Responses of isolated blood vessels to acetylcholine,epinephrine, norepinephrine,and histamine

Zusammenfassung Acetylcholin verursachte in den Coronar-, Femoral- und Mesenterialarterien, Catecholamine in den Femoral- und Mesenterialgefässen Konstriktionen, in den Coronargefässen hingegen Dilatation.

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This work was completed in the Department of Physiology, University of Mississippi Medical Center, Jackson (Mississippi USA).     

Occurrence of inhibitory histamine H2-receptors in isolated pulmonary blood vessels of dogs and rats

Summary Isolated, helically cut strips of pulmonary arteries and veins of dogs, and pulmonary arteries of rats, precontracted with norepinephrine or 5-HT exhibited potent concentration-dependent relaxations to impromidine and dimaprit (histamine H₂-agonists). The occurrence of inhibitory histamine H₂-receptors in the pulmonary vasculature could play a modulatory role in hypoxic pulmonary vasoconstriction.Supported by research grants NHLBI-18002, NHLBI-18015 and DA-02339 from the USPHS. We are grateful to Dr D.D.A. Owen of Smith, Kline & French Ltd, England for the generous supply of dimaprit and impromidine. Requests for reprints should be addressed to B.M. Altura.     

Adaptation of the guinea-pig to histamine. sensitivity of the guinea-pig's ileum to histamine and acetylcholine

Résumé L'adaptation des cobayes à l'histamine par voie intrapéritonéale diminue la sensibilité de leur jéjunum isolé à l'histamine. En même temps le jéjunum isolé de cobayes adaptés réagit à l'acétylcholine sans changer remarquablement de susceptibilité. L'activité de l'histaminase dans le jéjunum adapté ne démontre pas la différence en relation avec celle du jéjunum non adapté.

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The study was supported by the Polish Academy of Sciences.     

Effects of temperature on the responses to noradrenaline, isoprenaline and histamine on isolated rabbit mesenteric artery.

On the rabbit mesenteric artery, the elevation of temperature from 25 degrees up to 42 degrees diminished the affinity of histamine, whereas that of noradrenaline to the alpha-adrenoceptors remained unchanged. The presence of beta-adrenoceptors could not be demonstrated.     

Effect of lidoflazine on norepinephrine,angiotensin and serotonin responses in isolated smooth muscle preparations

Résumé Les effets de la lidoflazine ont été étudiés sur les bandelettes aortiques isolées du lapin et les bandelettes gastriques isolées du rat. La lidoflazine antagonise significativement la sérotonine sur ces 2 préparations sans altérer leurs réponses à l'angiotensine et à la noradrénaline.     

Formation of norepinephrine from tyrosine in isolated rabbit heart

Zusammenfassung Die Bildung des Noradrenalins aus Tyrosin konnte im isolierten Kaninchenherzen nachgewiesen werden. Die Reaktion scheint für Tyrosin spezifisch zu sein. Aus Tyramin wurde kein Noradrenalin gebildet. Ebenfalls wurde die Umwandlung von Tyramin in Norsynephrin und von Dopamin in Noradrenalin nachgewiesen.     

Iproniazid interaction with the H3 norepinephrine uptake and retention,on isolated left atrium of guinea-pig

Resumen La incorporación de H³NE a la auricula aislada de cobayo reserpinizado, tratado con Iproniazida (IPN) y atmosfera de Nitrogeno, es superior a la de sus controles sin IPN. En auriculas no reserpinizadas, la IPN aparece como agente bloquenate de la incorporación. Se sugiere que este bloqueo ocurre a nivel de las vesiculas especificas de almacenamiento presentes en las terminaciones nerviosas adrenergicas.     

Responses of the resistance and capacitance vessels reflexly induced from the cardiac chambers

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Influence of sodium on the ability of tyramine to release norepinephrine in isolated guinea-pig left atrium

Resumen El contenido de catecolaminas de la auricula de cobayos tratada con Iproniazida e incubada con nor-epinefrina disminuye significativamente cuando se suspenden en un medio deficiente en sodio (25 mM). En estas condiciones el efecto liberador de norepinephrine inducido por tiramina desaparece.

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This investigation was supported by a research grant from the Instituto Nacional de Prevision, Seguridad Social, Madrid (Spain).     

Free amino acid patterns and other chemical constituents of rabbits' blood and blood vessels

Zusammenfassung Die Verteilung der freien Aminosäuren, von Protein, Fett und Cholesterin im Blut und in verschiedenen Gefässen normaler und hypercholesteremischer Kaninchen wurde untersucht. Geschädigte Aortaabschnitte erhielten mehr Protein, Fett und Cholesterin, aber weniger freie Aminosäuren als normale.

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Supported by grant H-2534 (C-3) from the National Heart Institute, N.I.H., and by a grant from the Eli Lilly Co.