共查询到20条相似文献,搜索用时 31 毫秒
1.
R. J. Schwartzman K. Kogure R. Busto 《Cellular and molecular life sciences : CMLS》1978,34(9):1175-1177
Summary An i.v. bolus of (14C) deoxyglucose was injected into 4 groups of rats which simultaneously were embolized through the internal carotid artery. 15 and 30 min post embolization there was a massive decrease in (14C) deoxyglucose uptake in both deep and cortical structures. At 4 h a small zone of increased (14C) deoxyglucose uptake persisted around each embolized microsphere. 相似文献
2.
G. Sauermann 《Cellular and molecular life sciences : CMLS》1967,23(10):803-805
Summary The effect of the glycolytic inhibitor 2-deoxy-D-glucose on the oxidation of14C-labelled substrates of the tricarboxylic acid cycle was investigated in ascites carcinoma cells of the mouse. In the presence of high concentrations of glucose, deoxyglucose stimulates the oxidation of pyruvate C-2 and C-3 to CO2, but not the oxidation of succinate C-1,4 to CO2. While deoxyglucose causes, in the absence of glucose, an inhibition of the oxidation of exogenous palmitate C-1 to CO2, it causes, in the presence of glucose, a stimulation of the palmitate oxidation. There is a possible correlation between the effect of deoxyglucose on the intracellular ATP metabolism and the effect of deoxyglucose on the palmitate oxidation. 相似文献
3.
J Trojan J Uriel 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,289(15):1157-1160
The morphological localisation of alphafetoprotein (AFP), serumalbumin (SA), transferrin and immunoglobulins (IgG) has been studied in the developing central nervous system of the Rat by immunocytochemical methods. Evidence is presented of a highly selective staining for AFP and SA, both proteins exhibiting the same topographical distribution. Practically all the areas of the brain and the spinal cord are stained at a given moment of the developmental process. The labeling is cytoplasmic and in the neuronal elements extends to their axonic and dendritic prolongations. The localization of AFP and SA in the nervous system may be related to the well known binding properties of these proteins for varied substances (estrogen and/or fatty acids). The morphological data presented here suggest that both proteins may be actively involved in the uptake of such substances by the cellular structures of the nervous tissue. 相似文献
4.
Neuroactive steroids: State of the art and new perspectives 总被引:1,自引:0,他引:1
Melcangi RC Garcia-Segura LM Mensah-Nyagan AG 《Cellular and molecular life sciences : CMLS》2008,65(5):777-797
Neuroactive steroids include synthetic steroidal compounds and endogenous steroids, produced by endocrine glands (hormonal
steroids) or the nervous tissue (neurosteroids), which regulate neural functions. These steroids bind to nuclear receptors
or act through the activation of membrane-associated signaling pathways to modulate various important processes including
the development of the nervous system, neural plasticity and the adaptive responses of neurons and glial cells under pathological
conditions. Reviewed and updated in the present paper are the pleiotropic and protective abilities of neuroactive steroids.
The fundamental evidence and knowledge gained constitute a profound background that offers interesting possibilities for developing
effective strategies against several disorders of the nervous system.
Received 3 September 2007; received after revision 24 October 2007; accepted 29 October 2007 相似文献
5.
6.
J Cardot 《Experientia》1978,34(10):1261-1263
The tyrosine is decarboxylated in vitro by the central nervous tissue and by the intracardiac nervous tissue of Helix pomatia by aromatic amino-acid decarboxylase. The tyramine obtained is then partially transformed into octopamine by tyramine-beta-hydroxylase. The inhibition of monoamine oxidase favours apparition of the 2 amines. The monoamine oxidase seems able to regulate their synthese and to assure their inactivation. 相似文献
7.
8.
Enanga B Burchmore RJ Stewart ML Barrett MP 《Cellular and molecular life sciences : CMLS》2002,59(5):845-858
Recent progress in understanding the neuro-pathological mechanisms of sleeping sickness reveals a complex relationship between
the trypanosome parasite that causes this disease and the host nervous system. The pathology of late-stage sleeping sickness,
in which the central nervous system is involved, is complicated and is associated with disturbances in the circadian rhythm
of sleep. The blood-brain barrier, which separates circulating blood from the central nervous system, regulates the flow of
materials to and from the brain. During the course of disease, the integrity of the blood-brain barrier is compromised. Dysfunction
of the nervous system may be exacerbated by factors of trypanosomal origin or by host responses to parasites. Microscopic
examination of cerebrospinal fluid remains the best way to confirm late-stage sleeping sickness, but this necessitates a risky
lumbar puncture. Most drugs, including many trypanocides, do not cross the blood-brain barrier efficiently. Improved diagnostic
and therapeutic approaches are thus urgently required. The latter might benefit from approaches which manipulate the blood-brain
barrier to enhance permeability or to limit drug efflux. This review summarizes our current understanding of the neurological
aspects of sleeping sickness, and envisages new research into blood-brain barrier models that are necessary to understand
the interactions between trypanosomes and drugs active against them within the host nervous system.
