世界植物园的现状与展望

世界植物园的发展史，是一部人类加深认识、进行保护和扩大利用植物的历史。随着植物园数量的增长，植物园可分为综合性、园林和观赏园艺、经济植物及种质保存等类型。当前植物瞻的任务主要为植物多样性的保护、植物资源利用、展示教育与咨询和科学研究。由于植物资源的竞争更加激烈但规范化、管理更加现代化与科学化、植物园更加开放与联合，展望植物园今后的发展，可能将在植物园学和科学植物园、专类园建设及群落建园、植物园信息管理系统、虚拟植物园与科普、植物园网络化、推动植物资源可持续利用等方面不断加强与完善。     

Outward bound: women translators and scientific travel writing, 1780–1800

SUMMARY

As the Enlightenment drew to a close, translation had gradually acquired an increasingly important role in the international circulation and transmission of scientific knowledge. Yet comparatively little attention has been paid to the translators responsible for making such accounts accessible in other languages, some of whom were women. In this article I explore how European women cast themselves as intellectually enquiring, knowledgeable and authoritative figures in their translations. Focusing specifically on the genre of scientific travel writing, I investigate the narrative strategies deployed by women translators to mark their involvement in the process of scientific knowledge-making. These strategies ranged from rhetorical near-invisibility, driven by women's modest marginalization of their own public engagement in science, to the active advertisement of themselves as intellectually curious consumers of scientific knowledge. A detailed study of Elizabeth Helme's translation of the French ornithologist François le Vaillant's Voyage dans l'intérieur de l'Afrique [Voyage into the Interior of Africa] (1790) allows me to explore how her reworking of the original text for an Anglophone reading public enabled her to engage cautiously – or sometimes more openly – with questions regarding how scientific knowledge was constructed, for whom and with which aims in mind.     

Renaissance humanism and botany

The enthusiasm of Renaissance humanists for classical learning greatly influenced the development of botany in the late fifteenth and sixteenth centuries. Humanist scholars restored the treatises of Theophrastus, Pliny, Galen and Dioscorides on botany and materia medica to general circulation and argued for their use as textbooks in Renaissance universities. Renaissance botanists' respect for classical precepts and models of the proper methods for studying plants temporarily discouraged the use of naturalistic botanical illustration, but encouraged other techniques for collecting and communicating new observations: herbaria, botanical gardens and field trips.     

Knowledge Management to Exploit Agrarian Resources as Part of Late-eighteenth-century Cultures of Innovation: Friedrich Casimir Medicus and Franz von Paula Schrank

Summary

This essay contributes to a recent strain of research that questions clear-cut dichotomies between ‘scientists’ and ‘artisans’ in the early modern period. With a focus on the exploitation of agrarian resources, it argues for the appreciation of a more complex panorama of intersecting knowledge systems spanning from botany as part of natural history, over administrational and teaching expertise, to various sorts of practical experience in agriculture. With this aim, the essay investigates the careers of two protagonists of the ‘economic enlightenment’ in Southern Germany in the late eighteenth century, Friedrich Casimir Medicus and Franz von Paula Schrank. Financed mostly by territorial powers to which they remained closely related throughout their lives, their careers were characterized by ‘scientific’ investigations as well as by engaging in higher education and extensive publication for diverse audiences. According to the argument set forth here, the panorama of the activities of these two figures can best be understood when seen in the light of early modern cultures of innovation aiming to stimulate economic growth by collecting, testing and distributing advanced technical knowledge. Against a position advocated for most recently in a monograph by Andre Wakefield on German cameralism, the final section argues for a long-term perspective on this development with regard to the emergence of technical sciences in the nineteenth and twentieth centuries as more appropriate than a focus on the ‘failure’ of such actors to turn their aims immediately into practice.     

The Challenge of Colour: Eighteenth-Century Botanists and the Hand-Colouring of Illustrations

Colourful plant images are often taken as the icon of natural history illustration. However, so far, little attention has been paid to the question of how this beautiful colouring was achieved. At a case study of the eighteenth-century Nuremberg doctor and botanist, Christoph Jacob Trew, the process of how illustrations were hand-coloured, who was involved in this work, and how the colouring was supervised and evaluated is reconstructed, mostly based on Trew's correspondence with the engraver and publisher of his books, Johann Jacob Haid in Augsburg. Furthermore, the question of standardizing colours, their uses and their recipes is discussed at two examples of the same time period: the colour charts of the Bauer brothers, arguably the most renowned botanical draughtsmen of the period, and the colour tables by the Regensburg naturalist, Jacob Christian Schaeffer. Hand-colouring botanical illustrations, it is argued, was far from a straightforward task but confronted botanists and their employees with a plethora of practical and methodological problems, to which different solutions were developed in the course of time. Analysing these problems and solutions reveals some new and interesting aspects of the practices of eighteenth-century botany and of the production of scientific illustrations in general.     

