidence that the Serine/Threonine kinase mammalian target of rapamycin (mTOR) plays a key role in the regulation of β-cell mass and therefore likely plays a critical role in β-cell adaptation. Therefore, the primary focus of this review is to summarize our current understanding of the role of mTOR in stimulating pancreatic β-cell mass and thus, in the prevention of type-2 diabetes.     

Fetal and animal research in Sweden: The construction of viable lives in regulatory policy debates, 1970–1980

Following demands to regulate biomedicine in the post-war period, Sweden saw several political debates about research ethics in the 1970s. Many of the debates centered on fetal research and animal experiments. At stake were questions of moral permissibility, public transparency, and scientific freedom. However, these debates did not only reveal ethical disagreement—they also contributed to constructing new boundaries between life-forms. Taking a post-Marxist approach to discursive policy analysis, we argue that the meaning of both the “human” and the “animal” in these debates was shaped by a need to manage a legitimacy crisis for medical science. By analyzing Swedish government bills, motions, parliamentary debates, and committee memorials from the 1970s, we map out how fetal and animal research were constituted as policy problems. We place particular emphasis on the problematization of fetal and animal vulnerability. By comparing the debates, we trace out how a particular vision of the ideal life defined the human-animal distinction.