铜铁共催化烯烃串联加成/环化合成异喹啉二酮

发展了一种铜/铁协同催化的N-烯丙酰基苯甲酰胺串联加成/环化/偶联合成叔烷基化异喹啉二酮的反应.在廉价金属Cu/Fe协同催化作用下，烷基偶氮试剂介导N-丙烯酰基-N-烷基氯代苯甲酰胺发生串联加成/环化，区域选择性地切断C-Cl键而发生进一步交叉偶联，以41%~78%的产率合成了一系列远端双重α-官能团化叔烷基取代的异喹啉二酮骨架.该反应首次利用卤代苯甲酰胺去芳构化而形成的超共轭自由基为偶联体与偶氮试剂发生交叉偶联，选择性地在碳-卤键位置构建碳（叔）-碳键.此偶联策略将为深入拓展叔烷基-芳基交叉偶联提供新的思路.

Cu/Fe Co-Catalyzed Cascade Addition/Cyclization of Alkenes Toward Isoquinolinediones

A Cu/Fe-cocatalyzed cascade addition/cyclizaion/cross-coupling of N-methacryloyl halobenzamides with azo reagents toward dual tert-alkylating isoquinolinediones was developed.Under the synergistic CuI/Fe catalysis,alkyl azo reagent mediated a cascade addition/cyclization of N-alkyl-N-methacryloyl halobenzamides,followed by further radical cross-coupling via the cleavage of C-Cl bond with site selectivity,leading to a series of dual tert-alkylating isoquinolinediones in 41%~78% yields.The reaction realized the radical cross-coupling of azo reagent with hyper-conjugated free radicals arising from a prior dearomatzation of methacryloyl halobenzamides and constructed the carbon (tertiary) -carbon bond at the position of C-Cl bond,thereby providing a new idea exploring the tertiary alkyl-aryl cross-coupling reactions.