COX-2与CYPlBl在人乳腺癌中的表达及意义

目的探讨人乳腺癌组织中COX-2和CYPlBl的表达规律及与临床病理特征的关系，对认识其在乳腺癌发生发展中的作用奠定初步病理学基础。方法应用免疫组织化学方法检测42例乳腺癌组织中COX-2和CYPlBl的表达情况，结合临床病理指标进行研究分析。结果在乳腺癌中COX-2和CYPIBl表达阳性率分别为78．6％和73．8％。COX-2的阳性表达与乳腺癌淋巴结转移、组织学分级显著相关（P〈0．05）；CYPlBI的阳性表达与组织学分级、ER表达显著相关（P〈0．05）。乳腺癌COX-2与CYPlBI表达呈正相关（r=0．481，P〈0．01）。结论人乳腺癌组织存在COX-2与CYPlBl的共同阳性表达，COX-2可能促进CYPlBl表达，共同作用参与乳腺癌的发生发展。

Co-expression of Cyclooxygenase-2 and Cytochrome P450 1B1 in Human Breast Cancer and Its Significances

Objectivc To investigate the expression of COX-2 and CYP1 B1 in human breast cancer and the correlation between expression and clinicopathologic characteristic, laying a pathologic foundation for better understanding of their roles in the tumorigenesis of breast cancer cells. Methods Immunohistochemical method was applied to check the expression of COX-2 and CYP1 B1 protein in 42 cases of breast cancer cells. Results Positive expression rates of COX-2 and CYP1B1 were 78.6% and 73.8% respectively. Expression of COX-2 correlated with axillary lymph node metastasis and histologic grade （p 〈 0.05 ） , whereras expression of CYP1 B1 correlated with histologic grade and estrogen receptor（ p 〈 0. 05 ）. There was a significant correlation between expression of COX-2 and CYP1BI in breast cancer（ r = 0. 481 , P 〈 0.01 ）. Conclusion Both COX-2 and CYP1 B1 express and function in human breast tumorigenesis. COX-2 may play a positive role in upregulating CYP1B1.