Early explorations of the southern celestial sky

In this paper the astronomical explorations of the southern celestial sky by Dutch navigators at the end of the sixteenth century are investigated. It is shown that the main motivation for this scientific enterprise stemmed from Dutch cartographic tradition and interests, represented first and foremost by Petrus Plancius and the competing globemakers Hondius and Blaeu. It is shown, too, that at the time actually two surveys were carried out. We have investigated the results of the two surveys by analysing the data presented on celestial globes by Hondius and Blaeu, and in the star catalogue published by De Houtman in 1603. It appears that only after the first survey was it recognized that the stars of the well-known Southern Cross constellation could be matched with stars already recorded by Ptolemy.     

Writing tea’s empire

The Almagest of Ptolemy (mid-second century ad) contains eleven dated reports of observations of the positions of planets made during the third century bc in Babylon and Hellenistic Egypt. The present paper investigates the character, purpose, and conventions of the observational programmes from which these reports derive, the channels of their transmission to Ptolemy's time, and the fidelity of Ptolemy's presentation of them. Like the Babylonian observational programme, about which we have considerable knowledge through cuneiform documents, the Greco-Egyptian ones were not directed towards the deduction of mathematical models of celestial motion but appear to have investigated patterns, correlations, and periodicities of phenomena. Ptolemy's immediate sources most likely were not the original series of observational records, but treatises by various astronomers of the intervening four centuries, including Hipparchus. While Ptolemy does not appear to have tampered with the wording of the reports, he faced difficulties and uncertainties in interpreting them; critically, he lacked sufficiently detailed information about the ancient calendars to be able to convert the reported dates accurately into his own chronological framework based on the Egyptian calendar.     

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold

Sea anemone venoms have long been recognized as a rich source of peptides with interesting pharmacological and structural properties, but they still contain many uncharacterized bioactive compounds. Here we report the discovery, three-dimensional structure, activity, tissue localization, and putative function of a novel sea anemone peptide toxin that constitutes a new, sixth type of voltage-gated potassium channel (K_V) toxin from sea anemones. Comprised of just 17 residues, κ-actitoxin-Ate1a (Ate1a) is the shortest sea anemone toxin reported to date, and it adopts a novel three-dimensional structure that we have named the Proline-Hinged Asymmetric β-hairpin (PHAB) fold. Mass spectrometry imaging and bioassays suggest that Ate1a serves a primarily predatory function by immobilising prey, and we show this is achieved through inhibition of Shaker-type K_V channels. Ate1a is encoded as a multi-domain precursor protein that yields multiple identical mature peptides, which likely evolved by multiple domain duplication events in an actinioidean ancestor. Despite this ancient evolutionary history, the PHAB-encoding gene family exhibits remarkable sequence conservation in the mature peptide domains. We demonstrate that this conservation is likely due to intra-gene concerted evolution, which has to our knowledge not previously been reported for toxin genes. We propose that the concerted evolution of toxin domains provides a hitherto unrecognised way to circumvent the effects of the costly evolutionary arms race considered to drive toxin gene evolution by ensuring efficient secretion of ecologically important predatory toxins.     

The Newton letters (Vols. I and II)

The metaphysical commitment to the circle as the essential element in the analysis of celestial motion has long been recognized as the hallmark of classical astronomy. What has not always been clear, however, is that the circle continued to serve Kepler as a central element in his astronomy after the discovery of the elliptical orbit of Mars. Moreover, the circle also functioned for Kepler in geometry to select the basic polygons, in music to select the basic harmonies, and in astrology to select the basic aspects. His basic set of polygons consisted of those figures that could be constructed using only a compass and a rule; the set of fundamental harmonies consisted of the consonances of the just intonation; and the traditional set of astrological aspects were enlarged by Kepler to include three new aspects in order to make the astrological set consistent with geometry and music. And as the circle served to unify these three areas, so also did it serve to supply the fundamental answers to astronomical problems well after the discovery of his new astronomy—a topic to be discussed in Part II of this paper.     

Perception and description of New World non-human primates in the travel literature of the fifteenth and sixteenth centuries: a critical review

The current work presents the results of a review of most of the European diaries and travel chronicles containing reports of New World non-human primates dating from the discovery of America in 1492 until the end of the sixteenth century. We report the integral texts translated into English of these literary sources, giving a critical interpretation from a historical and scientific point of view. We note the ways these primates were perceived and described, with attention to the most important characteristics that were highlighted by the first explorers. Ethnotaxonomy and vernacular names used to designate non-human primates are also provided. This new body of knowledge, based largely on empirical reports full of details and first-hand observations, emerged as the first nucleus in the natural history of Neotropical Primates.     

