| 重组戊型肝炎疫苗的免疫原性试验 |
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| 引用本文： | 陈献花,楼琦,刘金明,金晓音. 重组戊型肝炎疫苗的免疫原性试验[J]. 实验动物科学, 2003, 20(3): 15-17 |
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| 作者姓名： | 陈献花 楼琦 刘金明 金晓音 |
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| 作者单位： | 浙江省实验动物中心,杭州,310013 |
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| 摘 要： | 目的 研究重组戊型肝炎疫苗的免疫原性。方法 通过对小鼠、新西兰兔的多点皮内注射及肌肉注射 ,然后测定其抗体效价 ,研究重组戊型肝炎疫苗的性能。结果 小鼠在免疫 7d后开始产生抗体 ,两周抗体阳性率为80 % ,四周抗体阳性率达 10 0 %。新西兰兔从第二周后开始产生抗体 ,第三周达到高峰 ,抗血清在 1∶6 4 0 0稀释度的阳性率达 4 0 %。结论 重组戊型肝炎疫苗免疫动物具有良好的免疫原性 ,为进一步研究开发戊肝疫苗对人体的免疫提供了基础
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| 关 键 词： | 戊型肝炎病毒 重组疫苗 免疫原性 |
| 文章编号： | 1006-6179(2003)03-0015-03 |
| 收稿时间： | 2003-09-25 |
| 修稿时间： | 2003-01-28 |
Immunologenic Charaterization of Recombinant Hepatitis E Vaccine |
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| CHEN Xian|hua,LOU Qi,LIU Jin|ming,JIN Xiao|yin. Immunologenic Charaterization of Recombinant Hepatitis E Vaccine[J]. Laboratory Animal Science, 2003, 20(3): 15-17 |
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| Authors: | CHEN Xian|hua LOU Qi LIU Jin|ming JIN Xiao|yin |
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| Abstract: | Objective To study immunologenic characteristics of recombinant hepatitis E vaccine.Methods Mice and rabbits were immunized with recombinant hepatitis E vaccine by multipoint intradermal injections and muscle injections,then the serum antibody titer was measured.Resaults The serum antibody was detected 7 days after mice immunized.The positive rate was 80% after 2 weeks and 100% after 4 weeks. In rabbits,antibody was detected after 2 weeks and reached the peak after 3 weeks,the serum antibody positive rate was 40% on 1∶6400 dilution.Conclusion The results indicated that the recombinant hepatitis E vaccine had good immunogenic and can be used for hepatitis E vaccine research. |
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| Keywords: | Hepatitic E virus Recombinant vaccine Immunological character |
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