共查询到20条相似文献,搜索用时 15 毫秒
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J. S. C. Fong 《Cellular and molecular life sciences : CMLS》1976,32(5):639-641
Summary Alpha-tocopherol inhibits human platelet aggregation induced by arachidonate sodium, collagen, epinephrine, adenosine diphosphate or thrombin — arachidonate sodium being the most susceptible. The second phase of the biphasic platelet aggregation induced by epinephrine or adenosine diphosphate is preferentially inhibited.This work was supported by the Medical Research Council of Canada, Quebec Medical Council, and a Fraser Scholarship, McGill University. I thank Drs.K. N. Drummond andS. O'Regan for their comments. 相似文献
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Piroxicam inhibited aggregation of human and dog platelets caused by collagen, but not by adenosine diphosphate (ADP). Release of platelet ADP was inhibited by piroxicam. 相似文献
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A. Gibelli C. Montanari D. Bellani V. Mandelli G. Sacchetti 《Cellular and molecular life sciences : CMLS》1973,29(2):186-187
Riassunto L'effeto inibente di farmaci -bloccanti sull'aggregazione di piastrine umane indotta in vitro mediante ADP è risultato proporzionale alle dosi dei farmaci impiegati. La seguente scala gerarchica di potenza è disposta in ordine decrescente di attività: pindolol, K 4423, propranolol, INPEA. 相似文献
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P. P. Gazzaniga G. Di Macco R. La Mancusa A. Oddi G. Pappalardo F. M. Pulcinelli D. Reggio 《Cellular and molecular life sciences : CMLS》1988,44(10):892-894
Summary Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets. 相似文献
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P P Gazzaniga G Di Macco R La Mancusa A Oddi G Pappalardo F M Pulcinelli D Reggio 《Experientia》1988,44(10):892-894
Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets. 相似文献
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Summary Piroxicam inhibited aggregation of human and dog platelets caused by collagen, but not by adenosine diphosphate (ADP). Release of platelet ADP was inhibited by piroxicam. 相似文献
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R. M. Heinicke Linda van der Wal M. Yokoyama 《Cellular and molecular life sciences : CMLS》1972,28(10):844-845
Zusammenfassung Die orale Verabreichung von Bromelain in Form von 2 Ananase®-100-Tabletten an freiwillige Versuchspersonen verminderte bei diesen die Empfänglichkeit für die durch ADP induzierte Aggregation der Blutplättchen.
This work was supported by the Honolulu Chamber of Commerce research grants. 相似文献
This work was supported by the Honolulu Chamber of Commerce research grants. 相似文献
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Effect of manganese on the ADP-induced platelet aggregation 总被引:1,自引:0,他引:1
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The effect of dipyridamole on platelet phospholipids has been studied. After the platelet incubation with dipyridamole, a 38% reduction in the concentration of the sphingomyelin and a 21% increase in phosphatidyl choline were produced. 相似文献
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Zusammenfassung Vier betarezeptorenblockierende Substanzen wurden auf ihre Fähigkeit untersucht, die Adenosindiphosphat-induzierte Thrombozytenaggregation in vitro zu hemmen. Dabei erwies sich die Dosis-Wirkungs-Relation bei LB-46 (Sandoz) am günstigsten, indem diese Substanz eine etwa fünfmal stärkere Aktivität als Propranolol aufweist. Ba-39 089 ist gegenüber Propranolol etwa zweimal weniger wirksam. Für I.C.I. 50 172 konnte bei gleicher Dosierung wie Propranolol überhaupt keine Hemmung festgestellt werden. 相似文献
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The effect of the ADP infusion on the basal platelet count was studied in controls and in rats submitted to the exclusion of the following circulatory districts: splenic, renal, cerebral and of a hind-limb. After these exclusions the ADP-induced thrombocytopenia was less marked than the controls. 相似文献