A Study of Babylonian Observations of Planets Near Normal Stars

The present paper is an attempt to describe the observational practices behind a large and homogeneous body of Babylonian observation reports involving planets and certain bright stars near the ecliptic (Normal Stars). The reports in question are the only precise positional observations of planets in the Babylonian texts, and while we do not know their original purpose, they may have had a part in the development of predictive models for planetary phenomena in the second half of the first millennium B.C. The paper is organized according to the following topics: (I) Sections 1–3 review the format of the observations and the texts in which they are found; (II) Sections 4–6 discuss the composition of the Normal Star list; (III) Sections 7–8 concern the orientation of the reported celestial directions from star to planet; (IV) Sect. 9 concerns the relationship between the reported distances and the actual angular distances between planet and star; and (V) Sect. 10 discusses the reports of planetary stations, which are the most common reports giving precise locations of planets when they are not near their closest approach to stars, and draws some brief general conclusions about the utility of the Babylonian observations for estimating planetary longitudes and calibrating models in antiquity.I wish to thank Lis Brack-Bernsen, John Britton, Peter Huber, Hermann Hunger, Teije de Jong, Norbert Roughton, John Steele, and Noel Swerdlow for comments on drafts of the paper, for access to work before publication, and for help in various forms.     

On Kepler's awareness of the problem of experimental error

This paper is an account of Kepler's explicit awareness of the problem of experimental error. As a study of the Astronomia nova shows, Kepler exploited his awareness of the occurrences of experimental errors to guide him to the right conclusion. Errors were thus employed, so to speak, perhaps for the first time, to bring about a major physical discovery: Kepler's laws of planetary motion. ‘Know then’, to use Kepler's own words, ‘that errors show us the way to truth.’ With a survey of Kepler's revolutionary contribution to optics, the paper demonstrates that Kepler's awareness of the problem of experimental error extended beyond discrepancies between calculations and observations to types of error which pertain to observations and instruments. It emerges that Kepler's belief in the unity of knowledge and physical realism, facilitated—indeed created—the right philosophical posture for comprehending the problem of error in an entirely novel way.     

Experiential and cosmopolitan knowledge: The transcontinental field practices of the U.S. Bureau of Biological Survey

Before many of the global environmental knowledge producing networks and technologies emerged later in the twentieth century, another spatially extended form of field science was implemented at a continental scale by the U.S. Bureau of Biological Survey, revealing similar tensions and dynamics. Specimens and observations from across continental spaces were integrated through railroad-based transportation and communications networks in order to map distributions of birds and mammals and delineate “life zones” stretching across the continent. At the same time that field zoologists of the Biological Survey produced this cosmopolitan scientific knowledge, they also developed an intimate, experiential knowledge of many of the places where they traveled. By following the travels of Biological Survey field parties, especially the agency's long-time chief field naturalist Vernon Bailey, during the late nineteenth and early twentieth centuries when the railroad was dominant, this paper traces the interconnections between the two ways of knowing in the Biological Survey's practice. However, the integration of these different forms of knowledge was ultimately partial and incomplete, as seen through the Survey's daily practices such as food consumption, the seasonality of survey field practice, and limitations on what types of knowledge were incorporated from lay network collaborators and field assistants.     

Ausbau und gegenwärtiger Stand der astronomischen Theorie der erdgeschichtlichen Klimate

Summary After numerous attempts to explain the phenomenon of the glacial periods, undertaken since 1842, had failed, it became evident that the solution of this problem must be sought in a wider field of science. When finally use was made of the requisite items of knowledge concerning celestial mechanics, spheric astronomy, and cosmic rays, the secular variations of the terrestrial radiation could be calculated exactly out of their interrelations, which gave the key to the solution. How this came about is described in detail in the article.     

A structural view of nuclear hormone receptor: endocrine disruptor interactions

Endocrine-disrupting chemicals (EDCs) represent a broad class of exogenous substances that cause adverse effects in the endocrine system by interfering with hormone biosynthesis, metabolism, or action. The molecular mechanisms of EDCs involve different pathways including interactions with nuclear hormone receptors (NHRs) which are primary targets of a large variety of environmental contaminants. Here, based on the crystal structures currently available in the Protein Data Bank, we review recent studies showing the many ways in which EDCs interact with NHRs and impact their signaling pathways. Like the estrogenic chemical diethylstilbestrol, some EDCs mimic the natural hormones through conserved protein–ligand contacts, while others, such as organotins, employ radically different binding mechanisms. Such structure-based knowledge, in addition to providing a better understanding of EDC activities, can be used to predict the endocrine-disrupting potential of environmental pollutants and may have applications in drug discovery.     

Celestial chaos: The new logics of theory-testing in orbital dynamics

I explore how the nature, scope, and limits of the knowledge obtained in orbital dynamics has changed in recent years. Innovations in the design of spacecraft trajectories, as well as in astronomy, have led to new logics of theory-testing—that is, new research methodologies—in orbital dynamics. These methodologies—which combine resonance overlap theories, numerical experiments, and the implementation of space missions—were developed in response to the discovery of chaotic dynamical systems in our solar system. In the past few decades, they have replaced the methodology that dominated orbital research in the centuries following Newton's Principia. As a result, the kind of knowledge achieved by orbital research has changed: we can know how orbiting bodies in chaotic systems behave, but only over sufficiently short time scales; and we can reliably measure those temporal limitations, using Lyapunov time.     