Light perception in higher plants

Photosynthetic plants depend on sunlight as their energy source. Thus, they need to detect the intensity, quality and direction of this critical environmental factor and to respond properly by optimizing their growth and development. Perception of light is accomplished by several photoreceptors including phytochromes, blue/ultraviolet (UV)-A and UV-B light photoreceptors. In recent years, genetic, molecular genetic and cell biological approaches have significantly increased our knowledge about the structure and function of the photoreceptors, and allowed the identification of several light signal transduction components. Furthermore, this research led to fruitful interaction between different disciplines, such as molecular biology and ecology. It is safe to assume that we can expect more milestones in this research field in the upcoming years.     

Causation and gravitation in George Cheyne's Newtonian natural philosophy

This paper analyzes the metaphysical system developed in Cheyne’s Philosophical Principles of Religion. Cheyne was an early proponent of Newtonianism and tackled several philosophical questions raised by Newton’s work. The most pressing of these concerned the causal origin of gravitational attraction. Cheyne rejected the occasionalist explanations offered by several of his contemporaries in favor of a model on which God delegated special causal powers to bodies. Additionally, he developed an innovative approach to divine conservation. This allowed him to argue that Newton’s findings provided evidence for God’s existence and providence without the need for continuous divine intervention in the universe.     

Reverse transendothelial cell migration in inflammation: to help or to hinder?

The endothelium provides a strong barrier separating circulating blood from tissue. It also provides a significant challenge for immune cells in the bloodstream to access potential sites of infection. To mount an effective immune response, leukocytes traverse the endothelial layer in a process known as transendothelial migration. Decades of work have allowed dissection of the mechanisms through which immune cells gain access into peripheral tissues, and subsequently to inflammatory foci. However, an often under-appreciated or potentially ignored question is whether transmigrated leukocytes can leave these inflammatory sites, and perhaps even return across the endothelium and re-enter circulation. Although evidence has existed to support “reverse” transendothelial migration for a number of years, it is only recently that mechanisms associated with this process have been described. Here we review the evidence that supports both reverse transendothelial migration and reverse interstitial migration within tissues, with particular emphasis on some of the more recent studies that finally hint at potential mechanisms. Additionally, we postulate the biological significance of retrograde migration, and whether it serves as an additional mechanism to limit pathology, or provides a basis for the dissemination of systemic inflammation.     

The Prussian Mining Official Alexander von Humboldt

From summer 1792 until spring 1797, Alexander von Humboldt was a mining official in the Franconian parts of Prussia. He visited mines, inspected smelting works, calculated budgets, wrote official reports, founded a mining school, performed technological experiments, and invented a miners’ lamp and respirator. At the same time he also participated in the Republic of Letters, corresponded with savants in all Europe, and was a member of the Leopoldine Carolinian Academy and the Berlin Gesellschaft Naturforschender Freunde. He collected minerals, made geognostic observations, performed chemical and physiological experiments, read the newest scientific journals, and prepared and published texts on mineralogy, geognosy, chemistry, botany and physiology. Humboldt did his scientific investigations alongside his administrative and technical work. This raises the question of whether there were fruitful interactions between Humboldt's technical-administrative work and (parts of) his natural inquiry. I argue that the mining official Humboldt was a late eighteenth-century figure of hybrid savant-technician. Mines and smelting works provided numerous opportunities for studies of nature. Humboldt systematically used inspection tours for mineralogical and geognostic observations. He transformed mines into chemical laboratories, and he transferred knowledge and material items from his natural inquiries in mines to academic institutions. The main objective of this paper is to illuminate the persona of savant-technician (or scientific-technological expert) along with Humboldt's mixed technological and scientific work during his term as mining official.     

