Effect of ecdysone on glutamic decarboxylase in rat brain

Résumé Nous avons étudié l'effet que produisait l'ecdysone, une hormone de la mue chez les insectes, sur l'activité de l'acide glutamique decarboxylase du cerveau de rat. Nous avons observé que l'activité de cet enzyme augmentait de façon significative chez les rats traités par cette hormone.     

Effect of prolonged hypokinesia on thiamine phosphoric esters content in rat myocardium

Summary Under the effect of prolonged immobilization, the content of thiaminemono-, thiaminedi- and thiaminetriphosphate in rat myocardium decreases.     

The effects of intracerebrally injected oxythiamine on free thiamine and thiamine phosphates content of rat brain

Riassunto L'iniezione intracerebrale di 0,6 moli di OTh nel ratto causa duraturi sintomi di ipereccitabilità e, dopo 24 ore, una modesta diminuzione del contenuto cérébrale di Th fosforilata. L'iniezione di 0,15 moli causa soltanto una molto lieve diminuzione del contenuto che compare al quarto giorno dall'iniezione.     

Changes in acetylcholine content of rat brain by toxic doses of di-isopropyl phosphorofluoridate

Zusammenfassung Die Behandlung mit Phosphorsäure-Di-Isopropylester-Fluorid ergibt im Rattengehirn eine 100 prozentige Erhöhung des totalen ACh-Gehaltes. Der ACh-Anstieg in den Synaptosomen war nur gering.     

Effect of 5-hydroxydopamine on uptake and content of serotonin in rat striatum

Zusammenfassung 5-OH-Dopa und 5-OH-Dopamin senken in vivo den Serotoningehalt und vermindern in vitro dosisabhängig die Aufnahme von³H-Serotonin im Striatum von Ratten. Es kann daher angenommen werden, dass 5-OH-Dopamin in vivo überwiegend eine Verdrängung von Serotonin aus den serotoninergen Speichern verursacht, während in vitro zusätzlich eine Verdrängung von unspezifisch in katecholaminerge Speicher aufgenommenem Serotonin auftreten kann.     

Effect of prostaglandin E1 on rat gastric motility and cyclic nucleotide content

Summary Administration of exogenous prostaglandin E₁ resulted in an increase in contractility of rat fundic muscle measured in vivo; a significant decrease in fundic tissue levels of cyclic-adenosine monophosphate and a significant increase in cyclic-guanosine monophosphate.     

Effect of des-Tyr1-gamma-endorphin on serotonin metabolism in rat brain regions

Intracerebroventricular (i.c.v.) administration of des-Tyr1-gamma-endorphin (0.1 and 1.0 microgram) caused a decrease of the serotonin (5-HT) concentration of the hippocampus. The concentration of 5-HIAA and the pargyline-induced alterations in 5-HT and 5-HIAA were not affected. No effects were noticed in other brain regions.     

Effect of methyl amphetamine on the brain 5-hydroxytryptamine content of isolated and aggregated rats

Zusammenfassung Amphetamin bewirkt eine Vermehrung von 5-Hydroxytryptamin im Gehirn von aggregierten Ratten, während Chlorpromazin diesen Effekt hemmt.     

Effect of methylcobalamin on protein content in liver and serum of partially hepatectomized rat

Zusammenfassung Die Zunahme der Leber- und Serumeiweissmenge bei chronischer Leberstörung von Ratten mit partiel extirpierter Leber wird nach Applikation von Methylcobalamin gefördert. Eine Methylcobalamin induzierte Förderung der Eiweißsynthese in der Leber wird angenommen.     

Effect of prostaglandin E1 on rat gastric motility and cyclic nucleotide content.

Administration of exogenous prostaglandin E1 resulted in an increase in contractility of rat fundic muscle measured in vivo; a significant decrease in fundic tissue levels of cyclic- adenosine monophosphate and a significant increase in cyclic-guanosine monophosphate.     

Effect of centrally active drugs on dopamine oxidation by rat brain catecholamine oxidase

Summary Centrally active drugs of the phenothiazine-, butyrophenone- and iminodibenzyl class markedly decreased the rate of dopamine oxidation in the presence of rat brain catecholamine oxidase.The financial support from Gotfred Lie and Marie Lie's Fond is gratefully acknowledged.     

Effect of diabetes on the enzymes of the cholinergic system of the rat brain

Summary Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities were determined in several brain regions of normal and streptozotocin-induced diabetic rats. The diabetic rats exhibited significant increase in ChAT activity (p<0.05) in all brain regions studied except for the cortex and the midbrain. Meanwhile, the diabetes condition was associated with significant increase (p<0.05) in AChE activity of the bulbus olfactorius, medulla oblongata and cerebellum. These data suggest that uncontrolled diabetes is associated with significant alterations in the brain cholinergic systems.To whom requests of reprints should be addressed.This work was supported by grants from the National Aeronautics and Space Administration (NSG 2183 and NAG-2-411), a grant from the National Institutes of Health (NIH Grant RR0811) and a grant from the Division of Research Resources, National Institutes of Health (NIH Grant RR03020).     

Effect of diabetes on the enzymes of the cholinergic system of the rat brain

Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities were determined in several brain regions of normal and streptozotocin-induced diabetic rats. The diabetic rats exhibited significant increase in ChAT activity (p less than 0.05) in all brain regions studied except for the cortex and the midbrain. Meanwhile, the diabetes condition was associated with significant increase (p less than 0.05) in AChE activity of the bulbus olfactorius, medulla oblongata and cerebellum. These data suggest that uncontrolled diabetes is associated with significant alterations in the brain cholinergic systems.