Received 10 October 2001; received after revision 29 November 2001; accepted 5 December 2001 相似文献
9.
Davoli C Marconi A Serafino A Iannoni C Marcheggiano A Ravagnan G 《Cellular and molecular life sciences : CMLS》2002,59(3):527-539
Nerve growth factor (NGF) belongs by sequence homology to the neurotrophins, a family of proteins binding the same p75 receptor
and closely related members of the Trk family of receptor tyrosine kinases. Fundamental in the vertebrate nervous system,
neurotrophin signals have also been suggested as essential for relatively complex nervous systems occurring in invertebrate
species that live longer than Caenorhabditis elegans and Drosophila melanogaster. Mammalian neurotrophins have been found to influence invertebrate neuronal growth. However, there are only a few data on
the presence of molecules related to neurotrophin signalling components in invertebrates. Our studies provide evidence that
analogues of neurotrophins and neurotrophin receptors are expressed in Eisenia foetida earthworms. In particular, NGF-like and Trk-like immunoreactive proteins are both expressed in the nervous system, whereas
p75-like positivity identifies tubular structures associated with dorsal pores that are involved in the earthworm response
to mechanical irritation or stress.
Received 12 November 2001; received after revision 8 January 2002; accepted 8 January 2002 相似文献
10.
Identification of the bioactive peptide PEC-60 in brain 总被引:1,自引:0,他引:1
Norberg A Gruber S Angelucci F Renlund S Wadensten H Efendic S Ostenson CG Jörnvall H Sillard R Mathé AA 《Cellular and molecular life sciences : CMLS》2003,60(2):378-381
PEC-60 is a 60-residue peptide originally isolated from pig intestine. It inhibits glucose-induced insulin secretion from
perfused pancreas in a hormonal manner and also has biological activity in the immune system. PEC-60-like immunoreactive material
has been reported in catecholamine neurons of the central and peripheral nervous systems, but the peptide has not been identified
from that material. We have now isolated PEC-60 from pig and rat brains with a method that combines column purification procedures
with the specificity of a radioimmunoassay and the sensitivity of mass spectrometry to directly identify the peptide. The
results show that PEC-60, like many other peptides, is expressed in the gastrointestinal tract and the central nervous system.
The specific regional brain distribution and interaction with classical neurotransmitters raise the possibility that PEC-60may
play a role in the central nervous system disorders involving dopamine dysregulation.
Received 6 December 2002; received after revision 10 December 2002; accepted 11 December 2002
RID="*"
ID="*"Corresponding author. 相似文献
11.
C Paulin Y Charnay P M Dubois J A Chayvialle 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1980,291(2):257-260
Substance P (SP) immunoreactive structures were localized by immunofluorescence technique within the central nervous system of human fetuses (12, 15, 19 and 24 weeks old). Specificity of the anti-SP serum was established by immunocytology and radio-immunology. A wide distribution of SP positive structures (pericaryons and/or fibres) was found in brain, spinal cord and dorsal root ganglia. Mesencephalon, pons and dorsal horns of the spinal cord showed very intense fluorescence. The preliminary observations are the first report concerning SP ontogeny in the Human central nervous system. However, it was difficult to ascribe a significance to this neuropeptide during fetal life. 相似文献
12.
J. Janiszewski 《Cellular and molecular life sciences : CMLS》1985,41(9):1199-1200
Summary Internal head heating restricted the flight activity in the cockroachPeriplaneta americana. Heating the metathoracic ganglion did not have any pronounced effect on the flight. It is concluded that in the cockroach the head nervous centers are very heat-susceptible and might be the coordinating center for temperature responses. 相似文献
13.
Delphine Meffre Julien Grenier Sophie Bernard Françoise Courtin Todor Dudev Ghjuvan’Ghjacumu Shackleford Mehrnaz Jafarian-Tehrani Charbel Massaad 《Cellular and molecular life sciences : CMLS》2014,71(7):1123-1148
Wnt signaling is required for neurogenesis, the fate of neural progenitors, the formation of neuronal circuits during development, neuron positioning and polarization, axon and dendrite development and finally for synaptogenesis. This signaling pathway is also implicated in the generation and differentiation of glial cells. In this review, we describe the mechanisms of action of Wnt signaling pathways and their implication in the development and correct functioning of the nervous system. We also illustrate how a dysregulated Wnt pathway could lead to psychiatric, neurodegenerative and demyelinating pathologies. Lithium, used for the treatment of bipolar disease, inhibits GSK3β, a central enzyme of the Wnt/β-catenin pathway. Thus, lithium could, to some extent, mimic Wnt pathway. We highlight the possible dialogue between lithium therapy and modulation of Wnt pathway in the treatment of the diseases of the nervous system. 相似文献
14.
