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Deficiency of fibrinolytic enzyme activities in the serum of patients with Alzheimer-type dementia |
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| Authors: | T Aoyagi T Wada F Kojima M Nagai S Harada T Takeuchi K Isse M Ogura M Hamamoto K Tanaka T Nagao |
| Institution: | (1) Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, 141 Tokyo, Japan;(2) Showa College of Pharmaceutical Sciences, 3-chome, Higashitamagawa-gakuen, Machida-shi, 194 Tokyo, Japan;(3) Tokyo Metropolitan Tama Geriatric Hospital, 1-7-1 Aoba-cho, Higashi-Murayama-shi, 187 Tokyo, Japan |
| Abstract: | Previously we reported that there is a kallikrein deficiency in the cerebral tissue of patients with Alzheimer-type dementia. The present study was performed to investigate protease changes in the serum of these patients. The results showed that the kallikrein activity was normal, but that the activities of plasmin and urokinase were significantly low. The present findings indicate a derangement in the clotting and fibrinolytic systems in Alzheimer patients. |
| Keywords: | Alzheimer's disease patients' serum clotting system fibrinolytic system plasmin urokinase thrombin |
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