Role of vasostatin-1 C-terminal region in fibroblast cell adhesion |
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| Authors: | Eleonora Dondossola Anna Gasparri Angela Bachi Renato Longhi Marie-Hélène Metz-Boutigue Bruno Tota Karen B Helle Flavio Curnis Angelo Corti |
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| Institution: | (1) Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, via Olgettina 58, 20132 Milan, Italy;(2) Consiglio Nazionale delle Ricerche, Milan, Italy;(3) INSERM U575, Strasbourg, France;(4) Department of Cell Biology, University of Calabria, Cosenza, Italy;(5) Department of Biomedicine, University of Bergen, Bergen, Norway; |
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| Abstract: | Fibroblast adhesion can be modulated by proteins released by neuroendocrine cells and neurons, such as chromogranin A (CgA)
and its N-terminal fragment vasostatin-1 (VS-1, CgA1–78). We have investigated the mechanisms of the interaction of VS-1 with fibroblasts and of its pro-adhesive activity and have
found that the proadhesive activity of VS-1 relies on its interaction with the fibroblast membrane via a phospholipid-binding
amphipathic α-helix located within residues 47–66, as well as on the interaction of the adjacent C-terminal region 67–78,
which is structurally similar to ezrin–radixin–moesin-binding phosphoprotein 50 (a membrane-cytoskeleton adapter protein),
with other cellular components critical for the regulation of cell cytoskeleton. |
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