J Nguyen-Legros P Cesaro B Berger M Gay 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(17):1295-1298
The retrograde axonal transport of an iron-dextran complex was observed in neurons of the substantia nigra and of the intralaminar nuclei of the thalamus, after previous injection into the striatum. The histochemical demonstration of iron is simple and rapid, and can be combined with that of horseradish peroxidase, under precise conditions in the sequence of reactions. The iron-dextran complex revealed to be a valuable material for neuronal connectivity studies in the central nervous system. 相似文献
15.
Getting there and being there in the cerebral cortex 总被引:1,自引:0,他引:1
M. Götz 《Cellular and molecular life sciences : CMLS》1995,51(4):301-316
The mammalian neocortex is composed of functional areas that are specified to process particular aspects of information. How is this specification achieved during development? Since cells migrate to their final positions in the developing nervous system, a central issue is the relation between cellular migration and positional information. This review combines evidence for early positional specification in the developing cortex with evidence for cellular dispersion during migration. A model is suggested whereby stable cues provide positional information and minorities of ‘displaced’ cells are respecified accordingly. Comparison with other parts of the CNS reveals that cellular dispersal is ubiquitous and has to be included in any mechanism relaying positional specification. Ontogenetic and phylogenetic considerations suggest that radial glial cells might provide the positional information in the developing nervous system. 相似文献
16.
N Dhainaut-Courtois 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,284(11):941-944
High specific and nonspecific cholinesterase activities have been demonstrated in the whole nervous system of Nereis. These might reveal the existence of a cholinergic nervous system whose control would be exerted in different sites (central nervous centers, muscular junctions...). 相似文献
17.
Summary Transmission electron microscopy was used to study the role of gliosomes in the postembryonic development of the central nervous system in Tubifex (Oligochaetes). 相似文献
18.
Mice injected with tetanus toxin (TTx) showed an increase of 5-hydroxytryptamine (serotonin, 5-HT) levels in the central nervous system. The increment was not uniform throughout the central nervous system. Particularly significant were the 25% and 80% increases observed, respectively, in whole brain and spinal cord. The levels of dopamine and norepinephrine remained unchanged. The subsequent studies of 5-HT turnover revealed a synthesis rate in the tetanic animals that was almost double that of controls. The degradation rate of the amine as well as the levels of 5-hydroxyindolacetic acid were unaffected. 相似文献
19.
J. Aguilera J. Heredero F. Gonzalez Sastre 《Cellular and molecular life sciences : CMLS》1987,43(4):410-412
Summary Mice injected with tetanus toxin (TTx) showed an increase of 5-hydroxytryptamine (serotonin, 5-HT) levels in the central nervous system. The increment was not uniform thoughout the central nervous system. Particularly significant were the 25% and 80% increases observed, respectively, in whole brain and spinal cord. The levels of dopamine and norepinephrine remained unchanged. The subsequent studies of 5-HT turnover revealed a synthesis rate in the tetanic animals that was almost double that of controls. The degradation rate of the amine as well as the levels of 5-hydroxyindolacetic acid were unaffected. 相似文献
20.
A. R. Ameen 《Cellular and molecular life sciences : CMLS》1996,52(3):189-211
The problem of integration and control of the various processes of the metazoan organism is a major challenge to the physiologist. The traditional research strategy in dealing with the problem is neuron-oriented and its roots extend back into the last century when knowledge of hormones was lacking. In the present article, the traditional strategy is analyzed in the light of available data and its logical basis is questioned. Different levels of communication are supposed to occur in the animal or human body. Circulating hormones are responsible for the highest level of communication that occurs between organs or tissues. The central concept in the article is that regulation of circulating hormones constitutes a higher level of control relative to regulation of intercellular hormones. This is regardless of whether the latter occurs in the nervous system or elsewhere. The approach is utilized in defining the mechanism that integrates and controls the part processes of the body. The mechanism is defined as endothelial; the vascular endothelial system is the controlling part and the nervous system is one of the subordinate parts. Thanks to the new approach, meaningful biological explanations of major psychiatric disorders are now possible. 相似文献