| 当归挥发油的提取工艺优化及抗氧化性研究 |
| |
| 引用本文： | 当归挥发油的提取工艺优化及抗氧化性研究. 当归挥发油的提取工艺优化及抗氧化性研究[J]. 山东科学, 2022, 35(6): 16-23. DOI: 10.3976/j.issn.1002-4026.2022.06.003 |
| |
| 作者姓名： | 当归挥发油的提取工艺优化及抗氧化性研究 |
| |
| 作者单位： | 1.鲁南厚普制药有限公司,山东 临沂 2760062.鲁南制药集团股份有限公司 中药制药共性技术国家重点实验室,山东 临沂 2760063.鲁南贝特制药有限公司,山东 临沂 276006 |
| |
| 基金项目： | 山东省重点研发计划(2020CXGC010505);临沂市兰山区科技创新发展计划(2026) |
| |
| 摘 要： | 为了探索当归挥发油的最佳提取工艺及其抗氧化活性,以道地当归药材为试材,采取单因素及响应面分析法,将当归粉碎粒径、加水倍数、提取时间作为考察因素,以挥发油提取率为考察指标,优选挥发油提取工艺条件,并在此工艺条件下提取当归挥发油,利用DPPH自由基清除率测定挥发油抗氧化活性。结果表明最佳工艺参数为粉碎粒径24目、加水倍数6倍、提取时间7 h,此工艺条件当归挥发油提取率高;抗氧化性试验表明当归挥发油质量浓度为1.2 mg/mL时,DPPH自由基清除率最高为51.9%。该试验应用单因素及响应曲面模型优化的工艺稳定,挥发油提取率高,此条件下生产的挥发油具有较好的抗氧化性,为当归挥发油提取工艺参数的明确及优化提供了科学、合理的依据。
|
| 关 键 词： | 当归 挥发油 响应面法 抗氧化性 |
| 收稿时间： | 2021-11-24 |
Optimization of extraction process and antioxidant activity of Angelica sinensis volatile oil |
| |
| GUO Tian-tian,FANG Zhao-ying,LIU Zhen-yuan,ZHANG Wei,BI Yan-yan,SUN Yan,GUAN Yong-xia. Optimization of extraction process and antioxidant activity of Angelica sinensis volatile oil[J]. Shandong Science, 2022, 35(6): 16-23. DOI: 10.3976/j.issn.1002-4026.2022.06.003 |
| |
| Authors: | GUO Tian-tian FANG Zhao-ying LIU Zhen-yuan ZHANG Wei BI Yan-yan SUN Yan GUAN Yong-xia |
| |
| Affiliation: | 1. Lunan Houpu Pharmaceutical Co., Ltd., Linyi 276006, China2. State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine, Lunan Pharmaceutical Group Co., Ltd.Linyi 276006, China3. Lunan Beite Pharmaceutical Co., Ltd., Linyi 276006, China |
| |
| Abstract: | To determine the most optimal extraction process for angelica volatile oil and its antioxidant activity. In this experiment, authentic Angelica sinensis was used as the test material and the single factor and response surface analysis methods were adopted. The particle size of angelica granules, water addition ratio, and extraction time were investigated. In addition, volatile oil yield was evaluated, and the volatile oil extraction process was optimized. Under the conditions of this process, the volatile oil of A. sinensis was extracted, and the antioxidant activity of the volatile oil was determined based on the DPPH free radical scavenging rate. The results showed that the optimum process parameters were particle size of 24 mesh, water addition ratio of 6, and extraction time of 7 h. Under these conditions, the extraction rate of volatile oil from A. sinensis was high.The antioxidant assay showed that when the concentration of A. sinensis volatile oil was 1.2 mg/mL, the DPPH radical scavenging rate was 51.9%. The process optimized by the single factor and response surface model was stable, and the extraction rate of the volatile oil was high. The volatile oil produced under these conditions had good antioxidant activity, which can provide scientific and rational guidance for clarifying and optimizing the process parameters for extracting A. sinensis volatile oil. |
| |
| Keywords: | Angelica sinesis volatile oil response surface methodology antioxidant |
|
| 点击此处可从《山东科学》浏览原始摘要信息 |
|
点击此处可从《山东科学》下载全文 |
|
