Trafficking and stability of voltage-gated calcium channels |
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Authors: | Brett?A?Simms Email author" target="_blank">Gerald?W?ZamponiEmail author |
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Institution: | (1) Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Dr. NW, Calgary, T2N 4N1, Canada; |
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Abstract: | Voltage-gated calcium channels are important mediators of calcium influx into electrically excitable cells. The amount of
calcium entering through this family of channel proteins is not only determined by the functional properties of channels embedded
in the plasma membrane but also by the numbers of channels that are expressed at the cell surface. The trafficking of channels
is controlled by numerous processes, including co-assembly with ancillary calcium channel subunits, ubiquitin ligases, and
interactions with other membrane proteins such as G protein coupled receptors. Here we provide an overview about the current
state of knowledge of calcium channel trafficking to the cell membrane, and of the mechanisms regulating the stability and
internalization of this important ion channel family. |
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Keywords: | |
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