| 重结晶微粉化提高布洛芬溶出度 |
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| 引用本文： | 周敏毅,陈建峰,刘晓林. 重结晶微粉化提高布洛芬溶出度[J]. 北京化工大学学报(自然科学版), 2003, 30(4): 6-8 |
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| 作者姓名： | 周敏毅 陈建峰 刘晓林 |
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| 作者单位： | 北京化工大学教育部超重力工程研究中心,北京,100029 |
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| 基金项目： | 国家高技术研究发展计划(863计划);2001AA18061; |
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| 摘 要： | 文中在1L烧瓶实验装置中采用重结晶法以乙醇和丙酮为溶剂，水为沉淀剂进行了布洛芬的微粉化实验。通过优化重结晶过程的参数，例如体积比、温度、浓度、搅拌转速和连续相加料速度，确定了在温度低于5℃，转速高于800r/min，以乙醇为溶剂，按 1∶2的体积比以8mL/min以下的连续相加料速度将0.6～0.8mol/L的布洛芬乙醇溶液加入水可以得到平均粒度小于4μm，收率在92%以上的布洛芬产品。通过扫描电镜、X射线衍射对布洛芬粒度与结晶性进行了对比分析，以及通过溶出度测试比较了重结晶产品与原料药溶出的差异，显示出了重结晶产品在溶出方面的优越性。
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| 关 键 词： | 布洛芬 微粉化 重结晶 溶出度 布洛芬 微粉化 重结晶 溶出度 |
| 修稿时间： | 2002-10-24 |
A recrystallization method for improving ibuprofen dissolution |
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| ZHOU Min-yi CHEN Jian-feng LIU Xiao-lin. A recrystallization method for improving ibuprofen dissolution[J]. Journal of Beijing University of Chemical Technology, 2003, 30(4): 6-8 |
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| Authors: | ZHOU Min-yi CHEN Jian-feng LIU Xiao-lin |
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| Affiliation: | Research Center of the Ministry of Education for High Gravity Engineering and Technology; Beijing University of Chemical Technology; Beijing; China |
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| Abstract: | The recrystallization method is an important method to produce micronized drugs. In an one liter flask device, with ethanol and acetone chosen as solvent candidates and distilled water chosen as precipitator, the main factors which might influence the mean particle size and recovery rate of recrystallized ibuprofen were studied in this article. Experimental results show that the optimum recrystallization conditions are as following: ethanol chosen as solvent, 5℃ or lower temperature, 800r/min or higher stirring speed, and adding 0.6～0.8 mol/ L,ibuprofen ethanol solution to water with a volume ratio less than 1: 2 and solution infusion rate less than 8 mL/min. Under such conditions, a product of 4um mean particle size and over 92% recovery rate was prepared.The recrystallized product and ibuprofen material were characterized by XRD and SFM techniques. Furthermore, a dissolution experiment proved the advantages of the recrystalllized product. |
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| Keywords: | ibuprofen micronization recrystallization dissolution |
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