A beautiful sea: P. A. M. Dirac's epistemology and ontology of the vacuum

This paper charts P.A.M. Dirac's development of his theory of the electron, and its radical picture of empty space as an almost-full plenum. Dirac's Quantum Electrodynamics famously accomplished more than the unification of special relativity and quantum mechanics. It also accounted for the ‘duplexity phenomena’ of spectral line splitting that we now attribute to electron spin. But the extra mathematical terms that allowed for spin were not alone, and this paper charts Dirac's struggle to ignore or account for them as a sea of strange, negative-energy, particles with positive ‘holes’. This work was not done in solitude, but rather in exchanges with Dirac's correspondence network. This social context for Dirac’s work contests his image as a lone genius, and documents a community wrestling with the ontological consequences of their work. Unification, consistency, causality, and community are common factors in explanations in the history of physics. This paper argues on the basis of materials in Dirac's archive that --- in addition --- mathematical beauty was an epistemological factor in the development of the electron and hole theory. In fact, if we believe that Dirac's beautiful mathematics captures something of the world, then there is both an epistemology and an ontology of mathematical beauty.     

Where explanation ends: Understanding as the place the spade turns in the social sciences

Explanations implicitly end with something that makes sense, and begin with something that does not make sense. A statistical relationship, for example, a numerical fact, does not make sense; an explanation of this relationship adds something, such as causal information, which does make sense, and provides an endpoint for the sense-making process. Does social science differ from natural science in this respect? One difference is that in the natural sciences, models are what need “understanding.” In the social sciences, matters are more complex. There are models, such as causal models, which need to be understood, but also depend on background knowledge that goes beyond the model and the correlations that make it up, which produces a regress. The background knowledge is knowledge of in-filling mechanisms, which are normally made up of elements that involve the direct understanding of the acting and believing subjects themselves. These models, and social science explanations generally, are satisfactory only when they end the regress in this kind of understanding or use direct understanding evidence to decide between alternative mechanism explanations.     

Thomas Harriot—Sir Walter Ralegh's tutor—On population

The empiricism of eighteenth-century experimental science meant that the development of scientific instruments influenced the formulation of new concepts; a two-way process for new theory also affected instrument design. This relationship between concept and instrumentation will be examined by tracing the development of electrical instruments and theory during this period. The different functions fulfilled by these devices will also be discussed. Empiricism was especially important in such a new field of research as electricity, for it gave rise to phenomena that could not have been predicted by theory alone. However, the interpretation of these phenomena, and what the natural philosopher thought he observed, were often unconsciously determined by current ideas and attitudes; the interaction between instrumentally induced phenomena and observation was more complex than was realized at the time. The shortcomings of this empirical approach will be discussed. In the case of electricity this became increasingly apparent during the latter part of the century. The many discoveries had to be placed in a unifying framework before new advances could be made. Instruments, however, continued to play an important role in scientific progress, for they made visible what was hidden in nature.     

Between two worlds: Yamanouchi Shigeo and eugenics in early twentieth-century Japan

This paper explores the eugenic through of Yamanouchi Shigeo (1876-1973), who was trained in plant cytology under the tutelage of botanist and eugenicist John Coulter (1851-1928) in the USA, and later become one of the early and important popularizers of eugenic ideas in Japan. His career demonstrates a direct link between Japanese and US eugenics. Despite his academic training and research at various internationally renowned institutions, numerous publications, and longevity, his life has received little scholarly attention. By the early twentieth century, most biologists in Japan, as in the USA, began accepting Mendelian evolutionary theory and rejecting the Lamarckian notion of inheritance of acquire characteristics. However, Yamanouchi Shigeo's eugenic view represents a paradox: he was a mendelian cytologist sympathetic to Lamarckism. Was his 'nurture'-oriented eugenic view unscientific? is that why he was largely ignored in the history of botany in Japan? This study attempts to answer these questions and to analyse the origins and distinct features of Yamanouchi's eugenic ideas by situating Yamanouchi's eugenic through historically and culturally. After examining his scientific papers, popular writings, and documents of various organizations to which he belonged, I argue that Yamanouchi's 'softer' (or less biologically deterministic) perspective may have reflected the Japanese desire to catch up with the dominant 'race' by using eugenics without accepting permanent inferior status.     

Euler’s beta integral in Pietro Mengoli’s works

Beta integrals for several non-integer values of the exponents were calculated by Leonhard Euler in 1730, when he was trying to find the general term for the factorial function by means of an algebraic expression. Nevertheless, 70 years before, Pietro Mengoli (1626–1686) had computed such integrals for natural and half-integer exponents in his Geometriae Speciosae Elementa (1659) and Circolo(1672) and displayed the results in triangular tables. In particular, his new arithmetic–algebraic method allowed him to compute the quadrature of the circle. The aim of this article is to show how Mengoli calculated the values of these integrals as well as how he analysed the relation between these values and the exponents inside the integrals. This analysis provides new insights into Mengoli’s view of his algorithmic computation of quadratures.     

