Preferential excretion of glycated albumin in C57BL-Ks-J mice: Effects of diabetes |
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| Authors: | A Kowluru R A Kowluru |
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| Institution: | (1) Division of Life Sciences, Los Alamos National Laboratory, University of California, 87545 Los Alamos, New Mexico, USA;(2) Present address: Division of Endocrinology, Department of Medicine, University of Wisconsin School of Medicine, H4/568 Clinical Sciences Center, 600 Highland Avenue, 53 792 Madison, Wisconsin, USA |
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| Abstract: | Urinary excretion of glycated albumin was quantitated in genetically hyperglycemic mice (C57BL-Ks-J, db/db mice), a model for non-insulin-dependent diabetes mellitus, and compared with their non-diabetic littermates. The data indicated a preferential excretion of glycated albumin in non-diabetic mice. This phenomenon of  editing of glycated albumin is decreased significantly in diabetic mice. Quantitative measurements of overall excretion of glycated albumin suggested that the loss of editing in diabetic mice is due to the dilution of glycated albumin by the unmodified albumin which is excreted in large amounts in diabetic mice. Therefore, the loss of editing observed in this model resembled the one we characterized in insulin-dependent diabetic humans and a streptozotocin-diabetic rat model3. |
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| Keywords: | C57BL-Ks-J mice db/db mice glycated albumin urinary excretion |
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