Role of bile in intestinal absorption of203Pb in rats

Summary The author studied absorption of²⁰³Pb after administering intraduodenally²⁰³Pb eliminated with bile. The results obtained were compared with absorption of203Pb administered into the duodenum as²⁰³PbCl₂ in rats forming 2 groups, one with bile ducts cannulated, the other intact. It was found that bile played an important role in absorption of Pb from the gastrointestinal tract. Absorption of Pb²⁰³ is significantly reduced if the bile is drained off by means of a canula.     

Drug interactions in intestinal absorption of 3H-digitoxin in rats.

The absorption of 3H-digitoxin from perfused rat small intestine was inhibited by probenecid (1.0 x 10-2 M), ethacrynic acid (0.5 x 10-3 M), and mersalyl (8.0 x 10-3 M) indicating that digitoxin absorption is at least partly an active process.     

Drug interactions in intestinal absorption of3H-digitoxin in rats

Summary The absorption of³H-digitoxin from perfused rat small intestine was inhibited by probenecid (1.0×10^–2 M), ethacrynic acid (0.5×10^–3 M), and mersalyl (8.0×10^–3 M) indicating that digitoxin absorption is at least partly an active process.     

Changes in intestinal absorption of glucose in rats treated with ethanol

Riassunto Gli Autori hanno indagato se l'intossicazione subacuta da etanolo provoca nel ratto alterazioni dell'assorbimento intestinale del glucosio. L'assorbimento intestinale del glucosio è diminuito in maniera statisticamente significativa nei ratti trattati per 2 e 7 giorni ed è risultato quasi normale in quelli trattati per 20 giorni con etanolo.     

Effect of sulphates on the intestinal absorption of Sr-85 in rats

Zusammenfassung Unter diversen Sulfaten zeigte die Kombination Barium-Natriumsulfat bei frühzeitiger Applikation stärkste Reduktion des Radiostrontiumgehalts im Skelett (über 90%).     

Small intestinal absorption ofd-galactose and water in fasted and alloxan diabetic rats

Zusammenfassung Leerdarm- und Krummdarm-Aufsaugung vond-Galaktose und Wasser wurde mit einer Pumpendurchströmung in vivo bei normalen und Alloxan-diabetischen Ratten geprüft. 24 Stunden Fasten erhöhte die Aufnahmefähigkeit normaler Ratten, ergab aber keinen Unterschied zwischen normalen Ratten beim Fasten und solchen, die mit Alloxan für 24, 48 und 72 Stunden diabetisch wurden.

---

---

Thanks an due toStanley Smith andPhillip Gray for skilled technical assistance.     

Effect of phosphates,carbonates, and magnesium oxide upon the intestinal absorption of Sr-85 in rats

Zusammenfassung Unter diversen Phosphaten, Karbonaten und Magnesium-Oxyd zeigte die Kombination Trikalzium-Dinatriumphosphat im Skelett die stärkste Reduktion des Radiostrontinumgehalts (fast 90%).     

Interaction between sugars and amino acids in intestinal absorption by rat, in vivo.

The inhibitory action of L-leucine on the intestinal absorption of D-glucose and D-galactose, as well as the inhibitory action of D-galactose on the absorption of L-leucine at various concentrations by rat small intestine has been studied. The further effect was more clearly evidenced when the medium was perfunded through the intestine in a closed circuit system using a peristaltic pump.     

In vivo intestinal absorption of sugars and electrolytes

Riassunto Nell'intestino tenue di ratto in vivo è stato osservato che la concentrazione intracellulare di glucosio o di 3-O-metilglucosio, durante l'assorbimento di questi zuccheri, è sempre minore che nel siero. Ciò lascia presumere che esista una pompa per l'estrusione degli zuccheri a livello della membrana serosale delle cellule assorbenti intestinali.

---

---

This work was supported by a research grant of the Consiglio Nazionale delle Ricerche (CNR), Rome.     

Hepatic proline after bile duct ligation in rats

Since biliary hyperplasia of fascioliasis correlated with hepatic proline level, we examined the occurrence of a similar chemical stimulus during bile obstruction. Uptake of tritiated proline and glycine rose in both hepatocytes and a bile duct enriched cell fraction, following duct ligation in rats. The increased hepatic content of proline but not glycine suggests that proline has a role in post-obstructive biliary proliferation.     

Phosphorylation of thiamine in the intestinal wall during absorption in vivo

Riassunto 2 h dopo l'introduzione di tiamina cloridrato o di tiaminpropildisolfuro nell'intestino tenue di ratto in vivo si trova un aumento significativo di tiamina fosforilata nella parete intestinale, essenzialmente a carico del tiamindifosfato.