Beta-adrenergic-stimulated adenylate cyclase activity in normal and EBV-transformed lymphocytes |
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| Authors: | R P Ebstein M Steinitz J Mintzer I Lipshitz J Stessman |
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| Institution: | (1) Department of Geriatric Research, Jerusalem Mental Health Center-Ezrath Nashim, P. O. B. 140, Jerusalem, Israel;(2) Department of Hematology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel |
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| Abstract: | Summary Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproterenol-stimulated cyclic AMP synthesis was observed in transformed cells, forskolin-stimulated cyclic AMP accumulation was preserved. A parallel loss of125-iodocyanopindolol binding sites suggests that the reduction in beta-adrenergic-stimulated AMP synthesis is due to receptor down regulation. |
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| Keywords: | Epstein-Barr virus beta-adrenergic receptors cyclic AMP synthesis forskolin adenylate cyclase lymphocytes |
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