Autotaxin

Autotaxin is a protein of approximately 900 amino acids discovered in the early 1990s. Over the past 15 years, a strong association between cancer cells and autotaxin production has been observed. Recent publications indicate that autotaxin and the capacity of cancer to metastasise are intimately linked. The discovery of new molecular targets in pharmacology is a mixture of pure luck, hard work and industrial strategy. Despite a crucial and desperate need for new therapeutic tools, many targets are approached in oncology, but only a few are validated and end up at the patient bed. Outside the busy domain of kinases, few targets have been discovered that can be useful in treating cancer, particularly metastatic processes. The fortuitous relationship between autotaxin and lysophosphatidic acid renders the results of observations made in the diabetes/obesity context considerably important. The literature provides observations that may aid in redesigning experiments to validate autotaxin as a potential oncology target.     

Knut Lundmark,Meteors and an Early Swedish Crowdsourcing Experiment

Mid twentieth century meteor astronomy demanded the long-term compilation of observations made by numerous individuals over an extensive geographical area. Such a massive undertaking obviously required the participation of more than just professional astronomers, who often sought to expand their ranks through the use of amateurs that had a basic grasp of astronomy as well as the night sky, and were thus capable of generating first-rate astronomical reports.

When, in the 1920s, renowned Swedish astronomer Knut Lundmark turned his attention to meteor astronomy, he was unable to rely even upon this solution. In contrast to many other countries at the time, Sweden lacked an organized amateur astronomy and thus contained only a handful of competent amateurs. Given this situation, Lundmark had to develop ways of engaging the general public in assisting his efforts. To his advantage, he was already a well-established public figure who had published numerous popular science articles and held talks from time to time on the radio. During the 1930s, this prominence greatly facilitated his launching of a crowdsourcing initiative for the gathering of meteor observations.

This paper consists of a detailed discussion concerning the means by which Lundmark's initiative disseminated astronomical knowledge to the general public and encouraged a response that might directly contribute to the advancement of science. More precisely, the article explores the manner in which he approached the Swedish public, the degree to which that public responded and the extent to which his efforts were successful. The primary aim of this exercise is to show that the apparently recent Internet phenomenon of ‘crowdsourcing’, especially as it relates to scientific research, actually has a pre-Internet history that is worth studying. Apart from the fact that this history is interesting in its own right, knowing it can provide us with a fresh vantage point from which to better comprehend and appreciate the success of present-day crowdsourcing projects.     

Magnetic orientation and celestial cues in migratory orientation

Summary Young birds on their first migration possess innate information on the direction of their migration route. It is present in two forms, using celestial rotation and the geomagnetic field as references. These two systems, together with information provided by factors associated with sunset, interact in a complex way to establish the migratory direction. During ontogeny, celestial rotation appears to be dominant; during migration, however, celestial cues appear to be controlled by the magnetic field. The factors associated with sunset — the view of the setting sun, the characteristic pattern of polarized light — are important secondary cues which seem to derive their directional significance from the magnetic field. Their role appears to be more variable, with possible species-specific differences. During spring migration and later autumn migrations, flying in the migratory direction is complemented by navigational processes which enable the birds to return to a specific home site known from previous stays.     

The heuristic role of mathematics in the initial development of superconductivity theory

During the first twenty-four years after the discovery of superconductivity many attempts to derive an adequate theory failed, mainly because the problem was not formulated quite correctly. In this paper we investigate certain questions related to the heuristic role of mathematics in the appropriate formulation of the problem that had to be solved and the development of a theory which was hindered by theoretical superstitions.     

Biochemistry of the non-mevalonate isoprenoid pathway

The non-mevalonate pathway of isoprenoid (terpenoid) biosynthesis is essential in many eubacteria including the major human pathogen, Mycobacterium tuberculosis, in apicomplexan protozoa including the Plasmodium spp. causing malaria, and in the plastids of plants. The metabolic route is absent in humans and is therefore qualified as a promising target for new anti-infective drugs and herbicides. Biochemical and structural knowledge about all enzymes involved in the pathway established the basis for discovery and development of inhibitors by high-throughput screening of compound libraries and/or structure-based rational design.     

Visual spatial memory in desert ants,Cataglyphis bicolor (Hymenoptera: Formicidae)

Summary For navigation, desert ants apply piloting and dead-reckoning strategies based on terrestrial and celestial visual cues, respectively. Visual spatial memories, rather than general concepts derived from landmark constellations, are most probably used to define points on earth by nearby landmarks. The visual field of a specialized dorsal part of the ant's retina is mapped on to the celestial sphere to consider the possibility that similar mechanisms are used to define directions on earth by exploiting skylight patterns present at infinity.Supported by the Hescheler Foundation (Zurich) and the Swiss National Science Foundation grants Nos 3.529-0.75 and 3.313-0.78.     

Retroelements and their impact on genome evolution and functioning

Retroelements comprise a considerable fraction of eukaryotic genomes. Since their initial discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes of almost all organisms. First considered as a “junk DNA” or genomic parasites, they were shown to influence genome functioning and to promote genetic innovations. For this reason, they were suggested as an important creative force in the genome evolution and adaptation of an organism to altered environmental conditions. In this review, we summarize the up-to-date knowledge of different ways of retroelement involvement in structural and functional evolution of genes and genomes, as well as the mechanisms generated by cells to control their retrotransposition.