峨嵋双蝴蝶植物提取物的抗五步蛇毒作用

研究峨嵋双蝴蝶植物水提物的抗五步蛇毒作用.建立小鼠五步蛇毒中毒模型,观察小鼠的中毒表现,并统计小鼠的死亡率,比较小鼠组织出血、组织坏死及组织溃疡状况.结果发现,峨嵋双蝴蝶植物水提物给药组动物的死亡率较模型组的明显下降,局部和全身症状较轻,而且随着剂量的增加症状显著减轻,尤其是对于组织的保护作用比较明显.峨嵋双蝴蝶植物水提物具有抗五步蛇毒作用,能降低蛇毒毒性.

Antitoxic Effect of Extracts of Tripterospemum Cordatum Against Deinagkist rodon Acutus Snake Venom

The antitoxic effect of Tripterospemum cordatum aqueous extracts against Deinagkistrodon acutus snake venom is researched.The BACA/C mice were divided into five group according to the dosage of Tripterospemum cordatum aqueous extracts applied:low dosage,middle dosage,high dosage,blank group and model group,each group of health conditions being observed after 7-days intra-gastric administration.For the last time of administration,each group was intraperitoneally injected with Agkistrodon acutus snake venom after one hour later,then the mice’s poisoning performance was observed and the death rate was calculated,and each group of mice’s tissue bleeding,death and ulceration compared.The results showed that the aqueous extract of Tripterospemum cordatum at the low dosage,middle dosage and high dosage all reduced the mortality caused by Agkistrodon acutus snake venom poisoning and relieved some symptoms;with the increase of the dosage the symptoms decreased significantly,and the protection effect on the tissue was especially apparent.It can be concluded that the aqueous extract of Tripterospemum cordatum has antitoxic effect against Agkistrodon acutus snake venom and decrease the toxicity.