γ-Glutamyltranspeptidases: sequence, structure, biochemical properties, and biotechnological applications

γ-Glutamyltranspeptidases (γ-GTs) are ubiquitous enzymes that catalyze the hydrolysis of γ-glutamyl bonds in glutathione and glutamine and the transfer of the released γ-glutamyl group to amino acids or short peptides. These enzymes are involved in glutathione metabolism and play critical roles in antioxidant defense, detoxification, and inflammation processes. Moreover, γ-GTs have been recently found to be involved in many physiological disorders, such as Parkinson's disease and diabetes. In this review, the main biochemical and structural properties of γ-GTs isolated from different sources, as well as their conformational stability and mechanism of catalysis, are described and examined with the aim of contributing to the discussion on their structure-function relationships. Possible applications of γ-glutamyltranspeptidases in different fields of biotechnology and medicine are also discussed.     

河海大学获准创办英文期刊Water Science and Engineering

国家新闻出版总署已正式批复同意河海大学创办英文期刊Water Science and Engineering。该刊为季刊，面向国内外公开发行，国内统一连续出版物号为CN32—1785/TV。Water Science and Engineering的办刊宗旨是：以党和国家的方针政策为指导，弘扬科学精神；探索水科学规律，创新水工程技术；反映水科学研究领域的最新成果，交流水工程建设的新技术和新经验；促进水资源的可持续利用；发扬学术民主，促进国际交流，为我国的经济建设、社会发展服务。     

United Kingdom: Extracts from the annual report for 1987–88 of the Science and Engineering Research Council

Science Policy News

United Kingdom: Extracts from the annual report for 1987–88 of the Science and Engineering Research Council     

《中国科学》和Science in China征稿简则

1.《中国科学》和Science in China是中国科学院和国家自然科学基金委员会共同主办、中国科学杂志社出版的自然科学综合性学术刊物.主要刊载自然科学各学科基础研究和应用研究方面具有创新性的、高水平的、有重要意义的研究论文,读者对象为国内外科技工作者。 2.根据学科,《中国科学》(中文版)分为A～E,G辑,Science in China(英文版)分为A～G辑出版.A辑(双月刊)为数学;B辑(双月刊)为化学;C辑(双月刊)为生命科学,包括生物学、农学和医学;D辑(月刊)     

《中国科学》和Science in China征稿简则

1.《中国科学》和Science in China是中国科学院和国家自然科学基金委员会共同主办、中国科学 杂志社出版的自然科学综合性学术刊物.主要刊载自然科学各学科基础研究和应用研究方面具有创新 性的、高水平的、有重要意义的研究论文,读者对象为国内外科技工作者.     

Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

The accumulation of aggregates of amyloidogenic peptides is associated with numerous human diseases. One well studied example is the association between deposition of amyloid beta (Abeta) and Alzheimer's disease. Insulin degrading enzyme and neprilysin are involved in the clearance of Abeta, and presequence peptidase is suggested to play a role in the degradation of mitochondrial Abeta. Recent structural analyses reveal that these three peptidases contain a catalytic chamber (crypt) that selectively encapsulates and cleaves amyloidogenic peptides, hence the name cryptidase. The substrate selectivity of these cryptidases is determined by the size and charge distribution of their crypt as well as the conformational flexibility of substrates. The interaction of Abeta with the catalytic core of these cryptidases is controlled by conformational changes that make the catalytic chambers accessible for Abeta binding. These new structural and biochemical insights into cryptidases provide potential therapeutic strategies for the control of Abeta clearance.     

远程通讯地学处理:遥感,地理信息系统,全球定位系统和远程通讯的集成

在过去的一段时间里,许多技术在各自的领域范围内得到了迅猛的发展。本文中我们致力于讨论这些技术的一体化。我们的目的在于展示一种行之有效的一体化方法,用此法处理环境问题时,综合利用所有工具和技术将比彼此分离的使用它们更有效。本文主要基于近期在遥感国际期刊(International Journal of Remote Sensing)(Xue et a1．2002)发表的一篇论文,以及一些在该论文发表后的由中国科学院遥感应用研究所的薛勇博士领导的研究小组在研究这一课题产生的其他想法。     

Science China Technological Sciences 2023年66卷第12期中文摘要

<正>电催化材料的再功能化设计思考张丹彤,彭超,薛冬峰电催化材料是新能源经济发展中的关键瓶颈.拓扑材料、磁性材料和稀土材料是电催化领域的新兴材料,已经被广泛应用于氮气还原、二氧化碳还原和水分解等领域.拓扑材料具有特殊的能带结构和几何结构,表界面差异性电荷输运结构也可以衍生出拓扑绝缘体、拓扑超导体和狄拉克金属等材料.磁性材料具有特殊的电子自旋劈裂式构型,不同自旋强度对中间体平衡吸附能力产生不同影响,且在外加交变电场、热场和磁场下,催化性能表现出明显差异.稀土材料具有独特的f电子巡游特性、宽泛的原子半径和独特的f轨道构型,通常在氧还原反应中具有明显优势.这些新材料在电催化领域的再功能化有望成为下一代新兴能源材料的引领者.