| 苦绳中木脂素类化学成分的分离与结构鉴定 |
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| 引用本文： | 贾少华,吕芳,戴荣继,孟薇薇,陈艳,邓玉林. 苦绳中木脂素类化学成分的分离与结构鉴定[J]. 北京理工大学学报, 2015, 35(3): 326-330. DOI: 10.15918/j.tbit1001-0645.2015.03.021 |
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| 作者姓名： | 贾少华 吕芳 戴荣继 孟薇薇 陈艳 邓玉林 |
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| 作者单位： | 北京理工大学生命学院,北京,100081;北京理工亘元医药技术开发中心有限公司,北京,100080 |
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| 基金项目： | 国家重大科学仪器设备开发专项基金资助项目(2012YQ040140) |
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| 摘 要： | 为明确苦绳Dregea sinensis Hemsl中的主要化学成分,采用AB-8大孔吸附树脂、硅胶、Sephadex LH-20葡聚糖凝胶和反相制备液相等色谱方法从苦绳中首次分离得到5个木脂素类化合物. 通过一维和二维核磁共振波谱、有机质谱等方法确定它们分别为4',4"-二羟基-3,3',3",5,5',5"-六甲氧基-7,9':7',9-二环氧-4,8"-氧-8,8'-倍半新木脂素-7",9"-二醇(1),4',4"-二羟基-3,3',3",5,5'-五甲氧基-7,9':7',9-二环氧-4,8"-氧-8,8'-倍半新木脂素-7",9"-二醇(2),(+)-异落叶松树脂醇(3),赤式-愈创木酚基甘油基-β-O-4'-松柏醇(4),diasyringaresinol (5).
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| 关 键 词： | 苦绳 萝藦科 木脂素 化学成分 结构鉴定 |
| 收稿时间： | 2014-09-17 |
Isolation and Structural Identification of Lignans from Dregea sinensis Hemsl |
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| JIA Shao-hu,L,#; Fang,DAI Rong-ji,MENG Wei-wei,CHEN Yan and DENG Yu-lin. Isolation and Structural Identification of Lignans from Dregea sinensis Hemsl[J]. Journal of Beijing Institute of Technology(Natural Science Edition), 2015, 35(3): 326-330. DOI: 10.15918/j.tbit1001-0645.2015.03.021 |
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| Authors: | JIA Shao-hu,L&# Fang,DAI Rong-ji,MENG Wei-wei,CHEN Yan DENG Yu-lin |
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| Affiliation: | 1.School of Life Science, Beijing Institute of Technology, Beijing 100081, China2.Beijing BIT&GY Pharmaceutical R&D Co.Ltd., Beijing 100081, China |
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| Abstract: | In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4',4"-dihydroxy-3,3',3",5,5',5"-hexamethoxy-7,9':7',9-diepoxy-4,8"-oxy-8,8'-sesquineolignan-7",9"-diol (1), 4',4"-dihydroxy-3,3',3",5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8"-oxy-8,8'-sesquineo-lignan-7",9"-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time. |
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| Keywords: | Dregea sinensis Hemsl Asclepiadaceae Lignans constituent structure identification |
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