The scientific dimensions of social knowledge and their distant echoes in 20th-century American philosophy of science

The widespread impression that recent philosophy of science has pioneered exploration of the “social dimensions of scientific knowledge” is shown to be in error, partly due to a lack of appreciation of historical precedent, and partly due to a misunderstanding of how the social sciences and philosophy have been intertwined over the last century. This paper argues that the referents of “democracy” are an important key in the American context, and that orthodoxies in the philosophy of science tend to be molded by the actual regimes of science organization within which they are embedded. These theses are illustrated by consideration of three representative philosophers of science: John Dewey, Hans Reichenbach, and Philip Kitcher.     

The sugar industry, political authorities, and scientific institutions in the regulation of saccharin: Valencia (1888-1939)

In the late-nineteenth century food production and trade were greatly transformed. Changes in the food chain gave rise to new problems connected with food safety and food quality, which caused new controls to be introduced throughout Europe. In this paper I will contribute to ongoing debates by focusing on the regulation of saccharin in an agrarian city in the south of Europe, Valencia. The laboratory-made sweetener was introduced into the food market at the turn of the century, becoming highly controversial shortly afterwards. Several local groups of players got involved in this dispute. The sugar industry was not only an important stakeholder in the passing of some specific laws that were to constrain the use of saccharin, but also the main driver of regulation, primarily in periods when saccharin could become a serious competitor and reduce the sector's profit. Furthermore, the combined work of the sugar industry and the municipal laboratories was essential for the implementation of regulations. It was in such municipal laboratories that scientists played a main role in regulation. My paper will address the commercial disputes linked to the use of saccharin and the limited role of science and scientists in its control.     

Models, scientific realism, the intelligibility of nature, and their cultural significance

In this article, I will view realist and non-realist accounts of scientific models within the larger context of the cultural significance of scientific knowledge. I begin by looking at the historical context and origins of the problem of scientific realism, and claim that it is originally of cultural and not only philosophical, significance. The cultural significance of debates on the epistemological status of scientific models is then related to the question of ‘intelligibility’ and how science, through models, can give us knowledge of the world by presenting us with an ‘intelligible account/picture of the world’, thus fulfilling its cultural-epistemic role. Realists typically assert that science can perform this role, while non-realists deny this. The various strategies adopted by realists and non-realists in making good their respective claims, is then traced to their cultural motivations. Finally I discuss the cultural implications of adopting realist or non-realist views of models through a discussion of the views of Rorty, Gellner, Van Fraassen and Clifford Hooker on the cultural significance of scientific knowledge.     

The birth of modern science: culture, mentalities and scientific innovation

In a recent paper, Luc Faucher and others have argued for the existence of deep cultural differences between ‘Chinese’ and ‘East Asian’ ways of understanding the world and those of ‘ancient Greeks’ and ‘Americans’. Rejecting Alison Gopnik’s speculation that the development of modern science was driven by the increasing availability of leisure and information in the late Renaissance, they claim instead—following Richard Nisbett—that the birth of mathematical science was aided by ‘Greek’, or ‘Western’, cultural norms that encouraged analytic, abstract and rational theorizing. They argue that ‘Chinese’ and ‘East Asian’ cultural norms favoured, by contrast, holistic, concrete and dialectical modes of thinking. After clarifying some of the things that can be meant by ‘culture’ and ‘mentality’, the present paper shows that Faucher and his colleagues make a number of appeals—to the authority of comparative studies and history of science, to the psychological studies of Nisbett and his colleagues, and to a hidden assumption of strong cultural continuity in the West. It is argued that every one of these appeals is misguided, and, further, that the psychological findings of Nisbett and others have little bearing on questions concerning the origins of modern science. Finally, it is suggested that the ‘Needham question’ about why the birth of modern science occurred in Europe rather than anywhere else is itself multiply confused to the extent that it may express no significant query.     

