| 卷烟诱导小鼠咳嗽和痰液分泌模型的建立 |
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| 引用本文： | 毕波,周昆,郑赛晶,金永明,孟庆乃,胡利民. 卷烟诱导小鼠咳嗽和痰液分泌模型的建立[J]. 实验动物科学, 2010, 27(2): 10-12 |
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| 作者姓名： | 毕波 周昆 郑赛晶 金永明 孟庆乃 胡利民 |
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| 作者单位： | 1. 天津中医药大学中医药研究院,天津市中药药理学重点实验室,天津,300193
2. 上海烟草(集团)公司技术中心,上海,200082 |
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| 摘 要： | 目的为对在卷烟中加入添加剂以达到止咳祛痰目的的研究做出有效评价,建立普通卷烟诱导小鼠咳嗽和痰液分泌的模型。方法小鼠在仅鼻吸烟(nose-only)装置的环境中每天暴露1 h,持续一个月后,利用氨水喷雾引咳法和气管段酚红法对咳嗽潜伏时间、咳嗽次数及气管内分泌物含量进行检测。结果吸烟组小鼠咳嗽潜伏时间显著减少,咳嗽次数增加,气管内分泌物OD值显著增加。结论该卷烟诱导小鼠咳嗽及痰液分泌模型建立成功。
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| 关 键 词： | 卷烟 仅鼻吸烟 咳嗽 痰液分泌 动物模型 |
| 收稿时间： | 2010-04-28 |
Establishment of Cigarette Induced Cough and Sputum Secretion Mice Model |
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| BI Bo,ZHOU Kun,ZHENG Sai-jing,JIN Yong-ming,MENG Qing-nai,HU Li-min. Establishment of Cigarette Induced Cough and Sputum Secretion Mice Model[J]. Laboratory Animal Science, 2010, 27(2): 10-12 |
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| Authors: | BI Bo ZHOU Kun ZHENG Sai-jing JIN Yong-ming MENG Qing-nai HU Li-min |
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| Affiliation: | BI Bo1,ZHOU Kun1,ZHENG Sai-jing2J,IN Yong-ming2,MENG Qing-nai2,HU Li-min1(1.Institute of Traditional Chinese Medicine,Tianjin University of TCM,Tianjin Key Laboratory of Chinese medicine Pharmacology,Tianjin 300193,China)(2.The Technical Center of Shanghai Tobacco(group) Company,Shanghai 200082,China) |
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| Abstract: | Objective To establish a cigarette induced cough and sputum secretion mice model for effective evaluation of the effect of reduce the dangers of cigarettes with additives.Methods Mice were exposed to smoke through the nose-only device for one hour everyday,the cough latency time and cough frequency were tested by ammonia water method and the OD values of sputum secretions was tested by phenol red method.Results The cough time of model group mice significantly decreased,the cough frequency of model group mic... |
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| Keywords: | Cigarette Nose-only Cough Sputum secretion Animal model |
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