Francis Galton’s regression towards mediocrity and the stability of types

A prevalent narrative locates the discovery of the statistical phenomenon of regression to the mean in the work of Francis Galton. It is claimed that after 1885, Galton came to explain the fact that offspring deviated less from the mean value of the population than their parents did as a population-level statistical phenomenon and not as the result of the processes of inheritance. Arguing against this claim, we show that Galton did not explain regression towards mediocrity statistically, and did not give up on his ideas regarding an inheritance process that caused offspring to revert to the mean. While the common narrative focuses almost exclusively on Galton’s statistics, our arguments emphasize the anthropological and biological questions that Galton addressed. Galton used regression towards mediocrity to support the claim that some biological types were more stable than others and hence were resistant to evolutionary change. This view had implications concerning both natural selection and eugenics. The statistical explanation attributed to Galton appeared later, during the biometrician-mutationist debate in the early 1900s. It was in the context of this debate and specifically by the biometricians, that the development of the statistical explanation was originally attributed to Galton.     

Self and non-self discrimination is needed for the existence rather than deletion of autoimmunity: the role of regulatory T cells in protective autoimmunity

Autoimmune T cells have been viewed for decades as an outcome of immune system malfunction, and specifically as a failure to distinguish between components of self and non-self. The need for discrimination between self and non-self as a way to avoid autoimmunity has been repeatedly debated over the years. Recent studies suggest that autoimmunity, at least in the nervous system, is the bodys defense mechanism against deviations from the normal. The ability to harness neuroprotective autoimmunity upon need is evidently allowed by naturally occurring CD4+CD25+ regulatory T cells, which are themselves controlled by brain-derived compounds. These findings challenge widely accepted concepts of the need for discrimination between self and non-self, as they suggest that while such discrimination is indeed required, it is needed not as a way to avoid an anti-self response but to ensure its proper regulation. Whereas a response to non-self can be self-limited by a decreased presence of the relevant antigen, the response to self needs a mechanism for strict control, such as that provided by the naturally occurring regulatory T cells.Received 8 June 2004; accepted 6 July 2004     

The perpetual movements of anaphase

One of the most extraordinary events in the lifetime of a cell is the coordinated separation of sister chromatids during cell division. This is truly the essence of the entire mitotic process and the reason for the most profound morphological changes in cytoskeleton and nuclear organization that a cell may ever experience. It all occurs within a very short time window known as “anaphase”, as if the cell had spent the rest of its existence getting ready for this moment in an ultimate act of survival. And there is a good reason for this: no space for mistakes. Problems in the distribution of chromosomes during cell division have been correlated with aneuploidy, a common feature observed in cancers and several birth defects, and the main cause of spontaneous abortion in humans. In this paper, we critically review the mechanisms of anaphase chromosome motion that resisted the scrutiny of more than 100 years of research, as part of a tribute to the pioneering work of Miguel Mota.     

Analytical morphodynamics. Practical applications]

The analytical morphodynamic method, based on the study of the fate of the biogic units of an organ at the level of well or poorly developed lesions, has been applied to the analysis of chronic obliterating arteriopathies of the extremities, of benign tumors of the mammary parenchyma, and of malignant hepatomas. In morbid states as different as a reactive process and a benign or malignant neoplastic process, it allowed to reconstritute the histogenesis of complex tissue changes and led to interesting prospects, in the field of general biology and pathogenesis.     

Newton’s “satis est”: A new explanatory role for laws

In this paper I argue that Newton’s stance on explanation in physics was enabled by his overall methodology and that it neither committed him to embrace action at a distance nor to set aside philosophical and metaphysical questions. Rather his methodology allowed him to embrace a non-causal, yet non-inferior, kind of explanation. I suggest that Newton holds that the theory developed in the Principia provides a genuine explanation, namely a law-based one, but that we also lack something explanatory, namely a causal account of the explanandum. Finally, I argue that examining what it takes to have law-based explanation in the face of agnosticism about the causal process makes it possible to recast the debate over action at a distance between Leibniz and Newton as empirically and methodologically motivated on both sides.