The prevention of experimentally induced reticulo-sarcoma by hypothyroidism

Zusammenfassung Die Entstehung von Reticulosarkom bei Ratten nach mehrmaliger Injektion von Trypanblau kann unterdrückt werden durch Entkräftung, Verabreichung anti-thyreoidaler Mittel und durch alle andern Faktoren, welche den Stoffwechsel herabsetzen.     

Demonstration of testosterone secretion by testicular tissue of hypophysectomized boar as affected by HCG in organ culture]

Boar Leydig cells undergo a strong atrophy from 1 to 3 months after hypophysectomy but can be reactivated by the gonadotropin HCG in organ culture conditions. This reactivation which appeared at histological and ultrastructural level was evidenced by the capacity of testicular tissue to synthesize testosterone as judged by radioimmunoassay. Both synthesis in the tissue and release into the medium increased according the incubation time with HCG; the adjonction of 17 alpha-OH-pregneolone to culture medium led to increase the intra and extra-tissular concentration of testosterone.     

Splenic thymidine kinase and DNA during early postnatal development of the androgenized female rat

Administration of a pharmacologic dose of testosterone propionate to neonatal female rats had no effect on either thymidine kinase activity or DNA synthesis in the spleen during the first 3 postnatal weeks.     

Immunological reactivity during pregnancy in the mouse

Riassunto Le reazioni allergiche da contatto indotte dal cloridrato di picrile e le risposte anticorpali agli eritrociti di montone sono state quantitativamente valutate in topi femmine nel corso della gravidanza. Mentre le reazioni allergiche sono diminuite nelle femmine gravide rispetto alle vergini, le risposte anticorpali risultano significativamente aumentate. Tali dati fanno supporre l'esistenza nel corso della gravidanza di un controllo ormonale delle risposte immunitarie che potrebbe influenzare positivamente le reazioni meterno-fetali.     

Behaviour ofDrosophila melanogaster is affected by drugs

Summary Reserpine, colchicine and Rb⁺ ions exerted specific effects on sexual behaviour and locomotor activity of the fruit fly. Neuroleptics and antidepressants were inactive.     

Glutamine synthetase,an enzyme characteristic of vertebrate systems in invertebrate tissues

Zusammenfassung Nachweis eines Invertebraten-Enzyms, das bei Vertebraten insbesondere im Nervengewebe eine wichtige Rolle spielt. Diese Glutamin-Synthetase wurde vor allem im optischen Ganglion in der Retina und im Gehirn zweier Tintenfischarten gefunden und überdies in sehr geringer Menge bei Crustaceen und Echinodermen.

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We wish to acknowledge the support of NSF Grant No. GE-19211 to J.E.M. during this study.     

Cholesterol synthesis and related enzymes in rat liver during pregnancy

Summary During pregnancy the synthesis of cholesterol and the activity of 3-hydroxy 3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase fell markedly before parturition; HMGCoA synthase activity was low during pregnancy and fell again immediately before delivery while acetoacetyl-CoA-thiolase was always low and constant.     

Half-life of dehydroepiandrosterone sulfate (DHAS) during pregnancy]

During pregnancy the half-life of DHAS was measured after non tritiated DHAS infusion. At 30 weeks, the mean value obtained for DHAS half-life was 3.64 h +/- 0.74 and it was 3.67h +/- 0.38 at 38 weeks. The half-life of DHAS is shorter in pregnant than in non-pregnant women. Among 14 pathological pregnancies that we studied, 13 cases exhibited a DHAS half-life significantly longer than the average value obtained in normal pregnancies. In retarded fetal growth, the half-life of DHAS was more closely related to fetal than to placental weight.     

Interruption of pregnancy by 5-azacytidine

Zusammenfassung Bei Mäusen unterbricht 5-Azacytidin die Schwangerschaft, und ist maximal wirksam zwischen 4.–6. Graviditätstag.