Jewish theologies of space in the scientific revolution: Henry More,Joseph Raphson,Isaac Newton and their predecessors

Theological speculations on God's relation to place and space were introduced into the Jewish tradition by the early rabbis, initially in response to the previous appearance of words like māqôm (place) in Biblical literature. In the Middle Ages, Jewish philosophers modified these rabbinical ideas in the context of Aristotelian, Neoplatonic, and anti-Aristotelian currents within Jewish thought. One development in medieval Jewish thought of special interest for the development of ideas of space was the rise of Cabala, which Christian thinkers of the Renaissance and early modern periods saw as a sacred and primeval deposit of wisdom akin to prisca theologia. Both Henry More and, under More's influence, Joseph Raphson made use of Cabalist ideas in developing their own theologies of space. Isaac Newton was aware of these Jewish ideas but for the most part repudiated them, while making some use of māqôm as an expression of God's omnipresence.     

The accessory gland proteins in maleDrosophila: structural,reproductive, and evolutionary aspects

Recent results from biochemical and molecular genetic studies of the accessory gland proteins in maleDrosophila are reviewed. The most prominent feature is the species-specific variability. However, the analysis of the sex peptide inD. melanogaster shows that there is a strong homology in the molecular structure to the closely related sibling species, and that divergence increases with increasing phylogenetic distance. For this reason the sex peptide, after being transferred to the female genital tract during copulation, reduces receptivity and increases oviposition only in virgin females belonging to the same species group and subgroup. Even though studies were hitherto limited to a small number of the secretory components, it is evident that the accessory gland proteins play a key role in reproductive success of the fruit fly by changing female sexual behavior, supporting sperm transfer, storage and displacement. Thus, genes encoding the accessory gland proteins are apparently under strong evolutionary selection.     

Unified science as political philosophy: positivism, pluralism and liberalism

Logical positivism is widely associated with an illiberal technocratic view of politics. This view is a caricature. Some members of the left Vienna circle were explicit in their criticism of this conception of politics. In particular, Neurath’s work attempted to link the internal epistemological pluralism and tolerance of logical empiricism with political pluralism and the rejection of a technocratic politics. This paper examines the role that unified science played in Neurath’s defence of political and social pluralism. Neurath’s project of unified science addressed problems that lie at the centre of recent debates around liberalism concerning the possibility of social co-operation in conditions of pluralism. His response is distinctive in calling upon an empiricist tradition that differs from Kantian proceduralist approaches that have predominated in recent liberalism. While Neurath’s position has problems, it deserves reconsideration, especially in so far as it questions the Kantian assumption that a thin language of abstract rights provides the best basis for the cosmopolital lingua franca required by conditions of social pluralism. An investigation of the role that unified science plays in Neurath’s politics also gives reasons for revising common misconceptions about the nature of the unity of science programme itself.     

The diffusion of scientific innovations: A role typology

How do scientific innovations spread within and across scientific communities? In this paper, we propose a general account of the diffusion of scientific innovations. This account acknowledges that novel ideas must be elaborated on and conceptually translated before they can be adopted and applied to field-specific problems. We motivate our account by examining an exemplary case of knowledge diffusion, namely, the early spread of theories of rational decision-making. These theories were grounded in a set of novel mathematical tools and concepts that originated in John von Neumann and Oskar Morgenstern's Theory of Games and Economic Behavior (1944/1947) and subsequently spread widely across the social and behavioral sciences. Introducing a network-based diffusion measure, we trace the spread of those tools and concepts into distinct research areas. We furthermore present an analytically tractable typology for classifying publications according to their roles in the diffusion process. The proposed framework allows for a systematic examination of the conditions under which scientific innovations spread within and across preexisting and newly emerging scientific communities.     

