Alpha adrenergic control of growth hormone in adult male rats

Summary Intravenous injection of 0.1 mg/kg clonidine into rats under urethane anaesthesia induced a prompt and long-lasting release of growth hormone, estimated by radioimmunoassay (IRGH), which could be abolished by 0.2 mg/kg phentolamine given into the 3rd ventricle. Injection of 3 g/kg clonidine into the 3rd ventricle stimulated also the release of IRGH significantly. Intravenous administration of 0.32 mg/kg phenylephrine caused a small and transient release of IRGH only. These results provide evidence that central -adrenergic stimulation resulting in an increased GH secretion is one importantmechanism in the regulation of this hormone in the rat.     

Effect of some monoamine oxidase inhibitors on deamination of biogenic monoamines by rat liver mitochondrial monoamine oxidase

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Über die Ausscheidung von 3β-Hydroxy-17-Ketosteroiden im Harn von Meerschweinchen

Summary 11-hydroxy-epiandrosterone was isolated and identified from urine of normal untreated female guinea pigs. After cold and hot acid hydrolysis of the urine, we found another 3-hydroxy-17-oxosteroid. Its character was investigated by several methods and we suppose this steroid is9(11)-epiandrosterone, an artificial product of 11-hydroxy-epiandrosterone.     

Ethanol influence on insulin secretion from isolated rat islets

This study was done to delineate the role of alpha- and beta-adrenergic receptors and cyclic AMP in the mechanism of ethanol effects on insulin release from isolated islets. Rats were given an alpha-adrenergic blocker, phentolamine, or a beta-adrenergic blocker, propranolol. In addition, ethanol 1 g/kg was given intragastrically 1 h prior to sacrifice. Glucose mediated insulin release from isolated islets was enhanced by phentolamine and decreased by propranolol. Ethanol treatment inhibited glucose-induced insulin release from isolated islets of control rats as well as those given phentolamine and/or propranolol. Insulin release from isolated islets in response to dibutyryl-cyclic AMP was attenuated by ethanol. Theophylline enhanced glucose mediated insulin release from control islets but ethanol treatment produced a significant inhibition of insulin response. The data suggest that the site of action of the deleterious effects of ethanol on insulin release from isolated islets in rat does not involve adrenergic system and cyclic AMP.     

Effects of pregnancy on the glucose-induced insulin release from cultivated pancreatic islets of the rat

Summary 7-day-cultured islets from pregnant Wistar rats released at 5.6 mM glucose significantly more insulin than islets from nonpregnant rats, whereas in vivo this heigthened glucose sensitivity is lost 48 h post partum.Investigations carried out as a part of the Forschungsprojekt Diabetes mellitus und Fettstoffwechselstörungen supported by the Ministry of Health of German Democratic Republic.     

The peculiarities of capacitance vessel reflex responses

Conclusion Changes of the vessel capacity resulted from the pressor synocarotid reflexes, intestinal chemoreflexes and reflexes from the right atrium or ventricle and electric stimulation of the somatic nerve afferents can be either similarly or differently directed as compared with the responses of the resistance vessels.

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Artificial lung ventilation during diaphragmatic paralysis

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Protein biosynthesis and hyperpolarization of cells

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Topochemical approach to the structure-activity relation. Retroenantio-Gly5,10-gramicidin S

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Normalization by nucleotides of impairments in deamination of nitrogenous compounds in liver of tumor-bearing mice

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Magnug reflexex of the chest musculature in man

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Separation of rat liver mitochondrial amine oxidases

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Interaction of polyene antibiotics and serum lipoproteins

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The effect of chloramphenicol analogs on protein biosynthesis in a cell-freeEscherichia coli B system

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Laboratory of Biological Investigations.

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Laboratory for Chemistry of Antibiotics.     

The tonically acting pulmonary receptors innervated by C fibres

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Mutual replaceability of amide and ester groups in biologically active peptides and depsipeptides

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Inhibition of sodium transport in frog skin by cardiac glycosides of different molecular structure

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Study of neurosecretory cells ofHelix pomatia by intracellular dye injection

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Isoforms of baker's yeast transketolase

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A study of the mechanism of polymyxin M inactivation

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