Mcl-1 is a potential therapeutic target in multiple types of cancer |
| |
Authors: | C Akgul |
| |
Institution: | (1) Faculty of Arts and Sciences, Department of Chemistry, Biochemistry Research Group, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey |
| |
Abstract: | Resistance to apoptosis is a common challenge in human malignancies contributing to both progress of cancer and resistance
to conventional therapeutics. Abnormalities in a variety of cell intrinsic and extrinsic molecular mechanisms cooperatively
promote tumor formation. Therapeutic approaches that specifically target components of these molecular mechanisms are getting
widespread attention. Mcl-1 is a highly expressed pro-survival protein in human malignancies and its cellular expression is
tightly regulated via multiple mechanisms. Mcl-1 differs from other members of the Bcl-2 family in having a very short half-life. So inhibition
of its expression and/or neutralization of its anti-apoptotic function will rapidly make Mcl-1-dependent cells more susceptible
to apoptosis and provide an opportunity to combat several types of cancers. This review summarizes the current knowledge on
the regulation of Mcl-1 expression and discusses the alternative approaches targeting Mcl-1 in human cancer cells whose survivals
mainly depend on Mcl-1.
Received 6 October 2008; received after revision 21 October 2008; accepted 10 November 2008 |
| |
Keywords: | " target="_blank"> Apoptosis cancer Bcl-2 family Mcl-1 therapeutic |
本文献已被 SpringerLink 等数据库收录! |