Crustacean neuropeptides: Structures,functions and comparative aspects

In this article, an attempt is made to review the presently known, completely identified crustacean neuropeptides with regard to structure, function and distribution. Probably the most important progress has been made in the elucidation of a novel family of large peptides from the X-organ-sinus gland system which includes crustacean hyperglycemic hormone (CHH), putative molt-inhibiting hormone (MIH) and vitellogenesis (=gonad)-inhibiting hormone (VIH). These peptides have so far only been found in crustaceans. Renewed interest in the neurohemal pericardial organs has led to the identification of a number of cardioactive/myotropic neuropeptides, some of them. unique to crustaceans. Important contributions have been made by immunocytochemical mapping of peptidergic neurons in the nervous system, which has provided evidence for a multiple role of several neuropeptides as neurohormones on the one hand and as local transmitters or modulators on the other. This has been corroborated by physiological studies. The long-known chromatophore-regulating hormones, red pigment concentrating hormone (RPCH) and pigment-dispending hormone (PDH), have been placed in a broader perspective by the demonstration of an additional role as local neuromodulators. The scope of crustacean neuropeptide research has thus been broadened considerably during the last years.     

Molecular aspects of cyclophilins mediating therapeutic actions of their ligands

Cyclosporine A (CsA) is an immunosuppressive cyclic peptide that binds with a high affinity to 18 kDa human cyclophilin-A (hCyPA). CsA and its several natural derivatives have some pharmacological potential in treatment of diverse immune disorders. More than 20 paralogues of CyPA are expressed in the human body while expression levels and functions of numerous ORFs encoding cyclophilin-like sequences remain unknown. Certain derivatives of CsA devoid of immunosuppressive activity may have some potential in treatments of Alzheimer diseases, Hepatitis C and HIV infections, amyotrophic lateral sclerosis, congenital muscular dystrophy, asthma and various parasitic infections. Here, we discuss structural and functional aspects of the human cyclophilins and their interaction with various intra-cellular targets that can be under the control of CsA or its complexes with diverse cyclophilins that are selectively expressed in different cellular compartments. Some molecular aspects of the cyclophilins expressed in parasites invading humans and causing diseases were also analyzed.     

Feyerabend on politics,education, and scientific culture

The purpose of this paper is to offer a sympathetic reconstruction of the political thought of Paul Feyerabend. Using a critical discussion of the idea of the ‘free society’ it is suggested that his political thought is best understood in terms of three thematic concerns—liberation, hegemony, and the authority of science—and that the political significance of those claims become clear when they are considered in the context of his educational views. It emerges that Feyerabend is best understood as calling for the grounding of cognitive and cultural authorities—like the sciences—in informed deliberation, rather than the uncritical embrace of prevailing convictions. It therefore emerges that a free society is best understood as one of epistemically responsible citizenship rather than epistemically anarchistic relativism of the ‘anything goes’ sort—a striking anticipation of current debates about philosophy of science in society.     

Crustacean neuropeptides: structures, functions and comparative aspects.

In this article, an attempt is made to review the presently known, completely identified crustacean neuropeptides with regard to structure, function and distribution. Probably the most important progress has been made in the elucidation of a novel family of large peptides from the X-organ-sinus gland system which includes crustacean hyperglycemic hormone (CHH), putative molt-inhibiting hormone (MIH) and vitellogenesis (= gonad)-inhibiting hormone (VIH). These peptides have so far only been found in crustaceans. Renewed interest in the neurohemal pericardial organs has led to the identification of a number of cardioactive/myotropic neuropeptides, some of them unique to crustaceans. Important contributions have been made by immunocytochemical mapping of peptidergic neurons in the nervous system, which has provided evidence for a multiple role of several neuropeptides as neurohormones on the one hand and as local transmitters or modulators on the other. This has been corroborated by physiological studies. The long-known chromatophore-regulating hormones, red pigment concentrating hormone (RPCH) and pigment-dispending hormone (PDH), have been placed in a broader perspective by the demonstration of an additional role as local neuromodulators. The scope of crustacean neuropeptide research has thus been broadened considerably during the last years.