75例弥漫性轴索损伤的疗效分析

为改进脑弥漫性轴索损伤(ＤＡＩ)的治疗及其预后措施，笔者将1998年1月至2003年12月收治的脑弥漫性轴索损伤患者75例,分为综合治疗组（35例）和对照组（40例），综合治疗组在常规治疗的基础上,联合应用尼莫通、纳络酮、亚低温、高压氧进行综合治疗.根据GOS预后标准发现，对照组死亡率60%,恢复良好15%.综合治疗组死亡率42.9%,恢复良好25.7%.积极的综合治疗是提高治愈率的关键，能显著降低脑弥漫性轴索损伤(ＤＡＩ)的死亡率.

Therapeutic Outcome and Prognosis Analysis of Diffuse Axonal Injury: A Report of 75 Cases

Objective:To Investigate the therapeutic effects and the prognosis of diffuse axonal injury(DAI).Methods:Seventy-five patients with DAI who were admitted to our department from Jan.1998 to Dec.2003 were divided at random into two groups,the therapeutic group(n=35) and the control group(n=40).The patients in the therapeutic group were suffered to the general therapeutic measures,combined with other measures including Nimodipine,Naloxone,moderate hypothermia and hyperbaric oxygenation.The patients in the control group were treated with the general therapeutic measures only.Results:According to the standards of GOS prognosis,the mortality rate of the patients in the therapeutic group(42.9%) was much lower than that of the patients in the control group(60%),and the recovery rate of the therapeutic group patients(25.7%) was much higher than that of the control group patients(15%).There was significant difference in mortality and recovery rate between the two groups by X2 test(P<0.05).Conclusion:The therapeutic method of multi-measures may play the key role in improving the clinical outcomes for DAI,and it can significantly decrease the mortality of the patients with DAI.