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1.
The existence of a circadian variation in the adrenocortical concentrations of cyclic AMP and cyclic GMP in male adult Wistar rats examined 10 days after hypophysectomy is demonstrated. The results suggest that the circadian variations of adrenocortical cyclic nucleotides observed previously in intact rats might not entirely depend upon pituitary corticotrophin. 相似文献
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J. Guillemant S. Guillemant A. Reinberg 《Cellular and molecular life sciences : CMLS》1980,36(3):367-368
Summary The existence of a circadian variation in the adrenocortical concentrations of cyclic AMP and cyclic GMP in male adult Wistar rats examined 10 days after hypophysectomy is demonstrated. The results suggest that the circadian variations of adrenocortical cyclic nucleotides observed previously in intact rats might not entirely depend upon pituitary corticotrophin.Acknowledgment. Thanks are due to Prof. J. M. Racadot and Dr Y. Drouet for their assistance with the histological examinations. 相似文献
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Résués Les effets de l'uranium sur l'excrétion de la glycoprotéine urinaire principale du rat out été étudiés chez 10 animaux. La principale glycoprotéine urinaire augmente de 50% dans les 24 h qui suivent l'administration de l'uranium.
From the Department of Pediatrcs, College of Physicians and Surgeons of Columbia University. 相似文献
From the Department of Pediatrcs, College of Physicians and Surgeons of Columbia University. 相似文献
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E. A. De Felice 《Cellular and molecular life sciences : CMLS》1957,13(9):373-374
Résumé La réserpine administrée par voie intraveineuse chez le chien à dose de 1,5 mg/kg de poids du corps disparaît rapidement du sang artériel. Les quantités de réserpine retrouvées sont de 1,5 µg/ml au bout de 90 s. Il n'y a pas de corrélation entre les quantités de réserpine contenues dans le sang et le début ou la durée de la sédation produite. Au bout de 48 h, moins de 2% de la dose injectée est retrouvée dans l'urine. Etant donné la rapidité avec laquelle la drogue disparaît dans du sang, on ne s'explique pas l'hypersensibilité du chien à son égard. L'excrétion rénale négligeable de la drogue chez le chien ne permet pas d'espérer que des études de clairance rénale éclaircissent le mécanisme d'action de la réserpine chez cet animal.
Agrant for this study and the reserpine (serpasil ®) used in these experiments, were generously given by CIBA Pharmaceutical Products, Inc., Summit, New Jersey. 相似文献
Agrant for this study and the reserpine (serpasil ®) used in these experiments, were generously given by CIBA Pharmaceutical Products, Inc., Summit, New Jersey. 相似文献
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Zusammenfassung Nach peroraler Verabreichung von IAA wird eine vermehrte Ausscheidung von 5-HIAA festgestellt. Eine Hydroxylierung der aufgenommenen IAA wird vermutet. Damit wird ein neuer Weg der Entstehung der 5-HIAA beim Menschen aufgezeigt. 相似文献
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Zusammenfassung Ein hochaktiver, gerinnungsfördernder Faktor wird normalerweise im menschlichen Urin ausgeschieden. Die Ausscheidung ist quantitativ bei gesunden Erwachsenen altersabhängig und bei Urämie wesentlich vermindert. 相似文献
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R. G. G. Andersson H. J. Arnqvist L. Lundholm 《Cellular and molecular life sciences : CMLS》1976,32(5):601-602
Summary The incorporation of leucice-14C into protein in bovine mesenteric arteries was augmented by cyclic GMP (10–3
M) and decreased by cyclic AMP (10–3
M). There was no effect of 5 AMP (10–3
M). The phosphodiesterase inhibiting drugs theophylline (10–3
M) and papaverine (5×10–5 g/ml) both decreased the leucine-14C incorporation.We are indebted to Mrs.Lena Burlin for hear assistance. Finacial support has been provided by the Swedish State Medical Research Council (No. 04X-101X-4498). 相似文献
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Dynamics of excretion of urinary chemosignals in the house mouse (Mus musculus) during the natural estrous cycle 总被引:1,自引:0,他引:1
