共查询到20条相似文献,搜索用时 15 毫秒
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Induction of mitochondrial DNA synthesis by polyoma virus 总被引:3,自引:0,他引:3
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L Mallucci 《Nature》1969,223(5206):630-632
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Abortive transformation by the Tsa mutant of polyoma virus 总被引:11,自引:0,他引:11
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Reversion of properties in cells transformed by polyoma virus 总被引:14,自引:0,他引:14
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Transformation of polyploid hamster cells by polyoma virus 总被引:2,自引:0,他引:2
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Infection of rabbits with human immunodeficiency virus 总被引:13,自引:0,他引:13
An important requirement for the development of a vaccine against the human immunodeficiency virus (HIV-1), the causative agent of AIDS, is a readily available animal model that would allow possible immunogens to be evaluated. The only species to have been infected with HIV-1 so far is the chimpanzee. However, the scarcity of this animal and its designation as an endangered species place severe restrictions on its use as an animal model. Attempts to infect mice, rats, hamsters, guinea-pigs, musk shrews, and rabbits with HIV-1 or infected cells have all been unsuccessful. We now report that the intraperitoneal inoculation of rabbits with HIV-1 or chronically infected H9 cells consistently induces a persistent infection. 相似文献
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Polyoma middle-T antigen is required for tumorigenesis in animals and for viral transformation of a variety of cells in culture (reviewed in ref. 1). Middle-T associates with and thereby activates p60c-src, a cellular tyrosine kinase homologous to the oncogene product of Rous sarcoma virus. Activation of p60c-src by middle-T is accompanied both by dephosphorylation of tyrosine 527, a site which negatively regulates src kinase src kinase activity (reviewed in refs 4-6) and by autophosphorylation on tyrosine 416 (refs 7-10). Phosphoprotein p60c-src is subject to cell cycle-specific regulation. It is most active during mitosis and repressed in interphase. Here we report that mitotic p60c-src is dephosphorylated at tyrosine 527. We also show that in cells expressing middle-T, src kinase activity is high both in mitosis and during interphase. An oncogenic mutant src protein, p60c-src(527F), where tyrosine 527 is substituted by phenylalanine, is also highly active in all phases of the cell cycle. 相似文献
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MYKYTOWYCZ R 《Nature》1959,183(4660):555-556
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