共查询到20条相似文献,搜索用时 31 毫秒
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A. L.-F. Mui 《Cellular and molecular life sciences : CMLS》1999,55(12):1547-1558
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Physiological significance of STAT proteins: investigations through gene disruption in vivo 总被引:7,自引:0,他引:7
D. E. Levy 《Cellular and molecular life sciences : CMLS》1999,55(12):1559-1567
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Negative regulators of cytokine signal transduction 总被引:20,自引:0,他引:20
D. J. Hilton 《Cellular and molecular life sciences : CMLS》1999,55(12):1568-1577
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Interferons as a paradigm for cytokine signal transduction 总被引:6,自引:0,他引:6
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The suppressors of cytokine signalling (SOCS) 总被引:10,自引:0,他引:10
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JAKs and STATs in invertebrate model organisms 总被引:5,自引:0,他引:5
C. R. Dearolf 《Cellular and molecular life sciences : CMLS》1999,55(12):1578-1584
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PPARs: transcriptional effectors of fatty acids and their derivatives 总被引:19,自引:0,他引:19
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Suraiya A. Ansari Randall H. Morse 《Cellular and molecular life sciences : CMLS》2013,70(15):2743-2756
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Agnieszka Siejka Andrew V. Schally Nektarios Barabutis 《Cellular and molecular life sciences : CMLS》2010,67(6):959-964
Growth hormone-releasing hormone (GHRH) can act as a potent growth factor in various cancers. The mitogenic activity of this
neuropeptide is exerted through binding to the pituitary type receptors (GHRH-R) or their splice variants (SV). In the present
work, we studied whether this hormone can activate the JAK2/STAT3 pathway which plays a crucial role in cancer cell proliferation
and is also linked to carcinogenesis. We transfected HeLa human cervical cancer cells, which are not sensitive to GHRH analogs
with the pGHRH-R. Transfected cells responded to the GHRH or its antagonist with an increase or a decrease in proliferation,
respectively. These results were confirmed by the expression of proliferating cell nuclear antigen. We then showed that these
effects are linked to the activation of the JAK2/STAT3 pathway. Our work demonstrates the activation of JAK/STAT3 pathway
by GHRH and sheds further light to the mechanisms of the antitumorogenic action of GHRH antagonists. 相似文献