The volatile fraction of urinary metabolites was investigated chromatographically at five different stages of the natural estrous cycle. A very substantial endocrine dependency has been noted for 11 compounds: 4 ketones, 2 acetate esters, 3 dihydrofuran isomers, dehydro-exo-brevicomin, and 2,5-dimethylpyrazine. The compounds were structurally verified through combined gas chromatography/mass spectrometry. 相似文献
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F. Andreolini B. Jemiolo M. Novotny 《Cellular and molecular life sciences : CMLS》1987,43(9):998-1002
Summary The volatile fraction of urinary metabolites was investigated chromatographically at five different stages of the natural estrous cycle. A very substantial endocrine dependency has been noted for 11 compounds: 4 ketones, 2 acetate esters, 3 dihydrofuran isomers, dehydro-exo-brevicomin, and 2,5-dimethylpyrazine. The compounds were structurally verified through combined gas chromatography/mass spectrometry. 相似文献
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Immunodiffusion technique, with rabbits antibodies against rat glomerular basement membrane (GBM), permits to evidence the presence of GBM antigens into normal urines of 3 rodents (rat, mouse, and guinea-pig). These results confirm the earlier works in human and rabbit urines and show the antigenic communauty existing between the 3 rodents GBM, since we can evidence antigens of 3 different mammals with the same antibody. The origin and the nature of this patterns and the signification of this presence into mammalian urines are discussed. 相似文献
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The incorporation of leucine-14C into protein in bovine mesenteric arteries was augmented by cyclic GMP (10-3 M) and decreased by cyclic AMP (10-3 M). There was no effect of 5'AMP (10-3 M). The phosphodiesterase inhibiting drugs theophylline (10-3 M) and papaverine (5 x 10-5 g/ml) both decreased the leucine-14C incorporation. 相似文献
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Since rare cases of sex chromosome anomalies such as XXX and XXY were observed in the offspring of our XO breeder mice, we performed a cytogenetic analysis of metaphase II oocytes of XO mice to determine whether any changes in chromosomal configurations occur. We found a significantly increased incidence of unpartnered single chromatids in metaphase II oocytes of XO mice. Such single chromatids may contribute to embryonic aneuploidy. In addition, the tendency of the X-chromosome to segregate non-randomly to the oocyte rather than to the polar body was confirmed. 相似文献
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Zusammenfassung Ein salinischer Extrakt desCorpus pineale erzeugt bei normalen, nicht aber bei adrenalektomierten Ratten eine starke Retention von Natrium. Auf Grund der besonderen anatomischen Verhältnisse des Corpus pineale der Ratte vertreten wir die Auffassung, dass die wirksame Substanz, wahrscheinlich Adrenoglomerulotropin, in der Zirbeldrüse selbst erzeugt wird und nicht aus der Nachbarschaft dort angereichert wird. 相似文献
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B. Carletti E. Kehyayan F. Fraschini 《Cellular and molecular life sciences : CMLS》1964,20(7):383-383
Riassunto Si è dosato il contenuto gonadotropinico di urine di soggetti di sesso femminile, tra gli 11 ed i 14 anni di età raccolte in due anni successivi (1961–1962) a mezza primavera ed a mezzo autunno.Si è osservato che il contenuto gonadotropinico era sia nell'una sia nell'altra serie di determinazioni molte volte maggiore (circa dieci volte) nel periodo primaverile in confronto che nel periodo autunnale. 相似文献
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M. Kastelan N. Di Ferrante H. S. Lipscomb 《Cellular and molecular life sciences : CMLS》1970,26(9):937-939
Zusammenfassung Während 2 simulierten, 14 Tage dauernden Raumflügen wurde bei 2 Astronauten untersucht, ob zwischen der Ausscheidung von Glycosaminglycanen und der Ausscheidung der Nebennierenrindensteroide eine Korrelation besteht. Eine signifikante Korrelation zwischen diesen beiden Parametern wurde gefunden. 相似文献