Stem cells and their niche: a matter of fate |
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| Authors: | O Naveiras G Q Daley |
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| Institution: | (1) Graduate Program of Biological and Biomedical Sciences, and Div. of Hematology/Oncology, Harvard Medical School, Children’s Hospital, Karp Family Research Building, 7th floor, 300 Longwood Avenue Boston, Massachusetts 02115, USA, Boston;(2) Division of Hematology/Oncology, and Department of Biological Chemistry and Molecular Pharmacology, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA |
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| Abstract: | Embryonic stem cells provide an in vitro model for developmental biologists to study cell fate decisions during ontogenesis, while somatic stem cells allow physiologists
to understand tissue homeostasis in the adult. The behavior of stem cells is dependent on an intimate relationship with a
supportive niche. This brief review highlights some of the most important recent trends in stem cell biology, focusing in
particular on the supportive microenvironments for both embryonic and adult stem cells. Known intrinsic and extrinsic molecular
players from the best-characterized stem cell types are summarized, illuminating a number of shared environmental cues among
tissues originating from all three embryonic germ layers.
Received 6 October 2005; received after revision 27 December 2005; accepted 17 January 2006 |
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| Keywords: | Embryonic stem cell somatic stem cell niche asymmetric division self-renewal differentiation regenerative medicine |
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