Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum |
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| Authors: | Email author" target="_blank">Z?RusznákEmail author K?Pocsai I?Kovács á?Pór B?Pál T?Bíró G?Szücs |
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| Institution: | (1) Department of Physiology, Medical and Health Science Centre, University of Debrecen, 4012 Debrecen, Hungary;(2) Department of Pathology, HBM Kenézy Gyula County Infirmary, Bartók Béla u. 2-26, 4043 Debrecen, Hungary |
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| Abstract: | In this work, the distributions of some acid-sensitive two-pore-domain K+ channels (TASK-1, TASK-2 and TASK-3) were investigated in the rat and human cerebellum. Astrocytes situated in rat cerebellar tissue sections were positive for TASK-2 channels. Purkinje cells were strongly stained and granule cells and astrocytes were moderately positive for TASK-3. Astrocytes isolated from the hippocampus, cerebellum and cochlear nucleus expressed TASK channels in a primary tissue culture. Our results suggest that TASK channel expression may be significant in the endoplasmic reticulum of the astrocytes. The human cerebellum showed weak TASK-2 immunolabelling. The pia mater, astrocytes, Purkinje and granule cells demonstrated strong TASK-1 and TASK-3 positivities. The TASK-3 labelling was stronger in general, but it was particularly intense in the Purkinje cells and pia mater.Received 25 February 2004; received after revision 19 April 2004; accepted 28 April 2004 |
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| Keywords: | TASK immunopositivity astrocyte culture cerebellum endoplasmic reticulum human brain |
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