基于图论的分裂型人格障碍多加权脑结构网络研究

基于图论方法分析分裂型人格障碍(SPD)患者与健康对照在脑结构网络局部和全局参数上的差异.根据Brainnetome脑图谱将大脑皮层划分为246个脑区，利用扩散加权图像重建脑白质神经纤维束，构建以神经纤维束条数、密度、长度和优化的密度为加权方式的脑结构网络.计算网络节点参数和全局参数，通过假设检验找出具有显著性差异的脑区.结果发现，SPD患者与健康人的脑结构网络在全局参数上无显著性差异;在节点参数上，6个脑区存在显著性差异;差异脑区在位置上显示出左右脑不对称性，在功能上与认知、情感和感知高度相关.研究结果可为疾病诊断治疗提供重要参考.

Graph Theory Based Study on Multi-weighted Structural Brain Network of Schizotypal Personality Disorder

With graph theory methods， this study identified the differences in nodal and global parameters between schizotypal personality disorder(SPD) and healthy control(HC). Firstly， the whole brain was divided into 246 regions of interest(ROIs)based on the human Brainnetome Atlas， then the fiber bundles were reconstructed based on DWI images， and the structural networks were constructed by statistics under the four weighting methods: fiber number， fiber density， fiber length and optimized fiber density. Secondly， nodal and global parameters were calculated， and brain ROIs with significant differences were determined by two-sample t-tests between groups. The results show that there is no difference in global parameters， but in nodal scale， SPD is significantly different in six ROIs. The distribution of ROIs is asymmetric in the left and right hemisphere. The functions of ROIs are highly related to cognition， emotion and perception. These findings would help the diagnosis and treatment of SPD.