Cadmium-induced changes in renal hemodynamics in the domestic fowl |
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| Authors: | D N Prashad E A Hawkins R Blackburn J Haslam |
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| Institution: | (1) Thames Polytechnic, School of Biological Sciences and Environmental Health, Wellington Street, SE18 6PE London, (England);(2) Chelsea College, University of London, Manresa Road, SW3 6LX London, (England) |
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| Abstract: | Summary Low i.v. doses of cadmium chloride (15  g Cd) given to pullets resulted in a significant reduction in urine flow (UF), glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). However, in hens treated with the heavy metal chelate FeNa EDTA prior to cadmium treatment no oliguria or reduction in GFR or ERPF was observed.It is suggested that the renal changes following the i. v. administration of cadmium to diuretic hens and alleviated in hens primed with the heavy metal chelate may result from changes in glomerular hemodynamics. |
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| Keywords: | Glomerular filtration rate effective renal plasma flow FeNa EDTA chelate |
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