测量和控制生物大分子--物理学和生物学交叉的一个热点

本文讨论了测量和控制生物大分子的技术,介绍了扫描探针显微镜、扫描近场光学显微镜和光镊等以及它们的应用。     

Creativity,conservativeness & the social epistemology of science

The special issue Creativity, Conservatism & the Social Epistemology of Science collects six papers which, in different ways, tackle 'promotion questions' concerning scientific communities: which features shape those communities, and which might be changed to promote the kinds of epistemic features we desire. In this introduction, I connect these discussions with more traditional debate in the philosophy of science and reflect upon the notions of creativity which underwrite the papers.     

Existential risk,creativity & well-adapted science

Existential risks, particularly those arising from emerging technologies, are a complex, obstinate challenge for scientific study. This should motivate studying how the relevant scientific communities might be made more amenable to studying such risks. I offer an account of scientific creativity suitable for thinking about scientific communities, and provide reasons for thinking contemporary science doesn't incentivise creativity in this specified sense. I'll argue that a successful science of existential risk will be creative in my sense. So, if we want to make progress on those questions we should consider how to shift scientific incentives to encourage creativity. The analysis also has lessons for philosophical approaches to understanding the social structure of science. I introduce the notion of a ‘well-adapted’ science: one in which the incentive structure is tailored to the epistemic situation at hand.     

Moral trust & scientific collaboration

Modern scientific knowledge is increasingly collaborative. Much analysis in social epistemology models scientists as self-interested agents motivated by external inducements and sanctions. However, less research exists on the epistemic import of scientists’ moral concern for their colleagues. I argue that scientists’ trust in their colleagues’ moral motivations is a key component of the rationality of collaboration. On the prevailing account, trust is a matter of mere reliance on the self-interest of one’s colleagues. That is, scientists merely rely on external compulsion to motivate self-interested colleagues to be trustworthy collaborators. I show that this self-interest account has significant limitations. First, it cannot fully account for trust by relatively powerless scientists. Second, reliance on self-interest can be self-defeating. For each limitation, I show that moral trust can bridge the gap—when members of the scientific community cannot rely on the self-interest of their colleagues, they rationally place trust in the moral motivations of their colleagues. Case studies of mid-twentieth-century industrial laboratories and exploitation of junior scientists show that such moral trust justifies collaboration when mere reliance on the self-interest of colleagues would be irrational. Thus, this paper provides a more complete and realistic account of the rationality of scientific collaboration.     

‘Physics and fashion’: John Tyndall and his audiences in mid-Victorian Britain

This paper explores how the physicist John Tyndall transformed himself from humble surveyor and schoolmaster into an internationally applauded icon of science. Beginning with his appointment as Professor of Natural Philosophy at the Royal Institution in 1853, I show how Tyndall’s worries about his social class and Irish origins, his painstaking attention to his lecturing performance and skilled use of the material and architectural resources of the Royal Institution were vital to his eventual success as a popular expositor and ambassador for science. Secondly I explore the implications of Tyndall’s ‘popularity’ with respect to debates over the meaning and value of scientific ‘popularisation’. In support of recent work challenging diffusionist models of science communication, I show how Tyndall’s interactions with his audiences illustrate the symbiotic relationship between producer and consumer of ‘popular’ science. By examining the views of Tyndall’s critics—notably the ‘North British’ group of physicists—and his defenders and rivals in the domain of popular scientific lecturing, I show that disputes over Tyndall’s authority reflected anxieties about what constituted popular science and the transient boundaries between instruction and entertainment. The term ‘popularisation’ enjoyed many different uses in these debates, not least of all as a rheorical device with which to either exalt or destroy a scientist’s credibility.     

线粒体学与生物医学新前沿

近来大量研究证明,线粒体除了合成ATP能量之外还有多种极为重要新的细胞功能,包括生成活性氧,调节氧化还原电势和信号转导,调控基因表达和细胞凋亡等,并在生物的生长、发育、衰老、疾病、死亡以及生物进化等方面都有重要意义,成为当前生命科学和分子医学中一个新生长点和前沿。     

Challenging Expertise: Paul Feyerabend vs. Harry Collins & Robert Evans on democracy,public participation and scientific authority: Paul Feyerabend vs. Harry Collins & Robert Evans on scientific authority and public participation

This paper compares Feyerabend's arguments in Science in a Free Society to the controversial theory of expertise proposed by Harry Collins and Robert Evans as a Third Wave of Science Studies. Is the legitimacy of democratic decisions threatened by the unquestioned authority of scientific advice? Or does, on the contrary, science need protection from too much democratic participation in technical decisions? Where Feyerabend's political relativism envisions democratic society as inherently pluralist and demands equal contribution of all traditions and worldviews to public decision-making, Collins and Evans hold a conception of elective modernism, defending the reality and value of technical expertise and arguing that science deserves a privileged status in modern democracies, because scientific values are also democratic values. I will argue that Feyerabend's political relativism provides a valuable framework for the evaluation of Collins' and Evans' theory of expertise. By constructing a dialog between Feyerabend and this more recent approach in Science and Technology Studies, the aim of this article is not only to show where the two positions differ and in what way they might be reconciled, but also how Feyerabend's philosophy provides substantial input to contemporary debate.