| 由mdr_1基因引起的MDR表型的逆转 |
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| 引用本文： | 张伟伟,邵淑丽.由mdr_1基因引起的MDR表型的逆转[J].高师理科学刊,2006,26(1):65-67. |
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| 作者姓名： | 张伟伟 邵淑丽 |
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| 作者单位： | 齐齐哈尔大学,生命科学与工程学院,黑龙江,齐齐哈尔,161006 |
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| 摘 要： | 多药耐药(M DR)是肿瘤治疗失败的主要原因,而肿瘤细胞多药耐药基因(m dr1)编码的细胞膜糖蛋白P170的过度表达是最常见的发生机制.论述了M DR表型在蛋白质和基因水平逆转的研究进展情况,蛋白质水平的逆转过程通过寻找合适的P-gp抑制剂来实现.目前正在进行以traiq-u idar为代表的第3代抑制剂的研究,基因水平的逆转根据机理不同,可分为反义RNA、反义寡核苷酸、核酸和RNA i等4种技术,其中RNA干扰技术是目前逆转肿瘤M DR现象的最新技术,它具有高效性、高特异性和快速性等特点,该技术正在为肿瘤的化疗开创新的前景.
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| 关 键 词： | MDR RNAi P-gp |
| 文章编号： | 1007-9831(2006)01-0065-03 |
| 修稿时间： | 2005年11月9日 |
The development of MDR mediated by mdr1 gene and the reversal |
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| ZHANG Wei-wei,SHAO Shu-li.The development of MDR mediated by mdr1 gene and the reversal[J].Journal of Science of Teachers＇College and University,2006,26(1):65-67. |
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| Authors: | ZHANG Wei-wei SHAO Shu-li |
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| Abstract: | Multidrug resistance(MDR) is the main reason of curing tumour-failed,and its common mechanism is cell membrane glycoprotein P_(170) overexpression that is coded by the tumour cell mdr_1.Discusses that investigated progression of reversion of MDR in protein level and gene level.Apposite P-gp inhibitor can achieve reversion in protein level.Now traiquidar is stuied as the third inhibitor.Reversion mechanisms of gene level are different,such as antisense RNA,antisense oligonucleotide,nucleic acid and RNAi,and RNAi is the most new technique that is used in MDR-reversed.This technique has some characteristics,such as high effect,high specificity and tacho,and it starts new outlook of neoplastic cure. |
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| Keywords: | MDR RNAi P-gp |
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