| 海马MF-CA3突触习得性LTP诱导后PPF效应的变化 |
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| 引用本文： | 严文文, 刘文晓, 黄俊柅, 肖鹏. 海马MF-CA3突触习得性LTP诱导后PPF效应的变化[J]. 华南师范大学学报（自然科学版）, 2014, 46(4): 1. DOI: 10.6054/j.jscnun.2014.06.114 |
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| 作者姓名： | 严文文 刘文晓 黄俊柅 肖鹏 |
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| 作者单位： | 1.华南师范大学生命科学学院,广州 510631 |
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| 基金项目： | 国家自然科学基金项目(39300039) |
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| 摘 要： | 采用电生理学与行为学结合的方法，通过慢性微电极埋植技术及双脉冲检测技术，观察大鼠海马MF-CA3突触在明暗辨别学习过程中形成习得性长时程增强（Long-term potentiation, LTP）后双脉冲易化（Paired-pulse facilitation, PPF）效应的变化. 结果表明：Mossy fibers-CA3（MF-CA3）突触习得性LTP形成前的PPF易化率为138.36%9.25%，形成后则为114.75%8.42%，差异极显著（p 0.01），而基线对照组在长达7天的检测中，PPF易化率稳定在140%左右. 研究结果显示，MF-CA3突触的习得性LTP的表达可能与突触前递质释放的改变有关.
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| 关 键 词： | 习得性LTP PPF MF-CA3 海马 大鼠 |
| 收稿时间： | 2014-03-28 |
Change of Paired-pulse Facilitation after Behavioral LTP at MF-CA3 Synapses in Hippocampus |
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| Yan Wenwen, Liu Wenxiao, Huang Junni, Xiao Peng. Change of Paired-pulse Facilitation after Behavioral LTP at MF-CA3 Synapses in Hippocampus[J]. Journal of South China Normal University (Natural Science Edition), 2014, 46(4): 1. DOI: 10.6054/j.jscnun.2014.06.114 |
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| Authors: | Yan Wenwen Liu Wenxiao Huang Junni Xiao Peng |
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| Affiliation: | 1.School of Life Science,South China Normal University,Guangzhou 510631,China |
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| Abstract: | The technique of paired-pulse test combined with electrophysiology and behavioral learning was used to examine the effect of behavioral long-term potentiation (LTP) on paired-pulse facilitation (PPF) efficacy at hippocampal MF-CA3 synapses after behavioral learning. The results showed that in baseline (non-training) group, the PPF ratio was stable at the level of 140% or so. However, in training group, the PPF ratio was 138.36%9.25% before learning-dependent LTP and was significantly decreased to 114.75%8.42% after learning-dependent LTP induction (p 0.01). These results suggest that the expression of behavioral LTP at MF-CA3 synapses may be related to presynaptic neurotransmitter release. |
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| Keywords: | behavioral LTP PPF MF-CA3 hippocampus rat |
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