Effects of N-ethyl maleimide on urea facilitated transport across toad gall bladder

Summary An SH reactive agent, N-ethyl maleimide (10^–3 M for 2 min in the luminal fluid) selectively inhibits the urea transpithelial flux across the toad gall bladder. Thiourea and antipyrine flux is not inhibited. The inhibitory effect on urea flux seems to be exerted on the carrier mechanism of urea transport.     

Effects of Pre- and simultaneous treatment with urea on the induction of chromatid aberrations inVicia faba

Summary Pre- and simultaneous treatments ofVicia faba root tip meristems with urea and ethyl alcohol, mitomycin C, maleic hydrazide,³H-thymidine and X-rays, respectively, were found to result in mutagen-specific changes of the spectrum and yield of induced chromatid aberrations.     

Effects of some components ofCannabis sativa on the regenerating planarian wormDugesia tigrina

Résumé Une méthode simple d'analyse biologique des effects toxiques des substances de la série des cannainoïdes est présentée. Avec cette méthode, il est montré que les tetrahydrocannabinols 1 et 6 ainsi que le cannabidiol agissent sur le métabolisme de la sérotonine.     

Effects of some GABAergic agents on quinine-induced seizures in mice

The effects of some GABAergic agents on seizures induced by quinine were studied in mice. Muscimol, AOAA, DABA and baclofen significantly protected mice against quinine-induced convulsions. Bicuculline effectively enhanced quinine-induced convulsions, and significantly attenuated the protective effects of muscimol, AOAA and DABA against convulsions induced by quinine. Diazepam and phenobarbitone significantly protected mice against convulsions induced by quinine. However, phenytoin did not affect quinine-induced seizures to any significant degree. These results indicate that the convulsant effect of quinine may be due to a disturbance in the status of the GABAergic system.     

Effects of some membrane-active and other compounds on thrombin-induced platelet aggregation

Zusammenfassung Substanzen, welche die thrombin-induzierte Plättchenaggregation hemmen, lassen sich in drei Hauptgruppen aufteilen: 1. membranstabilisierende Steroide, 2. Substanzen, welche die elektrischen Eigenschaften der Membran oder die Permeabilität oder beide beeinflussen, und 3. Substanzen, die eine Erhöhung des intrazellulären cAMP-Spiegels bewirken sollen. Eine Hypothese über die Hemmung der Plättchenaggregation durch Thrombin wird vorgeschlagen.

---

---

Supported in part by Grants No. HE-01648 and No. HE-06350 from the National Heart and Lung Institute. Dr.Mason is a Markle Scholar in Academic Medicine and an N.I.H. Career Development Awardee.     

Effects of some GABAergic agents on quinine-induced seizures in mice.

The effects of some GABAergic agents on seizures induced by quinine were studied in mice. Muscimol, AOAA, DABA and baclofen significantly protected mice against quinine-induced convulsions. Bicuculline effectively enhanced quinine-induced convulsions, and significantly attenuated the protective effects of muscimol, AOAA and DABA against convulsions induced by quinine. Diazepam and phenobarbitone significantly protected mice against convulsions induced by quinine. However, phenytoin did not affect quinine-induced seizures to any significant degree. These results indicate that the convulsant effect of quinine may be due to a disturbance in the status of the GABAergic system.     

Effects of D-penicillamine on some oxidative enzymes of rat organs in vivo

Summary In the liver of neonate rats and in tissues of adult rats a study was made of the effect of D-penicillamine treatment in vivo on the enzymes of peroxide metabolism, lipid peroxidation and other components. It was found that D-penicillamine primarily acts by decreasing lipid peroxidation, thus stabilizing the membrane.Properties of enzymes. Serial publication Part XVI.Acknowledgment. We should like to take the opportunity to express our thanks to the Directorate of Knoll AG, Ludwigshafen. FRG, for the kind gift of Metalcaptase^®.     

Effects of tranylcypromine on the concentrations of some trace amines in the diencephalon and hippocampus of the rat

Summary Concentrations of 4 trace amines in diencephalon and hippocampus of the rat were measured by integrated-ioncurrent mass spectrometry after administration of the antidepressant drug, tranylcypromine. Much larger increases were observed for 2-phenylethylamine and tryptamine than for m- and p-tyramine.Financial support has been provided by the Medical Research Council of Canada, the Psychiatric Services Branch, Province of Saskatchewan, the Alberta Mental health Research Fund, and the Special Services and Research Committee, University of Alberta Hospital.Acknowledgments. The authors wish to thank Dr B.A. Davis for synthesizing the deuterated internal standards and Dr D.A. Durden for supervising the mass spectral analyses. Expert technical assistance was provided by Mr R.C. Mag-Atas and Ms D.G. Calverley. The advice and encouragement of Professors W. G. Dewhurst and A. A. Boulton are gratefully acknowledged.