Reduction of high affinity glutamate uptake in rat hippocampus by two polyamine-like toxins isolated from the venom of the predatory waspphilanthus triangulum F |
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Authors: | J van Marle T Piek A Lind J van Weeren-Kramer |
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Institution: | (1) Department of Pharmacology, University of Amsterdam, Academic Medical Centre, Meibergdreef 15, 1105 AZ Amsterdam, (The Netherlands) |
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Abstract: | Summary Two components of the venom of the predatory waspPhilanthus triangulum F. significantly reduce — to a greater or less extent — the high affinity uptake of glutamate in rat hippocampus. A concentration of 10 M -PTX caused a reduction of 74%, while the other component, -PTX, at the same concentration, caused a reduction of 18%. Hence the effect of -PTX on high affinity glutamate uptake in the hippocampus is comparable with its effect on high affinity glutamate uptake in insect neuromuscular junctions. Contrary to our previous findings that -PTX has no effect on high affinity glutamate uptake in insect glutamatergic terminal axons, however, -PTX significantly reduces high affinity glutamate uptake in the hippocampus, albeit less effectively than -PTX. |
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Keywords: | Glutamate high affinity uptake hippocampus insect toxins -PTX" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-PTX -PTX" target="_blank">gif" alt="delta" align="BASELINE" BORDER="0">-PTX polyamines |
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