共查询到20条相似文献,搜索用时 31 毫秒
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Long-range chromatin regulatory interactions in vivo 总被引:19,自引:0,他引:19
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DNA methylation profiling of human chromosomes 6, 20 and 22 总被引:24,自引:0,他引:24
Eckhardt F Lewin J Cortese R Rakyan VK Attwood J Burger M Burton J Cox TV Davies R Down TA Haefliger C Horton R Howe K Jackson DK Kunde J Koenig C Liddle J Niblett D Otto T Pettett R Seemann S Thompson C West T Rogers J Olek A Berlin K Beck S 《Nature genetics》2006,38(12):1378-1385
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Carninci P Sandelin A Lenhard B Katayama S Shimokawa K Ponjavic J Semple CA Taylor MS Engström PG Frith MC Forrest AR Alkema WB Tan SL Plessy C Kodzius R Ravasi T Kasukawa T Fukuda S Kanamori-Katayama M Kitazume Y Kawaji H Kai C Nakamura M Konno H Nakano K Mottagui-Tabar S Arner P Chesi A Gustincich S Persichetti F Suzuki H Grimmond SM Wells CA Orlando V Wahlestedt C Liu ET Harbers M Kawai J Bajic VB Hume DA Hayashizaki Y 《Nature genetics》2006,38(6):626-635
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DNA methylation represses transcription in vivo. 总被引:9,自引:0,他引:9
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Human-mouse genome comparisons to locate regulatory sites 总被引:21,自引:0,他引:21
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Regulatory element detection using correlation with expression 总被引:25,自引:0,他引:25
We present here a new computational method for discovering cis-regulatory elements that circumvents the need to cluster genes based on their expression profiles. Based on a model in which upstream motifs contribute additively to the log-expression level of a gene, this method requires a single genome-wide set of expression ratios and the upstream sequence for each gene, and outputs statistically significant motifs. Analysis of publicly available expression data for Saccharomyces cerevisiae reveals several new putative regulatory elements, some of which plausibly control the early, transient induction of genes during sporulation. Known motifs generally have high statistical significance. 相似文献
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The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors 总被引:1,自引:0,他引:1
Pancreas development begins with the formation of buds at specific sites in the embryonic foregut endoderm. We used recombination-based lineage tracing in vivo to show that Ptf1a (also known as PTF1-p48) is expressed at these early stages in the progenitors of pancreatic ducts, exocrine and endocrine cells, rather than being an exocrine-specific gene as previously described. Moreover, inactivation of Ptf1a switches the character of pancreatic progenitors such that their progeny proliferate in and adopt the normal fates of duodenal epithelium, including its stem-cell compartment. Consistent with the proposal that Ptf1a supports the specification of precursors of all three pancreatic cell types, transgene-based expression of Pdx1, a gene essential to pancreas formation, from Ptf1a cis-regulatory sequences restores pancreas tissue to Pdx1-null mice that otherwise lack mature exocrine and endocrine cells because of an early arrest in organogenesis. These experiments provide evidence that Ptf1a expression is specifically connected to the acquisition of pancreatic fate by undifferentiated foregut endoderm. 相似文献
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Revealing modular organization in the yeast transcriptional network 总被引:21,自引:0,他引:21
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